Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Synergistic activation of gingival fibroblasts by oral pathogens and inflammatory tissue environment as a new pathomechanism of chronic inflammation in periodontitis.

2019/35/B/NZ5/01823

Keywords:

periodontitis Porphyromonas gingivalis gingival fibroblast inflammation cytokine

Descriptors:

  • NZ3_001:
  • NZ6_004:
  • NZ5_003:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Aleksander Marek Grabiec 

Number of co-investigators in the project: 5

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 1 741 452 PLN

Project start date (Y-m-d): 2020-11-02

Project end date (Y-m-d): 2024-05-01

Project duration:: 42 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. The Role of Gingival Fibroblasts in the Pathogenesis of Periodontitis
    Authors:
    Aleksandra Wielento, Katarzyna B Lagosz-Cwik, Jan Potempa, Aleksander M Grabiec
    Academic press:
    Journal of Dental Research (rok: 2023, tom: 102(5), strony: 489-496), Wydawca: Sage
    Status:
    Published
    DOI:
    10.1177/00220345231151921 - link to the publication
  2. Accessory fimbrial subunits and PPAD are necessary for TLR2 activation by Porphyromonas gingivalis
    Authors:
    Aleksandra Wielento, Grzegorz P Bereta, Katarzyna Szczęśniak, Anna Jacuła, Marina Terekhova, Maxim N Artyomov, Yoshiaki Hasegawa, Aleksander M Grabiec, Jan Potempa
    Academic press:
    Molecular Oral Microbiology (rok: 2023, tom: 38(4), strony: 334-346), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/omi.12427 - link to the publication
  3. The Role of Gingival Fibroblasts in the Pathogenesis of Periodontitis
    Authors:
    Aleksandra Wielento, Katarzyna B Lagosz-Cwik, Jan Potempa, Aleksander M Grabiec
    Academic press:
    Journal of Dental Research (rok: 2023, tom: 102(5), strony: 489-496), Wydawca: Sage
    Status:
    Published
    DOI:
    10.1177/00220345231151921 - link to the publication
  4. TLR2 Activation by Porphyromonas gingivalis Requires Both PPAD Activity and Fimbriae
    Authors:
    Aleksandra Wielento, Grzegorz P. Bereta, Katarzyna B. Łagosz-Ćwik, Sigrun Eick, Richard J. Lamont, Aleksander M. Grabiec, Jan Potempa
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 823685), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.823685 - link to the publication
  5. Accessory fimbrial subunits and PPAD are necessary for TLR2 activation by Porphyromonas gingivalis
    Authors:
    Aleksandra Wielento, Grzegorz P Bereta, Katarzyna Szczęśniak, Anna Jacuła, Marina Terekhova, Maxim N Artyomov, Yoshiaki Hasegawa, Aleksander M Grabiec, Jan Potempa
    Academic press:
    Molecular Oral Microbiology (rok: 2023, tom: 38(4), strony: 334-346), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/omi.12427 - link to the publication
  6. TLR2 Activation by Porphyromonas gingivalis Requires Both PPAD Activity and Fimbriae
    Authors:
    Aleksandra Wielento, Grzegorz P. Bereta, Katarzyna B. Łagosz-Ćwik, Sigrun Eick, Richard J. Lamont, Aleksander M. Grabiec, Jan Potempa
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 823685), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.823685 - link to the publication

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