Projects funded by the NCN

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Information of the project and the call

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Novel insights into hydrogen sulfide-mediated cytoprotection - can H2S prevent the progression of Duchenne muscular dystrophy?

2019/35/B/NZ3/02817

Keywords:

H2S Duchenne muscular dystrophy iPSC induced pluripotent stem cells cardiomyopathy gene therapy

Descriptors:

  • NZ3_008:
  • NZ3_002:
  • NZ5_003:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Łoboda 

Number of co-investigators in the project: 6

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 1 791 132 PLN

Project start date (Y-m-d): 2020-07-28

Project end date (Y-m-d): 2026-07-27

Project duration:: 72 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (17)
  • Book publications / chapters in book publications (2)
  1. Cardioprotective Effects of Hydrogen Sulfide and Its Potential Therapeutic Implications in the Amelioration of Duchenne Muscular Dystrophy Cardiomyopathy
    Authors:
    Agnieszka Łoboda, Józef Dulak
    Academic press:
    Cells (rok: 2024, tom: 13, strony: 46053), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells13020158 - link to the publication
  2. Molekularne mechanizmy dystrofii mięśniowej Duchenne'a i nowe możliwości terapeutyczne [Molecular mechanisms of Duchenne muscular dystrophy and new therapeutic strategies].
    Authors:
    Paulina Podkalicka, Małgorzata Myszka, Józef Dulak, Agnieszka Łoboda
    Academic press:
    Postępy Biochemii (rok: 2022, tom: 68, strony: 109-122), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2021_428 - link to the publication
  3. Genetic strategies for therapy of Duchenne muscular dystrophy.
    Authors:
    Agnieszka Łoboda, Jeffrey S Chamberlain, Józef Dulak
    Academic press:
    Molecular Therapy Nucleic Acids (rok: 2025, tom: 36, strony: 102759), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.omtn.2025.102759 - link to the publication
  4. Hypoxia as a Driving Force of Pluripotent Stem Cell Reprogramming and Differentiation to Endothelial Cells
    Authors:
    Paulina Podkalicka, Jacek Stępniewski, Olga Mucha, Neli Kachamakova-Trojanowska, Józef Dulak, Agnieszka Łoboda
    Academic press:
    Biomolecules (rok: 2020, tom: 10, strony: 1614), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10121614 - link to the publication
  5. Terapie komórkowe i genetyczne w dystrofii mięśniowej Duchenne'a – możliwości i ograniczenia
    Authors:
    Agnieszka Łoboda, Józef Dulak
    Academic press:
    Standardy Medyczne/Pediatria (rok: 2023, tom: 20, strony: 587-595), Wydawca: Media-Press Sp. z.o.o.
    Status:
    Published
  6. Nuclear Factor Erythroid 2-Related Factor 2 and Its Targets in Skeletal Muscle Repair and Regeneration
    Authors:
    Agnieszka Łoboda, Józef Dulak
    Academic press:
    Antioxid Redox Signaling (rok: 2023, tom: 38, strony: 619-642), Wydawca: Mary Ann Liebert, Inc.
    Status:
    Published
    DOI:
    10.1089/ars.2022.0208 - link to the publication
  7. Hydrogen sulfide as a therapeutic option for the treatment of Duchenne muscular dystrophy and other muscle-related diseases
    Authors:
    Katarzyna Kaziród , Małgorzata Myszka, Józef Dulak, Agnieszka Łoboda
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2022, tom: 79, strony: 20-29), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-022-04636-0 - link to the publication
  8. Proteome Profiling of the Dystrophic mdx Mice Diaphragm.
    Authors:
    Olga Mucha, Małgorzata Myszka, Paulina Podkalicka, Bianka Świderska, Agata Malinowska, Józef Dulak, Agnieszka Łoboda
    Academic press:
    Biomolecules (rok: 2023, tom: 13, strony: 1648), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom13111648 - link to the publication
  9. Sodium hydrosulfide moderately alleviates the hallmark symptoms of Duchenne muscular dystrophy in mdx mice.
    Authors:
    Małgorzata Myszka, Olga Mucha, Paulina Podkalicka, Urszula Waśniowska, Józef Dulak, Agnieszka Łoboda
    Academic press:
    European Journal of Physiology (rok: 2023, tom: 955, strony: 175928-175943), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2023.175928 - link to the publication
  10. Cell therapy for Duchenne muscular dystrophy: promises, challenges, and controversies.
    Authors:
    Agnieszka Łoboda, Józef Dulak
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2025, tom: 82, strony: 356), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00018-025-05904-5 - link to the publication
  11. Dysregulated Autophagy and Mitophagy in a Mouse Model of Duchenne Muscular Dystrophy Remain Unchanged Following Heme Oxygenase-1 Knockout
    Authors:
    Olga Mucha, Katarzyna Kaziród, Paulina Podkalicka, Kinga Rusin, Józef Dulak, Agnieszka Łoboda
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 23, strony: 470), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010470 - link to the publication
  12. Dysregulated iron homeostasis in dystrophin-deficient cardiomyocytes: correction by gene editing and pharmacological treatment.
    Authors:
    Kalina Andrysiak, Gabriela Machaj, Dominik Priesmann, Olga Woźnicka, Alicja Martyniak, Guillem Ylla, Marcus Krüger, Elżbieta Pyza, Anna Potulska-Chromik, Anna Kostera-Pruszczyk, Agnieszka Łoboda, Jacek Stępniewski, Józef Dulak
    Academic press:
    Cardiovascular Research (rok: 2024, tom: 120, strony: 69-81), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/cvr/cvad182 - link to the publication
  13. Cell-free strategies for cardiomyocyte proliferation and heart repair
    Authors:
    Agnieszka Łoboda, Tomasz Zieliński, Józef Dulak
    Academic press:
    Pharmacological Reports (rok: 2026, tom: 78, strony: 65-89), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s43440-025-00805-7 - link to the publication
  14. GYY4137, a slow-releasing hydrogen sulfide donor, attenuates skeletal muscle abnormalities in a murine model of Duchenne muscular dystrophy
    Authors:
    Małgorzata Myszka, Ewa Jakubczak, Olga Mucha, Kalina Hajok, Urszula Waśniowska, Anna Nalepa, Józef Dulak, Agnieszka Łoboda
    Academic press:
    Antioxidants & Redox Signaling (rok: 2025, tom: 43, strony: 115-137), Wydawca: Mary Ann Liebert, Inc.
    Status:
    Published
    DOI:
    10.1089/ars.2024.0702 - link to the publication
  15. Simvastatin does not alleviate muscle pathology in a mouse model of Duchenne muscular dystrophy
    Authors:
    Olga Mucha, Paulina Podkalicka, Katarzyna Kaziród, Emilia Samborowska, Józef Dulak, Agnieszka Łoboda
    Academic press:
    Skeletal Muscle (rok: 2021, tom: 11, strony: 21), Wydawca: BioMed Central Ltd., Springer Nature
    Status:
    Published
    DOI:
    10.1186/s13395-021-00276-3 - link to the publication
  16. Pluripotent Stem Cell-Based Approaches for Heart Repair: Unlocking the Potential of Genetic Modifications
    Authors:
    Józef Dulak*, Tomasz Zieliński, Alicja Józkowicz, Agnieszka Łoboda*
    Academic press:
    Molecular Therapy (rok: 2025, tom: 33, strony: 4766-4783), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.ymthe.2025.07.009 - link to the publication
  17. Molekularne mechanizmy dystrofii mięśniowej Duchenne'a i nowe możliwości terapeutyczne
    Authors:
    Paulina Podkalicka, Małgorzata Myszka, Józef Dulak, Agnieszka Łoboda
    Status:
    Accepted for publication
  1. Comparison of Two Differentiation Protocols of Human-Induced Pluripotent Stem Cells into Cardiomyocytes
    Authors:
    Agnieszka Łoboda, Monika Kłaptocz, Katarzyna Kaziród, Jan Wolnik, Monika Biniecka, Jacek Stępniewski, Józef Dulak
    Book:
    Methods in Molecular Biology (rok: 2024, tom: 2835, strony: 69-82), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/978-1-0716-3995-5_7 - link to the publication
  2. Techniki inżynierii genetycznej w terapii genowej, medycynie regeneracyjnej i transplantacyjnej
    Authors:
    Agnieszka Łoboda, Józef Dulak
    Book:
    Genetyka medyczna i molekularna (rok: 2023, tom: 2, strony: 409-431), Wydawca: Wydawnictwo Naukowe PWN SA
    Status:
    Published
    DOI:
    10.53271/2023.089 - link to the publication

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