Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The 'omics' of renal cancer nucleolus: towards identification of new cancer markers and therapeutic targets.

2019/35/B/NZ5/00695

Keywords:

renal cancer Fuhrman grading ISUP/WHO grading nucleolus ribosome biogenesis transcriptomics snoRNA microRNA proteomics metabolomics

Descriptors:

  • NZ3_001:
  • NZ5_001:
  • NZ2_002:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Centrum Medyczne Kształcenia Podyplomowego, Szkoła Nauk Medycznych

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Piekiełko-Witkowska 

Number of co-investigators in the project: 10

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 2 236 573 PLN

Project start date (Y-m-d): 2020-07-20

Project end date (Y-m-d): 2026-07-19

Project duration:: 72 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (9)
  1. Nucleolar Proteins and Non-Coding RNAs: Roles in Renal Cancer
    Authors:
    Piotr Popławski , Joanna Bogusławska , Karolina Hanusek, Agnieszka Piekiełko-Witkowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45668), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222313126 - link to the publication
  2. The Role of TCOF1 Gene in Health and Disease: Beyond Treacher Collins Syndrome
    Authors:
    Małgorzata Grzanka, Agnieszka Piekiełko-Witkowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45676), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  1. miR-9-5p potentially regulates the expression of genes in nucleoli-enriched fractions of renal cell carcinoma cells
    Authors:
    Dorota Kwapisz, Piotr Popławski, Małgorzata Grzanka, Alex Białas, Joanna Bogusławska, Agnieszka Piekiełko-Witkowska
    Conference:
    Non-coding RNA in medicine (rok: 2023, tom: Non-coding RNA medicine, strony: 78), Wydawca: EMBO
    Data:
    konferencja 15-18 maja 2023
    Status:
    Published
    DOI:
    nie - link to the publication
  2. Proteomics of the nucleoli-enriched fractions reveals alterations in renal cell carcinoma
    Authors:
    A. Piekielko-Witkowska, B. Skupień-Rabian,U. Jankowska, M. Grzanka, B. Rybicka,J. Bogusławska, P. Popławski
    Conference:
    Molecular Oncology 17 (Suppl. 1) (2023) 1–597 (rok: 2023, tom: EACR 2023: Innovative Cancer Science, 12-15 June 2023, Torino, Italy, strony: 60-61), Wydawca: John Wiley & Sons Ltd
    Data:
    konferencja 12-15 czerwca 2023
    Status:
    Published
    DOI:
    10.1002/1878-0261.13471 - link to the publication
  3. AREG regulates expression of nucleolar proteins and stimulates growth of renal cancer
    Authors:
    P. Popławski, G. Hoser, K. Bielak, T. Skirecki, D. Nowis, M. Mączewski, B. Skupień-Rabian, U. Jankowska, A. Piekielko-Witkowska
    Conference:
    FEBS Open Bio 14 (Suppl. 2) (2024) 94–516 (rok: 2024, tom: Mining biochemistry for human health and well-being, 48th FEBS Congress, 29 June–3 July 2024, Milano, Italy, strony: 407), Wydawca: Wiley
    Data:
    konferencja 29.06.2024-03.07.2024
    Status:
    Published
    DOI:
    10.1002/2211-5463.13837 - link to the publication
  4. The quantitative analysis of the morphological parameters of the nucleoli as a new tool for the determination of clear cell renal cell carcinoma malignancy
    Authors:
    Grzanka M, Popławski P, Piekiełko-Witkowska A
    Conference:
    The 7th Warsaw COnference on Perspectives of Molecular Oncology (rok: 2022, tom: The 7th Warsaw COnference on Perspectives of Molecular Oncology, strony: 24-24), Wydawca: Narodowy Instytut Onkologii im. M. Skłodowskiej-Curie, PIB w Warszawie
    Data:
    konferencja 06-07.10.2022
    Status:
    Published
    DOI:
    BEZ - link to the publication
  5. Regulatory role of miR-9-5p disturbed in nucleoli-enriched fractions in protein expression and oncogenic pathways in clear cell renal cell carcinoma
    Authors:
    D. Kwapisz, M. Grzanka, A. Adamiok-Ostrowska, J.Bogusławska, A. Piekiełko-Witkowska
    Conference:
    FEBS Open Bio 14 (Suppl. 2) (2024) 94–516 (rok: 2024, tom: Mining biochemistry for human health and well-being, 48th FEBS Congress, 29 June–3 July 2024, Milano, Italy, strony: 471), Wydawca: Wiley
    Data:
    konferencja 29.06.2024-03.07.2024
    Status:
    Published
    DOI:
    10.1002/2211-5463.13837 - link to the publication
  6. Transcriptomic analysis of nucleoli-enriched RNA fractions reveals disturbed expression of non-coding RNAs in renal cancer
    Authors:
    Piotr Popławski, Małgorzata Grzanka, Joanna Bogusławska, Beata Rybicka, Agnieszka Piekiełko-Witkowska
    Conference:
    EMBO Workshop Ribosome Synthesis (rok: 2022, tom: 12th triennial Conference on Ribosome Synthesis and the 3rd EMBO Conference on Ribosome Synthesis, strony: 106-106), Wydawca: EMBO
    Data:
    konferencja 17-21.08.2022
    Status:
    Published
    DOI:
    bez - link to the publication
  7. BOP1 protein and morphometric parameters of the nucleoli as a new tool for the determination of renal clear cell carcinoma grading
    Authors:
    M. Grzanka, P. Popławski, A. Piekiełko-Witkowska
    Conference:
    FEBS Open Bio 14 (Suppl. 2) (2024) (rok: 2024, tom: Mining biochemistry for human health and well-being, 48th FEBS Congress, 29 June–3 July 2024, Milano, Italy, strony: 303), Wydawca: Wiley
    Data:
    konferencja 29.06.2024-03.07.2024
    Status:
    Published
    DOI:
    10.1002/2211-5463.13837 - link to the publication
  8. LncRNA SNHG4 disturbed in nucleoli-enriched fractions of renal cell carcinoma cells (ccRCC) potentially regulates cancer-associated gene expression
    Authors:
    Joanna Bogusławska, Joanna Życka-Krzesińska, Agnieszka Piekiełko-Witkowska
    Conference:
    Non-coding RNA medicine (rok: 2023, tom: Non-coding RNA medicine, strony: 79), Wydawca: EMBO
    Data:
    konferencja 15-18 maja 2023
    Status:
    Published
    DOI:
    bez - link to the publication
  9. The quantitative analysis of the morphological parameters of the nucleoli as a new tool for the determination of clear cell renal cell carcinoma malignancy
    Authors:
    Grzanka M, Popławski P, Piekiełko-Witkowska A
    Conference:
    The 7th Warsaw COnference on Perspectives of Molecular Oncology (rok: 2022, tom: The 7th Warsaw COnference on Perspectives of Molecular Oncology, strony: 24-24), Wydawca: Narodowy Instytut Onkologii im. M. Skłodowskiej-Curie, PIB w Warszawie
    Data:
    konferencja 06-07.10.2022
    Status:
    Published
    DOI:
    BEZ - link to the publication

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