Testing of cation carrier derivatives as prospective therapeutic agents for the treatment of B-cell-derived malignancies.
2019/35/B/NZ5/01445
Keywords
Descriptors
- NZ5_007: Leczenie chorób człowieka
- NZ6_001: Odporność swoista i nieswoista
Panel
NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution
Warszawski Uniwersytet Medyczny, Wydział Lekarski
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 7
Call
OPUS 18 – announced on 2019-09-16
- Amount awarded
- 2 345 246 PLN
- Project start date
- 2020-07-06
- Project end date
- 2025-10-05
- Project duration
- 63 months (the same as in the proposal)
- Project status
- Project completed
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (1)
-
Potassium/sodium cation carriers robustly up-regulate CD20 antigen by targeting MYC, and synergize with anti-CD20 immunotherapies to eliminate malignant B cells.
- Authors:
- Torun A., Zdanowicz A., Miazek-Zapala N., Zapala P., Pradhan B., Jedrzejczyk M., Ciechanowicz A., Pilch Z., Skorzynski M., Słabicki M., Rymkiewicz G., Barankiewicz J., Martines C., Laurenti L., Struga M., Winiarska M., Golab J., Kucia M., Ratajczak M.Z., Huczynski A., Calado D.P., Efremov D.G., Zerrouqi A., and Pyrzynska B.
- Academic press:
- Haematologica (year: 2024, volume: Haematologica Early view Dec 19, 2024, pages: 46053), Publisher: Ferrata-Storti Foundation
- Status:
- Published
- DOI:
- 10.3324/haematol.2024.285826 – link to the publication
Articles in post-conference publications (3)
-
Salinomycin-induced actin reorganization limits the presence of CD20 antigen on extracellular vesicles and augments the efficacy of lymphoma immunotherapy.
- Authors:
- Torun A., Zerrouqi A., Ciechanowicz A., Ng T., Czystowska-Kuzmicz M. and Pyrzynska B.
- Conference:
- Journal of Extracellular Vesicles (Volume 11, Issue S1); ISEV2022 Abstract Book (year: 2022, volume: ISEV2022 Annual Meeting, pages: 165 (abstract PT07.07)), Publisher: International Society for Extracellular Vesicles (ISEV)
- Date:
- conference 25-29 maja 2022
- Status:
- Published
- DOI:
- 10.1002/jev2.12224 – link to the publication
-
Improvement of the anti-tumor activity of NK cells and the efficacy of anti-CD20 monoclonal antibodies in the therapy of B cell-derived malignancies.
- Authors:
- Zerrouqi A., Zdanowicz A., Torun A., Ciechanowicz A., Pradhan B., Rymkiewicz G., Efremov D., and Pyrzynska B.
- Conference:
- Cancer Research, Vol. 84 (6_Suppl) (year: 2024, volume: AACR Annual Meeting 2024, pages: Abstrakt nr 1344), Publisher: American Association for Cancer Research
- Date:
- conference 5-10 kwietnia 2024
- Status:
- Published
- DOI:
- 10.1158/1538-7445.AM2024-1344 – link to the publication
-
Potassium/sodium cation carriers robustly upregulate CD20 antigen by targeting MYC and synergize with anti-CD20 immunotherapies to eliminate malignant B cells.
- Authors:
- Pyrzynska B., Zerrouqi A., Zdanowicz A., Torun A., Pradhan B., Rymkiewicz G., Efremov D.
- Conference:
- European Journal of Cancer, Vol. 211, Suppl. 1, October 2024, 114994 (year: 2024, volume: 36th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, pages: 516LBA (PB-516) LBA Posters), Publisher: EORTC-NCI-AACR
- Date:
- conference 23-25 października 2024
- Status:
- Published
- DOI:
- 10.1016/j.ejca.2024.114994 – link to the publication