Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Identification and functional characteristics of mtDNA mutations in canine mammary gland tumors based on genomic, epigenomic and proteomic studies.

2019/35/B/NZ5/00775

Keywords:

canine tumors mtDNA mutations resequencing methylation proteomic profile ubiquitin

Descriptors:

  • NZ5_002:
  • NZ5_004:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Przyrodniczy w Lublinie

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Brygida Bożena Ślaska 

Number of co-investigators in the project: 10

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 1 856 040 PLN

Project start date (Y-m-d): 2020-09-29

Project end date (Y-m-d): 2025-09-28

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (20)
  1. Canis MitoSNP Database: a Functional Tool Useful for Comparative Analyses of Human and Canine Mitochondrial Genomes
    Authors:
    Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Marcin Jusiak, Ludmiła Grzybowska-Szatkowska, Brygida Ślaska
    Academic press:
    Journal of Applied Genetics (rok: 2023, tom: 64, strony: 515-520), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13353-023-00764-w - link to the publication
  2. Histopathological evaluation of canine mammary gland tumours: a study of 92 cases
    Authors:
    Angelika Tkaczyk-Wlizło, Anna Śmiech, Krzysztof Kowal, Dorota Różańska, Brygida Ślaska
    Academic press:
    Medycyna Weterynaryjna (rok: 2023, tom: 79, strony: 356-363), Wydawca: Medycyna Weterynaryjna
    Status:
    Published
    DOI:
    10.21521/mw.6771 - link to the publication
  3. Mitochondrial DNA alterations in the domestic dog (Canis lupus familiaris) and their association with development of diseases: A review
    Authors:
    AngelikaTkaczyk-Wlizło, Krzysztof Kowal, Brygida Ślaska
    Academic press:
    Mitochondrion (rok: 2022, tom: 63, strony: 72-84), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mito.2022.02.001 - link to the publication
  4. Molecular differences in mitochondrial genomes (mitogenomes) of dogs with recurrent and multiple tumours and their reference to the human mitochondrial genome
    Authors:
    Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Jan Gawor, Brygida Ślaska
    Academic press:
    Annnals of Animal Science (rok: 2024, tom: w trakcie recenzji, strony: w trakcie recenzji), Wydawca: De Gruyter Poland
    Status:
    Published
    DOI:
    10.2478/aoas-2023-0067 - link to the publication
  5. Evaluation of the tRNA-Leu (UUR) gene haplotype profile observed in canine mammary gland tumours based on comparative analysis with the MT-TL1 human gene
    Authors:
    Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Mariusz Pierzchała, Brygida Ślaska
    Academic press:
    Annnals of Animal Science (rok: 2021, tom: 22, strony: 915-922), Wydawca: De Gruyter Poland
    Status:
    Published
    DOI:
    10.2478/aoas-2022-0009 - link to the publication
  6. Evaluation of the tRNA-Leu (UUR) gene haplotype profile observed in canine mammary gland tumours based on comparative analysis with the MT-TL1 human gene
    Authors:
    Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Mariusz Pierzchała, Brygida Ślaska
    Academic press:
    Annnals of Animal Science (rok: 2021, tom: 22, strony: 915-922), Wydawca: De Gruyter Poland
    Status:
    Published
    DOI:
    10.2478/aoas-2022-0009 - link to the publication
  7. Evaluation of the tRNA-Leu (UUR) gene haplotype profile observed in canine mammary gland tumours based on comparative analysis with the MT-TL1 human gene
    Authors:
    Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Mariusz Pierzchała, Brygida Ślaska
    Academic press:
    Annals of Animal Science , Wydawca: De Gruyter Poland
    Status:
    Accepted for publication
    DOI:
    10.2478/aoas-2022-0009 - link to the publication
  8. Histopathological evaluation of canine mammary gland tumours: a study of 92 cases
    Authors:
    Angelika Tkaczyk-Wlizło, Anna Śmiech, Krzysztof Kowal, Dorota Różańska, Brygida Ślaska
    Academic press:
    Medycyna Weterynaryjna (rok: 2023, ), Wydawca: Medycyna Weterynaryjna
    Status:
    Submitted
  9. Mutations and polymorphisms in the mitochondrial genome of dogs with solid mammary carcinoma: A preliminary study.
    Authors:
    Kaja Ziółkowska, Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Anna Śmiech, Brygida Ślaska.
    Academic press:
    Medycyna Weterynaryjna (rok: 2023, tom: 79, strony: 566-572), Wydawca: Medycyna Weterynaryjna
    Status:
    Published
    DOI:
    10.21521/mw.6821 - link to the publication
  10. Occurrence of mammary gland tumours in male dogs and its weak association with development of testicular tumours: a review
    Authors:
    Tkaczyk-Wlizło Angelika; Kowal Krzysztof; Śmiech Anna, Ślaska Brygida
    Academic press:
    Journal of Applied Genetics (rok: 2023, tom: 65, strony: 137-153), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1007/s13353-023-00818-z - link to the publication
  11. Molecular differences in mitochondrial DNA (mtDNA) genomes of dogs with malignant mammary tumours
    Authors:
    Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Mariusz Pierzchała, Jan Gawor, Brygida Ślaska
    Academic press:
    Veterinary and Comparative Oncology (rok: 2021, tom: 20, strony: 256-264), Wydawca: John Wiley & Sons, Inc
    Status:
    Published
    DOI:
    10.1111/vco.12772 - link to the publication
  12. Canis MitoSNP Database: a Functional Tool Useful for Comparative Analyses of Human and Canine Mitochondrial Genomes
    Authors:
    Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Marcin Jusiak, Ludmiła Grzybowska-Szatkowska, Brygida Ślaska
    Academic press:
    Journal of Applied Genetics , Wydawca: Springer
    Status:
    Submitted
  13. Occurrence of mammary gland tumours in male dogs and its association with development of testicular tumours: A review
    Authors:
    Tkaczyk-Wlizło Angelika; Kowal Krzysztof; Śmiech Anna, Ślaska Brygida
    Academic press:
    Veterinary and Comparative Oncology (rok: 2023, ), Wydawca: Wiley
    Status:
    Submitted
  14. Molecular Differences in Mitochondrial Genomes (Mitogenomes) of Dogs with Recurrent and Multiple Tumours and Their Reference to the Human Mitochondrial Genome
    Authors:
    https://sciendo.com/article/10.2478/aoas-2023-0067
    Academic press:
    Annals of Animal Science (rok: 2024, tom: 1, strony: 89 - 97), Wydawca: De Gruyter Poland Sp. z o.o.
    Status:
    Published
    DOI:
    10.2478/aoas-2023-0067 - link to the publication
  15. Mitochondrial DNA alterations in the domestic dog (Canis lupus familiaris) and their association with development of diseases: A review
    Authors:
    AngelikaTkaczyk-Wlizło, Krzysztof Kowal, Brygida Ślaska
    Academic press:
    Mitochondrion (rok: 2022, tom: 63, strony: 72-84), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mito.2022.02.001 - link to the publication
  16. Mitochondrial DNA alterations in the domestic dog (Canis lupus familiaris) and their association with development of diseases: A review
    Authors:
    AngelikaTkaczyk-Wlizło, Krzysztof Kowal, Brygida Ślaska
    Academic press:
    Mitochondrion (rok: 2022, tom: 63, strony: 72-84), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mito.2022.02.001 - link to the publication
  17. Molecular differences in mitochondrial DNA (mtDNA) genomes of dogs with malignant mammary tumours
    Authors:
    Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Mariusz Pierzchała, Jan Gawor, Brygida Ślaska
    Academic press:
    Veterinary and Comparative Oncology (rok: 2021, tom: 20, strony: 256-264), Wydawca: John Wiley & Sons, Inc
    Status:
    Published
    DOI:
    10.1111/vco.12772 - link to the publication
  18. Molecular differences in mitochondrial genomes (mitogenomes) of dogs with recurrent and multiple tumours and their reference to the human mitochondrial genome
    Authors:
    Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Jan Gawor, Brygida Ślaska
    Academic press:
    Annnals of Animal Science (tom: w trakcie recenzji, strony: w trakcie recenzji), Wydawca: De Gruyter Poland
    Status:
    Submitted
  19. Molecular differences in mitochondrial DNA (mtDNA) genomes of dogs with malignant mammary tumours
    Authors:
    Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Mariusz Pierzchała, Jan Gawor, Brygida Ślaska
    Academic press:
    Veterinary and Comparative Oncology (rok: 2021, tom: 20, strony: 256-264), Wydawca: John Wiley & Sons, Inc
    Status:
    Published
    DOI:
    10.1111/vco.12772 - link to the publication
  20. Evaluation of the tRNA-Leu (UUR) gene haplotype profile observed in canine mammary gland tumours based on comparative analysis with the MT-TL1 human gene
    Authors:
    Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Mariusz Pierzchała, Brygida Ślaska
    Academic press:
    Annals of Animal Science , Wydawca: De Gruyter Poland
    Status:
    Accepted for publication
    DOI:
    10.2478/aoas-2022-0009 - link to the publication

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