Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Ecto-enzymes in interactions of vascular endothelium with blood circulating cells in physiology, pathology and therapy; could cells exchange their ecto-enzymes?

2019/35/D/NZ3/03512

Keywords:

ecto-enzymes endothelium intercellular interactions cardiovascular diseases cancer

Descriptors:

  • NZ3_002:
  • NZ1_002:
  • NZ4_004:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Lekarski

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Barbara Anna Kutryb-Zając 

Number of co-investigators in the project: 9

Call: SONATA 15 - announced on 2019-09-16

Amount awarded: 1 498 740 PLN

Project start date (Y-m-d): 2020-07-02

Project end date (Y-m-d): 2024-07-01

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (19)
  1. CoCl2-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors
    Authors:
    Barbara Kutryb-Zajac,1 Ada Kawecka, Alicja Braczko, Marika Franczak, Ewa M. Slominska, Roberto Giovannoni, Ryszard T. Smolenski
    Academic press:
    Biomedicines (rok: 2022, tom: 10(7), strony: 1540), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines10071540 - link to the publication
  2. Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases
    Authors:
    Barbara Kutryb-Zajac, Paulina Mierzejewska, Ewa M. Slominska, Ryszard T. Smolenski
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 4652), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25204652 - link to the publication
  3. Metabolic Pattern of Systemic Sclerosis: Association of Changes in Plasma Concentrations of Amino Acid-Related Compounds With Disease Presentation
    Authors:
    Zaneta Smolenska, Magdalena Zabielska-Kaczorowska, Anna Wojteczek, Barbara Kutryb-Zajac, Zbigniew Zdrojewski
    Academic press:
    Frontiers in Molecular Biosciences (rok: 2020, tom: 7, strony: 585161), Wydawca: Frontiers Media S.A
    Status:
    Published
    DOI:
    10.3389/fmolb.2020.585161 - link to the publication
  4. Endothelial effects of simultaneous expression of human HO-1, E5NT, and ENTPD1 in a mouse
    Authors:
    Paulina Mierzejewska; Noemi Di Marzo; Magdalena A. Zabielska-Kaczorowska; Iga Walczak; Ewa M. Slominska; Marialuisa Lavitrano; Roberto Giovannoni; Barbara Kutryb-Zajac; Ryszard T. Smolenski
    Academic press:
    Pharmaceuticals (rok: 2023, tom: 16(10), strony: 1409), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph16101409 - link to the publication
  5. Metabolic Pattern of Systemic Sclerosis: Association of Changes in Plasma Concentrations of Amino Acid-Related Compounds With Disease Presentation
    Authors:
    Zaneta Smolenska, Magdalena Zabielska-Kaczorowska, Anna Wojteczek, Barbara Kutryb-Zajac, Zbigniew Zdrojewski
    Academic press:
    Frontiers in Molecular Biosciences (rok: 2020, tom: 7, strony: 585161), Wydawca: Frontiers Media S.A
    Status:
    Published
    DOI:
    10.3389/fmolb.2020.585161 - link to the publication
  6. The impaired distribution of adenosine deaminase isoenzymes in multiple sclerosis plasma and cerebrospinal fluid
    Authors:
    Barbara Kutryb-Zajac, Ada Kawecka, Fionä Caratis, Krzysztof Urbanowicz, Alicja Braczko, Tomomi Furihata, Bartosz Karaszewski, Ryszard T. Smolenski, Aleksandra Rutkowska
    Academic press:
    Frontiers in Molecular Neuroscience (rok: 2022, tom: 15, strony: 998023), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnmol.2022.998023 - link to the publication
  7. Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases
    Authors:
    Barbara Kutryb-Zajac, Paulina Mierzejewska, Ewa M. Slominska, Ryszard T. Smolenski
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 4652), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25204652 - link to the publication
  8. Blocking cholesterol formation and turnover improves cellular and mitochondria function in murine heart microvascular endothelial cells and cardiomyocytes
    Authors:
    Alicja Braczko, Gabriela Harasim, Ada Kawecka, Iga Walczak, KapustaMałgorzata Kapusta, Magdalena Narajczyk, Klaudia Stawarska, Ryszard T. Smoleński, Barbara Kutryb-Zając
    Academic press:
    Frontiers in Physiology (rok: 2023, tom: 14, strony: 1216267), Wydawca: Frontiers Media S.A
    Status:
    Published
    DOI:
    10.3389/fphys.2023.1216267 - link to the publication
  9. Changes in Adenosine Deaminase Activity and Endothelial Dysfunction after Mild Coronavirus Disease-2019
    Authors:
    Agata Jedrzejewska, Ada Kawecka, Alicja Braczko, Marzena Romanowska-Kocejko, Klaudia Stawarska, Milena Deptuła, Małgorzata Zawrzykraj, Marika Franczak, Oliwia Krol, Gabriela Harasim, Iga Walczak, Michał Pikuła, Marcin Hellmann, Barbara Kutryb-Zajac
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24(17), strony: 13140), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms241713140 - link to the publication
  10. Macrophage-Derived Adenosine Deaminase 2 Correlates with M2 Macrophage Phenotype in Triple Negative Breast Cancer
    Authors:
    Barbara Kutryb-Zajac, Gabriela Harasim, Agata Jedrzejewska, Oliwia Krol, Alicja Braczko, Patrycja Jablonska, Paulina Mierzejewska, Jacek Zielinski, Ewa M. Slominska, Ryszard. T. Smolenski
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 3764), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3390/ijms22073764 - link to the publication
  11. The impaired distribution of adenosine deaminase isoenzymes in multiple sclerosis plasma and cerebrospinal fluid
    Authors:
    Barbara Kutryb-Zajac, Ada Kawecka, Fionä Caratis, Krzysztof Urbanowicz, Alicja Braczko, Tomomi Furihata, Bartosz Karaszewski, Ryszard T. Smolenski, Aleksandra Rutkowska
    Academic press:
    Frontiers in Molecular Neuroscience (rok: 2022, tom: 15, strony: 998023), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnmol.2022.998023 - link to the publication
  12. Cardiac Mitochondria Dysfunction in Dyslipidemic Mice
    Authors:
    Alicja Braczko, Barbara Kutryb-Zając, Agata Jędrzejewska, Oliwia Król, Paulina Mierzejewska, Magdalena Zabielska-Kaczorowska, Ewa M. Słomińska, Ryszard T. Smoleński
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(19), strony: 11488), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms231911488 - link to the publication
  13. Macrophage-Derived Adenosine Deaminase 2 Correlates with M2 Macrophage Phenotype in Triple Negative Breast Cancer
    Authors:
    Barbara Kutryb-Zajac, Gabriela Harasim, Agata Jedrzejewska, Oliwia Krol, Alicja Braczko, Patrycja Jablonska, Paulina Mierzejewska, Jacek Zielinski, Ewa M. Slominska, Ryszard. T. Smolenski
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 3764), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3390/ijms22073764 - link to the publication
  14. Macrophage-Derived Adenosine Deaminase 2 Correlates with M2 Macrophage Phenotype in Triple Negative Breast Cancer
    Authors:
    Barbara Kutryb-Zajac, Gabriela Harasim, Agata Jedrzejewska, Oliwia Krol, Alicja Braczko, Patrycja Jablonska, Paulina Mierzejewska, Jacek Zielinski, Ewa M. Slominska, Ryszard. T. Smolenski
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 3764), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3390/ijms22073764 - link to the publication
  15. Cardiac Mitochondria Dysfunction in Dyslipidemic Mice
    Authors:
    Alicja Braczko, Barbara Kutryb-Zając, Agata Jędrzejewska, Oliwia Król, Paulina Mierzejewska, Magdalena Zabielska-Kaczorowska, Ewa M. Słomińska, Ryszard T. Smoleński
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(19), strony: 11488), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms231911488 - link to the publication
  16. Drugs targeting adenosine signaling pathways: A current view
    Authors:
    Barbara Kutryb-Zając, Ada Kawecka, Khrystyna Nasadiuk, Alicja Braczko, Klaudia Stawarska, Elisabetta Caiazzo, Patrycja Koszałka, Carla Cicala
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2023, tom: 165, strony: 115184), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2023.115184 - link to the publication
  17. CoCl2-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors
    Authors:
    Barbara Kutryb-Zajac,1 Ada Kawecka, Alicja Braczko, Marika Franczak, Ewa M. Slominska, Roberto Giovannoni, Ryszard T. Smolenski
    Academic press:
    Biomedicines (rok: 2022, tom: 10(7), strony: 1540), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines10071540 - link to the publication
  18. Metabolic Pattern of Systemic Sclerosis: Association of Changes in Plasma Concentrations of Amino Acid-Related Compounds With Disease Presentation
    Authors:
    Zaneta Smolenska, Magdalena Zabielska-Kaczorowska, Anna Wojteczek, Barbara Kutryb-Zajac, Zbigniew Zdrojewski
    Academic press:
    Frontiers in Molecular Biosciences (rok: 2020, tom: 7, strony: 585161), Wydawca: Frontiers Media S.A
    Status:
    Published
    DOI:
    10.3389/fmolb.2020.585161 - link to the publication
  19. Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases
    Authors:
    Barbara Kutryb-Zajac, Paulina Mierzejewska, Ewa M. Slominska, Ryszard T. Smolenski
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 4652), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25204652 - link to the publication

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