Projects funded by the NCN
Structural insights into the involvement of the RNA degradosome in trans-translation in the light of the antimicrobial activity of pyrazinamide – perspectives for anti(myco)bacterial drug discovery.
2019/34/E/NZ1/00338
Keywords:
tuberculosis RNA metabolism RNA degradosome pyrazinamide and pyrazinamide derivatives novel antibiotics Mycobacterium tuberculosis
Descriptors:
- NZ1_010:
- NZ6_004:
- NZ1_001:
Panel:
NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Principal investigator (from the host institution):
Number of co-investigators in the project: 7
Call: SONATA BIS 9 - announced on 2019-06-17
Amount awarded: 2 999 000 PLN
Project start date (Y-m-d): 2020-10-01
Project end date (Y-m-d): 2025-09-30
Project duration:: 60 months (the same as in the proposal)
Project status: Pending project
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Depletion of tRNA CCA-adding enzyme in Mycobacterium tuberculosis leads to polyadenylation of transcripts and precursor tRNAsAuthors:Błaszczyk E, Płociński P, Lechowicz E, Brzostek A, Dziadek B, Korycka-Machała M, Słomka M, Dziadek JAcademic press:Scientific Reports (rok: 2023, tom: 13(1):20717, strony: 45669), Wydawca: Nature Publishing GroupStatus:PublishedDOI:10.1038/s41598-023-47944-6 - link to the publication