Projects search

Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates Toxic for FGFR1-Overproducing Cancers

Authors:

Natalia Porębska, Agata Knapik, Marta Poźniak, Mateusz Adam Krzyścik, Małgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński

Academic press:

Biomacromolecules (year: 2021, volume: 22, pages: 5349–5362), Publisher: ACS

Status:

Published

DOI:

10.1021/acs.biomac.1c01280 – link to the publication

FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance

Authors:

Jakub Szymczyk, Katarzyna Dominika Sluzalska, Izabela Materla, Lukasz Opalinski, Jacek Otlewski, Malgorzata Zakrzewska

Academic press:

Cancers (year: 2021, volume: 12, pages: 5796), Publisher: MDPI

Status:

Published

DOI:

10.3390/cancers13225796 – link to the publication

Galectins as modulators of receptor tyrosine kinases signaling in health and disease

Authors:

Natalia Porębska, Marta Poźniak, Aleksandra Matynia, Dominika Żukowska, Małgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński

Academic press:

Cytokine Growth Factor Reviews (year: 2021, volume: 60, pages: 89-106), Publisher: ELSEVIER

Status:

Published

DOI:

10.1016/j.cytogfr.2021.03.004 – link to the publication

Development of Galectin-7-Specific Nanobodies: Implications for Immunotherapy and Molecular Imaging in Cancer

Authors:

Rita Nehmé, Marlène Fortier, Myriam Létourneau, Camille Fuselier, Philippine Granger, Joly de Boissel, Alyssa Dumoulin, Brigitte GuérinVéronique, Dumulon-Perreault, Samia Ait-Mohand, Otman Sarrhini, Sacha T. Larda, Yarileny Castellanos, Villamizar, Mighel Bernier, Natalia Porębska, Łukasz Opaliński, David Chatenet, Nicolas Doucet, Yves St-Pierre

Academic press:

Journal of Medicinal Chemistry (year: 2025, volume: 68, pages: 8484-8496), Publisher: ACS

Status:

Published

DOI:

10.1021/acs.jmedchem.5c00071 – link to the publication

Dissecting the specificity of sugar code recognition - Unleashing the biomedical potential of galectins by protein engineering

Authors:

Marta Kalka , Julia Ptak , Paulina Gregorczyk , Krzysztof Ciura , Aleksandra Chorążewska , Subhradeep Haldar , Natalia Porębska , Ewa Marcinkowska , Łukasz Opaliński

Academic press:

Biotechnology Advances (year: 2025, volume: 84, pages: 108681), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.biotechadv.2025.108681 – link to the publication

The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases

Authors:

Marta Poźniak, Dominika Żukowska, Aleksandra Gędaj, Mateusz Adam Krzyścik, Natalia Porębska, Małgorzata Zakrzewska, Jacek Otlewski and Łukasz Opaliński

Academic press:

International Journal of Molecular Sciences (year: 2022, volume: 23, pages: 8514), Publisher: MDPI

Status:

Published

DOI:

10.3390/ijms23158514 – link to the publication

FGF1 protects FGFR1-overexpressing cancer cells against drugs targeting tubulin polymerization by activating AKT via two independent mechanisms

Authors:

Jakub Szymczyk, Martyna Sochacka, Patryk Chudy, Lukasz Opalinski, Jacek Otlewski, Malgorzata Zakrzewska

Academic press:

Frontiers in Oncology (year: 2022, volume: 12, pages: 1011762), Publisher: Frontiers

Status:

Published

DOI:

10.3389/fonc.2022.1011762 – link to the publication

Thermostable phenylacetic acid degradation protein TtPaaI from Thermus thermophilus as a scaffold for tetravalent display of proteins

Authors:

Aleksandra Chorązewska, Darragh Regan, Marta Kalka, Krzysztof Ciura, Natalia Porębska, Łukasz Opaliński

Academic press:

Protein Expression and Purification (year: 2025, volume: 227, pages: 106623), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.pep.2024.106623 – link to the publication

Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling

Authors:

Gędaj A, Żukowska D, Porębska N, Pozniak M, Krzyścik M, Czyrek A, Krowarsch D, Zakrzewska M, Otlewski J, Opaliński Ł

Academic press:

Cell Communication and Signaling (year: 2023, volume: 21(1), pages: 122), Publisher: BMC

Status:

Published

DOI:

10.1186/s12964-023-01144-x – link to the publication

N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope

Authors:

Gregorczyk P, Porebska N, Zukowska D, Chorazewska A, Gedaj A, Malinowska A, Otlewski J, Zakrzewska M, Opalinski Ł

Academic press:

Cell Communication and Signaling (year: 2023, volume: 21 (1), pages: 177), Publisher: BMC

Status:

Published

DOI:

10.1186/s12964-023-01203-3 – link to the publication

The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis

Authors:

Żukowska D, Chorążewska A, Ciura K, Gędaj A, Kalka M, Poźniak M, Porębska N, Opaliński Ł.

Academic press:

Cell Communication and Signaling (year: 2024, volume: 22(1), pages: 270), Publisher: Springer Nature

Status:

Published

DOI:

10.1186/s12964-024-01661-3 – link to the publication

Share Engineered intrinsically fluorescent galectin-8 variants with altered valency, ligand recognition and biological activity

Authors:

Kalka M, Chorążewska A, Gędaj A, Żukowska D, Ciura K, Biaduń M, Gregorczyk P, Ptak J, Porębska N, Opaliński Ł.

Academic press:

International Journal of Biological Macromolecules (year: 2024, volume: 277, pages: 134371), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.ijbiomac.2024.134371 – link to the publication

Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling

Authors:

Zukowska D, Gedaj A, Porebska N, Pozniak M, Krzyscik M, Czyrek A, Krowarsch D, Zakrzewska M, Otlewski J, Opalinski Ł

Academic press:

Cellular and Molecular Life Sciences (year: 2023, volume: 80 (4), pages: 113), Publisher: Springer

Status:

Published

DOI:

10.1007/s00018-023-04768-x – link to the publication

Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs

Authors:

Gędaj A, Gregorczyk P, Żukowska D, Chorążewska A, Ciura K, Kalka M, Porębska N, Opaliński Ł

Academic press:

Cytokines and Growth Factor Reviews (year: 2024, volume: 77, pages: 39-55), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.cytogfr.2024.04.001 – link to the publication

Cyclic and dimeric fibroblast growth factor 2 variants with high biomedical potential

Authors:

Mateusz Krzyscik, Łukasz Opaliński, Jacek Otlewski

Academic press:

International Journal of Biological Macromolecules (year: 2022, volume: 215, pages: 243-258), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.ijbiomac.2022.07.105 – link to the publication

The intracellular interplay between galectin-1 and FGF12 in the assembly of ribosome biogenesis complex

Authors:

Gędaj A, Chorążewska A, Ciura K, Karelus R, Żukowska D, Biaduń M, Kalka M, Zakrzewska M, Porębska N, Opaliński Ł.

Academic press:

Cell Communication and Signaling (year: 2024, volume: 22, pages: 175), Publisher: Springer Nature

Status:

Published

DOI:

10.1186/s12964-024-01558-1 – link to the publication

Multilayered N-glycosylation dependent control of FGF/FGFR signaling and cell fate by extracellular galectins

Authors:

Zukowska D, Gedaj A, Gregorczyk P, Pozniak M, Porebska N, Opalinski L

Conference:

EACR 2023 Congress Abstracts (year: 2023, volume: EACR Congress 2023, pages: 109), Publisher: FEBS PRESS

Date:

conference 12.06.2023-15.06.2023

Status:

Published

DOI:

10.1002/1878-0261.13469 – link to the publication