Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Extracellular galectins as controllers of fibroblast growth factor receptor signaling

2019/34/E/NZ3/00014

Keywords:

FGFR FGF galectin glycosylation signaling receptors protein transport endocytosis cell proliferation apoptosis migration glucose metabolism cancer

Descriptors:

  • NZ3_007:
  • NZ3_001:
  • NZ3_003:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Łukasz Opaliński 

Number of co-investigators in the project: 5

Call: SONATA BIS 9 - announced on 2019-06-17

Amount awarded: 2 657 400 PLN

Project start date (Y-m-d): 2020-10-01

Project end date (Y-m-d): 2025-09-30

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (15)
  • Articles in post-conference publications (1)
  1. The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis
    Authors:
    Żukowska D, Chorążewska A, Ciura K, Gędaj A, Kalka M, Poźniak M, Porębska N, Opaliński Ł.
    Academic press:
    Cell Communication and Signaling (rok: 2024, tom: 22(1), strony: 270), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-024-01661-3. - link to the publication
  2. Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling
    Authors:
    Zukowska D, Gedaj A, Porebska N, Pozniak M, Krzyscik M, Czyrek A, Krowarsch D, Zakrzewska M, Otlewski J, Opalinski Ł
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2023, tom: 80 (4), strony: 113), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-023-04768-x - link to the publication
  3. Galectins as modulators of receptor tyrosine kinases signaling in health and disease
    Authors:
    Natalia Porębska, Marta Poźniak, Aleksandra Matynia, Dominika Żukowska, Małgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
    Academic press:
    Cytokine Growth Factor Reviews (rok: 2021, tom: 60, strony: 89-106), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.cytogfr.2021.03.004 - link to the publication
  4. FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance
    Authors:
    Jakub Szymczyk, Katarzyna Dominika Sluzalska, Izabela Materla, Lukasz Opalinski, Jacek Otlewski, Malgorzata Zakrzewska
    Academic press:
    Cancers (rok: 2021, tom: 12, strony: 5796), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13225796 - link to the publication
  5. The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases
    Authors:
    Marta Poźniak, Dominika Żukowska, Aleksandra Gędaj, Mateusz Adam Krzyścik, Natalia Porębska, Małgorzata Zakrzewska, Jacek Otlewski and Łukasz Opaliński
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 8514), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23158514 - link to the publication
  6. Share Engineered intrinsically fluorescent galectin-8 variants with altered valency, ligand recognition and biological activity
    Authors:
    Kalka M, Chorążewska A, Gędaj A, Żukowska D, Ciura K, Biaduń M, Gregorczyk P, Ptak J, Porębska N, Opaliński Ł.
    Academic press:
    International Journal of Biological Macromolecules (rok: 2024, tom: 277, strony: 134371), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2024.134371 - link to the publication
  7. FGF1 protects FGFR1-overexpressing cancer cells against drugs targeting tubulin polymerization by activating AKT via two independent mechanisms
    Authors:
    Jakub Szymczyk, Martyna Sochacka, Patryk Chudy, Lukasz Opalinski, Jacek Otlewski, Malgorzata Zakrzewska
    Academic press:
    Frontiers in Oncology (rok: 2022, tom: 12, strony: 1011762), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2022.1011762 - link to the publication
  8. Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling
    Authors:
    Gędaj A, Żukowska D, Porębska N, Pozniak M, Krzyścik M, Czyrek A, Krowarsch D, Zakrzewska M, Otlewski J, Opaliński Ł
    Academic press:
    Cell Communication and Signaling (rok: 2023, tom: 21(1), strony: 122), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12964-023-01144-x. - link to the publication
  9. Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs
    Authors:
    Gędaj A, Gregorczyk P, Żukowska D, Chorążewska A, Ciura K, Kalka M, Porębska N, Opaliński Ł
    Academic press:
    Cytokines and Growth Factor Reviews (rok: 2024, tom: 77, strony: 39-55), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cytogfr.2024.04.001 - link to the publication
  10. Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates Toxic for FGFR1-Overproducing Cancers
    Authors:
    Natalia Porębska, Agata Knapik, Marta Poźniak, Mateusz Adam Krzyścik, Małgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
    Academic press:
    Biomacromolecules (rok: 2021, tom: 22, strony: 5349–5362), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.biomac.1c01280 - link to the publication
  11. Cyclic and dimeric fibroblast growth factor 2 variants with high biomedical potential
    Authors:
    Mateusz Krzyscik, Łukasz Opaliński, Jacek Otlewski
    Academic press:
    International Journal of Biological Macromolecules (rok: 2022, tom: 215, strony: 243-258), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2022.07.105 - link to the publication
  12. The intracellular interplay between galectin-1 and FGF12 in the assembly of ribosome biogenesis complex
    Authors:
    Gędaj A, Chorążewska A, Ciura K, Karelus R, Żukowska D, Biaduń M, Kalka M, Zakrzewska M, Porębska N, Opaliński Ł.
    Academic press:
    Cell Communication and Signaling (rok: 2024, tom: 22, strony: 175), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-024-01558-1 - link to the publication
  13. Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling
    Authors:
    Gędaj A, Żukowska D, Porębska N, Pozniak M, Krzyścik M, Czyrek A, Krowarsch D, Zakrzewska M, Otlewski J, Opaliński Ł
    Academic press:
    Cell Communication and Signaling (rok: 2023, tom: 21(1), strony: 122), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12964-023-01144-x. - link to the publication
  14. N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope
    Authors:
    Gregorczyk P, Porebska N, Zukowska D, Chorazewska A, Gedaj A, Malinowska A, Otlewski J, Zakrzewska M, Opalinski Ł
    Academic press:
    Cell Communication and Signaling (rok: 2023, tom: 21 (1), strony: 177), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12964-023-01203-3 - link to the publication
  15. Share Engineered intrinsically fluorescent galectin-8 variants with altered valency, ligand recognition and biological activity
    Authors:
    Kalka M, Chorążewska A, Gędaj A, Żukowska D, Ciura K, Biaduń M, Gregorczyk P, Ptak J, Porębska N, Opaliński Ł.
    Academic press:
    International Journal of Biological Macromolecules (rok: 2024, tom: 277, strony: 134371), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2024.134371 - link to the publication
  1. Multilayered N-glycosylation dependent control of FGF/FGFR signaling and cell fate by extracellular galectins
    Authors:
    Zukowska D, Gedaj A, Gregorczyk P, Pozniak M, Porebska N, Opalinski L
    Conference:
    EACR 2023 Congress Abstracts (rok: 2023, tom: EACR Congress 2023, strony: 109), Wydawca: FEBS PRESS
    Data:
    konferencja 12.06.2023-15.06.2023
    Status:
    Published
    DOI:
    10.1002/1878-0261.13469 - link to the publication

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