Projects funded by the NCN
Targeting of hypoxic cancer cells for imaging
2019/33/B/NZ7/02980
Keywords:
cancer optical imaging hypoxia nitroreductase cytotoxicity in vitro spheroids in vivo nitro(hetero)cyclic compounds transferrin gold nanoparticles ruthenium compounds
Descriptors:
- NZ7_014:
- ST4_009:
- NZ3_001:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Uniwersytet Jagielloński, Wydział Chemii
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 13
Call: OPUS 17 - announced on 2019-03-15
Amount awarded: 1 278 024 PLN
Project start date (Y-m-d): 2020-02-20
Project end date (Y-m-d): 2024-02-19
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (6)
- Bioconjugation of holo-transferrin with hypoxia-enhanced fluorescent sensor for the selective imaging of cancer cellsAuthors:E. Janczy-Cempa, A. Kwiatkowska, O. Mazuryk, N. Chopin, M.-A. Hiebel, F. Suzenet*, M. Brindell*Academic press:Sensors & Actuators B Chem. (rok: 2023, tom: 394, art. 134450, strony: 45668), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.snb.2023.134450 - link to the publication
- Nitro-Pyrazinotriazapentalene scaffolds– nitroreductase quantification and in vitro fluorescence imaging of hypoxiaAuthors:Ewelina Janczy-Cempa, Olga Mazuryk, Doina Sirbu, Nicolas Chopin, Magdalena Żarnik, Magdalena Zastawna, Cyril Colas, Marie-Aude Hiebel, Franck Suzenet, Małgorzata BrindellAcademic press:Sensors and Actuators: B. Chemical (rok: 2021, tom: 346 art. 130504, strony: 45668), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.snb.2021.130504 - link to the publication
- Nitro-Pyrazinotriazapentalene scaffolds– nitroreductase quantification and in vitro fluorescence imaging of hypoxiaAuthors:Ewelina Janczy-Cempa, Olga Mazuryk, Doina Sirbu, Nicolas Chopin, Magdalena Żarnik, Magdalena Zastawna, Cyril Colas, Marie-Aude Hiebel, Franck Suzenet, Małgorzata BrindellAcademic press:Sensors and Actuators: B. Chemical (rok: 2021, tom: 346 art. 130504, strony: 45668), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.snb.2021.130504 - link to the publication
- Significance of Specific Oxidoreductases in the Design of Hypoxia-Activated Prodrugs and Fluorescent Turn off–on Probes for Hypoxia ImagingAuthors:E. Janczy-Cempa, O. Mazuryk, A. Kania, M. BrindellAcademic press:Cancers (rok: 2022, tom: 14, art. 2686, strony: 45683), Wydawca: MDPIStatus:PublishedDOI:10.3390/cancers14112686 - link to the publication
- Significance of Specific Oxidoreductases in the Design of Hypoxia-Activated Prodrugs and Fluorescent Turn off–on Probes for Hypoxia ImagingAuthors:E. Janczy-Cempa, O. Mazuryk, A. Kania, M. BrindellAcademic press:Cancers (rok: 2022, tom: 14, art. 2686, strony: 45683), Wydawca: MDPIStatus:PublishedDOI:10.3390/cancers14112686 - link to the publication
- Nitro-Pyrazinotriazapentalene scaffolds– nitroreductase quantification and in vitro fluorescence imaging of hypoxiaAuthors:Ewelina Janczy-Cempa, Olga Mazuryk, Doina Sirbu, Nicolas Chopin, Magdalena Żarnik, Magdalena Zastawna, Cyril Colas, Marie-Aude Hiebel, Franck Suzenet, Małgorzata BrindellAcademic press:Sensors and Actuators: B. Chemical (rok: 2021, tom: 346 art. 130504, strony: 45668), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.snb.2021.130504 - link to the publication