Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Gut microbiota dependent modulation of therapeutic response and side effects to irinotecan and new camptothecin analogues

2018/31/B/NZ7/02675

Keywords:

cancer micorbiome metabolome 16SrRNA-Seq mass spectrometry nmr irinotecan

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ2_4: Metabolomics
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jerzy Ostrowski 

Number of co-investigators in the project: 15

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 985 598 PLN

Project start date (Y-m-d): 2019-07-26

Project end date (Y-m-d): 2024-07-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. A NMR study of binding the metabolite of SN38 derivatives to a model nicked DNA decamer mimicking target of Topo I inhibitors
    Authors:
    Beata Naumczuk, Jerzy Sitkowski, Wojciech Bocian, Magdalena Stolarska, Elżbieta Bednarek, Lech Kozerski
    Academic press:
    Bioorganic Chemistry (rok: 2021, tom: 107, strony: 104631), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2021.104631 - link to the publication
  2. The Mode of SN38 Derivatives Interacting with Nicked DNA Mimics Biological Targeting of Topo I Poisons
    Authors:
    Wojciech Bocian, Beata Naumczuk, Magdalena Urbanowicz, Jerzy Sitkowski, Anna Bierczyńska-Krzysik, Elżbieta Bednarek, Katarzyna Wiktorska, Małgorzata Milczarek, Lech Kozerski
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 7471), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication

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