Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The importance of MLK4 signalling in the communication between breast cancer cells and tumour-associated macrophages.

2018/31/D/NZ5/01274

Keywords:

MLK4 tumour microenvironment macrophages

Descriptors:

  • NZ5_3:
  • NZ3_7:
  • NZ3_1:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Agnieszka Marusiak 

Number of co-investigators in the project: 3

Call: SONATA 14 - announced on 2018-09-14

Amount awarded: 1 303 400 PLN

Project start date (Y-m-d): 2019-07-11

Project end date (Y-m-d): 2023-02-10

Project duration:: 43 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Protocols for Co-Culture Phenotypic Assays with Breast Cancer Cells and THP-1-Derived Macrophages
    Authors:
    Alicja Mazan, Anna Marusiak
    Academic press:
    Journal of Mammary Gland Biololgy and Neoplasia (rok: 2024, tom: 29;4, strony: brak), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s10911-024-09556-2 - link to the publication
  2. Inhibition of the ʟ-glutamine transporter ASCT2 sensitizes plasma cell myeloma cells to proteasome inhibitors
    Authors:
    Monika K Prelowska, Dawid Mehlich, M Talha Ugurlu, Hanna Kedzierska, Aleksandra Cwiek, Artur Kosnik, Klaudia Kaminska, Anna A Marusiak, Dominika Nowis
    Academic press:
    Cancer Letters (rok: 2021, tom: ahead of print, strony: ahead of print), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.canlet.2021.02.020 - link to the publication
  3. MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance
    Authors:
    Mehlich D, Łomiak M, Sobiborowicz A, Mazan A, Dymerska D, Szewczyk LM, Mehlich A, Borowiec A, Prełowska MK, Gorczynski A, Jabłoński P, Iżycka-Świeszewska E, Nowis D, Anna A. Marusiak AA
    Academic press:
    Cell Death and Disease (rok: 2021, tom: 10, strony: brak), Wydawca: Nature Springer Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41419-021-04405-0 - link to the publication

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