Projects funded by the NCN
Diet and human gut microbiome as sources of N-acyl amines acting as GPCR ligands.
2018/28/C/NZ9/00171
Keywords:
N-acyl amines N-acyl amino acids insulin GLP-1 diabetes GPR119 GPR55 GPR40 rapeseed oil olive oil gut microbiome Bacteroidales ligand-receptor interactions
Descriptors:
- NZ9_7: Nutrition and food sciences
- NZ5_1: Etiology of human diseases
- NZ3_7: Signal transduction
Panel:
NZ9 - Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation
Host institution :
Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności
woj. łódzkie
Principal investigator (from the host institution):
Number of co-investigators in the project: 1
Call: SONATINA 2 - announced on 2017-12-15
Amount awarded: 882 781 PLN
Project start date (Y-m-d): 2018-10-22
Project end date (Y-m-d): 2023-10-21
Project duration:: 60 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (3)
- Isoprenoid Derivatives of Lysophosphatidylcholines Enhance Insulin and GLP-1 Secretion through Lipid-Binding GPCRsAuthors:Anna Drzazga, Daria Kamińska, Anna Gliszczyńska, Edyta Gendaszewska-DarmachAcademic press:International Journal of Molecular Sciences (rok: 2021, tom: 22(11), strony: 5748-66), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms22115748 - link to the publication
- Unsaturated N-acyl glycines produced by commensal bacteria potentiate glucagon-like peptide 1 secretion in enteroendocrine L cells of the gut as GPCR ligandsAuthors:Anna Drzazga (autor korespondencyjny), Przemysław Bernat, Adriana Nowak, Marcin Szustak, Eliza Korkus, Edyta Gendaszewska-Darmach, Maria KoziołkiewiczAcademic press:Food Research International , Wydawca: ElsevierStatus:SubmittedDOI:brak - link to the publication
- Targeting GPCRs Activated by Fatty Acid-Derived Lipids in Type 2 DiabetesAuthors:Edyta Gendaszewska-Darmach, Anna Drzazga, Maria KoziołkiewiczAcademic press:Trends in molecular medicine (rok: 2019, tom: 25(10), strony: 915-929), Wydawca: ELSEVIER SCI LTDStatus:PublishedDOI:10.1016/j.molmed.2019.07.003 - link to the publication