Projects funded by the NCN
CD73 (ecto-5'-nucleotidase) function in breast cancer progression and promotion, and its assessment as a therapeutic target.
2017/27/B/NZ5/02192
Keywords:
CD73 ecto-5'-nucleotidase breast cancer CD73 knockout chemical cancerogenesis cancer progression cancer promotion
Descriptors:
- NZ5_4:
- NZ5_7:
- NZ1_1:
Panel:
NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution :
Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego
woj. pomorskie
Principal investigator (from the host institution):
dr hab. Patrycja Małgorzata Koszałka
Number of co-investigators in the project: 5
Call: OPUS 14 - announced on 2017-09-15
Amount awarded: 1 286 240 PLN
Project start date (Y-m-d): 2018-10-02
Project end date (Y-m-d): 2023-10-01
Project duration:: 60 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Knock-out of CD73 delays the onset of HR-negative breast cancer by reprogramming lipid metabolism and is associated with increased tumor mutational burdenAuthors:Paweł Kamil Serafin, Marta Popęda, Kamila Bulak, Agata Zwara, Barbara Galikowska-Bogut, Anna Przychodzka, Adriana Mika, Tomasz Śledziński, Marcin Stanisławowski, Kamila Jendernalik, Marika Bolcewicz, Wiktoria Laprus, Grzegorz Stasiłojć, Rafał Sądej, Anna Żaczek, Leszek Kalinowski, Patrycja KoszałkaAcademic press:Molecular Metabolism (rok: 2024, tom: 89, strony: 19), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.molmet.2024.102035 - link to the publication