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Information of the project and the call

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Head and neck squamous cell carcinoma (HNSCC)-derived exosomes re-programm the tumor microenvironment for neoangiogenesis and tumor progression in vitro and in vivo

2017/26/M/NZ5/00877

Keywords:

head and neck squamous cell cancer angiogenesis tumor microenvironment

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Mirosław Szczepański 

Number of co-investigators in the project: 7

Call: HARMONIA 9 - announced on 2017-06-14

Amount awarded: 1 162 000 PLN

Project start date (Y-m-d): 2018-04-10

Project end date (Y-m-d): 2023-04-09

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  1. CD44(+) tumor cells promote early angiogenesis in head and neck squamous cell carcinoma.
    Authors:
    Ludwig N, Szczepanski MJ, Gluszko A, Szafarowski T, Azambuja JH, Dolg L, Gellrich NC, Kampmann A, Whiteside TL, Zimmerer RM.
    Academic press:
    Cancer Letters (rok: 2019, tom: 467, strony: 85-95), Wydawca: ScienceDirect
    Status:
    Published
    DOI:
    10.010 - link to the publication
  2. Microvessel density in head and neck squamous cell carcinoma
    Authors:
    Tomasz Szafarowski, Janusz Sierdzinski, Miroslaw J. Szczepanski, Theresa L. Whiteside, Nils Ludwig, Antoni Krzeski
    Academic press:
    European Archives of Oto-Rhino-Laryngology (rok: 2018, tom: 275, strony: 1845–1851), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00405-018-4996-2 - link to the publication
  3. Small Extracellular Vesicles from Head and Neck Squamous Cell Carcinoma Cells Carry a Proteomic Signature for Tumor Hypoxia
    Authors:
    Głuszko,A.;Szczepan ́ski, M.J.; Whiteside, T.L.; Reichert, T.E.; Siewiera, J.; Ludwig, N.
    Academic press:
    Cancers (rok: 2021, tom: 13, strony: 45307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  4. TGFβ carrying exosomes in plasma: potential biomarkers of cancer progression in patients with head and neck squamous cell carcinoma
    Authors:
    Ludwig N, Yerneni SS, Harasymczuk M, Szczepański MJ, Głuszko A, Kukwa W, Jordan T, Spanier G, Taxis J, Spoerl S, Meier JK, Hinck CS, Campbell PG, Reichert TE, Hinck AP, Whiteside TL.
    Academic press:
    British Journal of Cancer (rok: 2023, tom: 28(9), strony: 1733-1741.), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41416-023-02184-3 - link to the publication
  5. Assessment of cancer stem cell marker expression in primary head and neck squamous cell carcinoma shows prognostic value for aldehyde dehydrogenase (ALDH1A1)
    Authors:
    Tomasz Szafarowski, Janusz Sierdziński, Nils Ludwig, Alicja Głuszko, Anna Filipowska, Mirosław J. Szczepański
    Academic press:
    European Journal of Pharmacology (rok: 2020, tom: 867, strony: 172837), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2019.172837 - link to the publication
  6. TGFβ+ small extracellular vesicles from head and neck squamous cell carcinoma cells reprogram macrophages towards a pro-angiogenic phenotype
    Authors:
    Kärmer T, Kallinger I, Schulz D, Bauer RJ, Spanier G, Spoerl S, Meier JK, Ettl T, Razzo BM, Reichert TE, Hinck AP, Whiteside TL.
    Academic press:
    J Extracell Vesicles. (rok: 2022, tom: 11(12), strony: e12294), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jev2.12294 - link to the publication
  7. Tumor gene signatures that correlate with release of extracellular vesicles shape the immune landscape in head and neck squamous cell carcinoma
    Authors:
    Kallinger I, Rubenich DS, Głuszko A, Kulkarni A, Spanier G, Spoerl S, Taxis J, Poeck H, Szczepański MJ, Ettl T, Reichert TE, Meier JK, Braganhol E, Ferris RL, Whiteside TL, Ludwig N.
    Academic press:
    Clin Exp Immunol (rok: 2023, tom: Feb 8:uxad019, strony: 10.1093/cei/uxad01), Wydawca: Wiley-Oxford University Press
    Status:
    Published
    DOI:
    10.1093/cei/uxad01 - link to the publication
  8. Potential Roles of Tumor Cell- and Stroma Cell-Derived Small Extracellular Vesicles in Promoting a Pro-Angiogenic Tumor Microenvironment
    Authors:
    Nils Ludwig, Dominique S Rubenich, Łukasz Zaręba, Jacek Siewiera, Josquin Pieper, Elizandra Braganhol, Torsten E Reichert, Mirosław J Szczepański
    Academic press:
    Cancers (rok: 2020, tom: 12, strony: 3599), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12123599 - link to the publication
  9. Exosomes in Cancer: Circulating Immune-Related Biomarkers
    Authors:
    Głuszko A, Szczepański MJ, Ludwig N, Mirza SM, Olejarz W.
    Academic press:
    BioMed Research International (rok: 2019, tom: 1628029, strony: 45300), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/1628029 - link to the publication
  10. Small extracellular vesicle-mediated bidirectional crosstalk between neutrophils and tumor cells
    Authors:
    Dominique S. Rubenicha, Nata ́lia Omizzolloa,Mirosław J. Szczepan ́ski, Torsten E. Reichert, Theresa L. Whitesidee, Nils Ludwig, Elizandra Braganhol
    Academic press:
    Cytokine and Growth Factor Reviews (rok: 2021, tom: 61, strony: 16-26), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cytogfr.2021.08.002 - link to the publication

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