Projects funded by the NCN
Multi-onco-map: a multi-omic map of the major driver oncogene function in cancer
2017/26/E/NZ5/00663
Keywords:
cancer mutant p53 K-Ras C-Myc proteomics transcriptomics organoids drug repositioning
Descriptors:
- NZ5_3:
- NZ2_3:
- NZ2_9:
Panel:
NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution :
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 8
Call: SONATA BIS 7 - announced on 2017-06-14
Amount awarded: 1 992 400 PLN
Project start date (Y-m-d): 2018-06-04
Project end date (Y-m-d): 2023-06-03
Project duration:: 60 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- A Driver NeverWorks Alone—Interplay Networks of Mutant p53, MYC, RAS, and Other Universal Oncogenic Drivers in Human CancerAuthors:Maria Grześ, Magdalena Oroń, Zuzanna Staszczak, Akanksha Jaiswar, Magdalena Nowak-Niezgoda, Dawid Walerych *Academic press:Cancers (rok: 2020, tom: 12, strony: 1532-1564), Wydawca: MDPIStatus:PublishedDOI:10.3390/cancers12061532 - link to the publication
- A common druggable signature of oncogenic c-1 Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancerAuthors:Maria Grześ, Akanksha Jaiswar, Marcin Grochowski, Weronika Wojtyś, Wojciech Kaźmierczak, Tomasz Olesiński, Małgorzata Lenarcik, Magdalena Nowak-Niezgoda, Małgorzata Kołos, Giulia Canarutto, Silvano Piazza, Jacek R. Wiśniewski Dawid WalerychStatus:Accepted for publication