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Regulation of epithelial to mesenchymal transition and therapy resistance to antitumor therapies by MCPIP1

2017/26/E/NZ5/00691

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ5_7: Leczenie chorób człowieka
  • NZ3_14: Inne zagadnienia pokrewne

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Katarzyna Miękus

Number of co-investigators in the project: 9

Call

SONATA BIS 7 – announced on 2017-06-14

Amount awarded
2 700 100 PLN
Project start date
2018-05-17
Project end date
2025-05-16
Project duration
84 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (6)

  1. Fatty Acids and a High-Fat Diet Induce Epithelial–Mesenchymal Transition by Activating TGFβ and β-Catenin in Liver Cells

    Authors:
    Oliwia Kwapisz , Judyta Górka , Agata Korlatowicz , Jerzy Kotlinowski , Agnieszka 21121 Waligórska , Paulina Marona , Natalia Pydyn , Jurek W. Dobrucki , Jolanta Jura , Katarzyna Miekus
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 1272), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22031272 – link to the publication

  2. Activity of MCPIP1 RNase in tumor associated processes

    Authors:
    Katarzyna Miekus, Jerzy Kotlinowski, Agata Lichawska-Cieslar, Janusz Rys, Jolanta Jura
    Academic press:
    Journal of Experimental&Clinical Cancer Research (year: 2019, volume: 38, pages: 1-11, artykuł nr 421), Publisher: BMC
    Status:
    Published
    DOI:
    10.1186/s13046-019-1430-6. – link to the publication

  3. MCPIP1 inhibits Wnt/beta-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs

    Authors:
    Judyta Gorka, Paulina Marona, Oliwia Kwapisz, Agnieszka Waligórska, Ewelina Pospiech, Jurek W Dobrucki, Janusz Rys, Jolanta Jura, Katarzyna Miekus
    Academic press:
    Oncogene (year: 2021, volume: 40, pages: 6720-6735), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41388-021-02062-3. – link to the publication

  4. Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation.

    Authors:
    Marona P, Górka J, Kwapisz O, Jura J, Rys J, Hoffman RM, Miekus K.
    Academic press:
    Cell Death Dis (year: 2022, volume: 13(9):814, pages: 814), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41419-022-05251-4. – link to the publication

  5. MCPIP1 regulates focal adhesion kinase and Rho GTPase-dependent migration in clear cell renal cell carcinoma

    Authors:
    Judyta Gorka, Paulina Marona, Oliwia Kwapisz, Janusz Rys, Jolanta Jura, Katarzyna Miekus
    Academic press:
    European Journal of Pharmacology (year: 2022, volume: May 5;922:174804., pages: 174804), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2022.174804 – link to the publication

  6. C-Met as a Key Factor Responsible for Sustaining Undifferentiated Phenotype and Therapy Resistance in Renal Carcinomas

    Authors:
    Paulina Marona, Judyta Górka, Jerzy Kotlinowski, Marcin Majka, Jolanta Jura, Katarzyna Miekus
    Academic press:
    Cells (year: 2019, volume: 8, pages: nr artykułu 272), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8030272 – link to the publication

Articles in post-conference publications (7)

  1. The MCPIP1 protein – a key protector against neoplastic transformation

    Authors:
    P. Marona, O. Kwapisz, I. Piasecka, J. Górka, J. Jura, K. Miekus
    Conference:
    48 FEBS Congress (year: 2024, pages: P-27-084), Publisher: FEBS Open WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Date:
    conference 29.06 – 3.07
    Status:
    Published

  2. The significance of the MCPIP1 level during acquiring resistance to sorafenib in hepatocellular carcinoma

    Authors:
    P. Marona, E. Gonzales Sanchez, I. Fabregat, E. Bertran, J. Vaquero, J. Jura, K. Miękus K
    Conference:
    47th FEBS Congress (year: 2023, pages: 94), Publisher: FEBS Open WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Date:
    conference 08-12.07
    Status:
    Published

  3. Role of c-Met receptor and MCPIP1 in tumor resistance to RTKs

    Authors:
    Marona, P; Gorka, J; Jura; Miekus, K
    Conference:
    FEBS (year: 2019, pages: Volume: 9 Pages: 326-326), Publisher: FEBS Open BIO, WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Date:
    conference 7,2019
    Status:
    Published

  4. Induction of epithelial-mesenchymal transition in liver of mice fed high-fat diet

    Authors:
    Glabica, O; Kotlinowski, J (Kotlinowski, J; Pydyn, N; Jura, J; Miekus, K
    Conference:
    FEBS Congress (year: 2019, pages: Volume: 9 Pages: 349-350), Publisher: FEBS Open WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Date:
    conference 6-11.07.2019
    Status:
    Published

  5. Mechanisms of resistance to antitumor therapy in the treatment of clear cell renal cell carcinoma

    Authors:
    Paulina Marona, Judyta Górka, Jolanta Jura, Katarzyna Miękus
    Conference:
    53 Zjazd PTHC (year: 2019, pages: O30), Publisher: Polish Society for Histochemistry and Cytochemistry
    Date:
    conference 15-18.09.2019
    Status:
    Published

  6. MCPIP1 protein, gender and hepatocellularcarcinoma–what is the relationship between them?

    Authors:
    Oliwia Kwapisz, Paulina Marona, Maciej Głuc, Judyta Górka, Jerzy Kotlinowski, Ewelina Pośpiech, Jolanta Jura, Katarzyna Miękus
    Conference:
    FEBS Congress (year: 2023, pages: 38), Publisher: FEBS Open WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Date:
    conference 8-12.07
    Status:
    Published

  7. MCPIP1 endoribonuclease protects from liver fibrosis and regulates hepatocellular development

    Authors:
    Katarzyna Miekus; Oliwia Kwapisz; Paulina Marona; Judyta Gorka; Jerzy Kotlinowski; Ewelina Pospiech; Jolanta Jura
    Conference:
    AACR Annual Meeting 2024 (year: 2024, pages: 3016), Publisher: Cancer Res (2024) 84 (6_Supplement): 3016.
    Date:
    conference 5.04-10.04.2024
    Status:
    Published

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