Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Regulation of epithelial to mesenchymal transition and therapy resistance to antitumor therapies by MCPIP1

2017/26/E/NZ5/00691

Keywords:

MCPIP1 tumorigenesis EMT therapy resistance

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment
  • NZ3_14: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Miękus 

Number of co-investigators in the project: 9

Call: SONATA BIS 7 - announced on 2017-06-14

Amount awarded: 2 700 100 PLN

Project start date (Y-m-d): 2018-05-17

Project end date (Y-m-d): 2025-05-16

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (5)
  1. MCPIP1 regulates focal adhesion kinase and Rho GTPase-dependent migration in clear cell renal cell carcinoma
    Authors:
    Judyta Gorka, Paulina Marona, Oliwia Kwapisz, Janusz Rys, Jolanta Jura, Katarzyna Miekus
    Academic press:
    European Journal of Pharmacology (rok: 2022, tom: May 5;922:174804., strony: 174804), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2022.174804 - link to the publication
  2. Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation.
    Authors:
    Marona P, Górka J, Kwapisz O, Jura J, Rys J, Hoffman RM, Miekus K.
    Academic press:
    Cell Death Dis (rok: 2022, tom: 13(9):814, strony: 814), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41419-022-05251-4. - link to the publication
  3. Fatty Acids and a High-Fat Diet Induce Epithelial–Mesenchymal Transition by Activating TGFβ and β-Catenin in Liver Cells
    Authors:
    Oliwia Kwapisz , Judyta Górka , Agata Korlatowicz , Jerzy Kotlinowski , Agnieszka 21121 Waligórska , Paulina Marona , Natalia Pydyn , Jurek W. Dobrucki , Jolanta Jura , Katarzyna Miekus
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 1272), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22031272 - link to the publication
  4. MCPIP1 inhibits Wnt/beta-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs
    Authors:
    Judyta Gorka, Paulina Marona, Oliwia Kwapisz, Agnieszka Waligórska, Ewelina Pospiech, Jurek W Dobrucki, Janusz Rys, Jolanta Jura, Katarzyna Miekus
    Academic press:
    Oncogene (rok: 2021, tom: 40, strony: 6720-6735), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41388-021-02062-3. - link to the publication
  5. Activity of MCPIP1 RNase in tumor associated processes
    Authors:
    Katarzyna Miekus, Jerzy Kotlinowski, Agata Lichawska-Cieslar, Janusz Rys, Jolanta Jura
    Academic press:
    Journal of Experimental&Clinical Cancer Research (rok: 2019, tom: 38, strony: 1-11, artykuł nr 421), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s13046-019-1430-6. - link to the publication
  6. New therapeutic strategies in nonalcoholic fatty liver disease: a focus on promising drugs for nonalcoholic steatohepatitis
    Authors:
    Natalia Pydyn, Katarzyna Miękus, Jolanta Jura, Jerzy Kotlinowski
    Academic press:
    Pharmacological Reports (rok: 2019, tom: 72, strony: 1–12), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-019-00020-1 - link to the publication
  7. C-Met as a Key Factor Responsible for Sustaining Undifferentiated Phenotype and Therapy Resistance in Renal Carcinomas
    Authors:
    Paulina Marona, Judyta Górka, Jerzy Kotlinowski, Marcin Majka, Jolanta Jura, Katarzyna Miekus
    Academic press:
    Cells (rok: 2019, tom: 8, strony: nr artykułu 272), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8030272 - link to the publication
  1. Role of c-Met receptor and MCPIP1 in tumor resistance to RTKs
    Authors:
    Marona, P; Gorka, J; Jura; Miekus, K
    Conference:
    FEBS (rok: 2019, ), Wydawca: FEBS Open BIO, WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Data:
    konferencja 7,2019
    Status:
    Published
  2. Mechanisms of resistance to antitumor therapy in the treatment of clear cell renal cell carcinoma
    Authors:
    Paulina Marona, Judyta Górka, Jolanta Jura, Katarzyna Miękus
    Conference:
    53 Zjazd PTHC (rok: 2019, ), Wydawca: Polish Society for Histochemistry and Cytochemistry
    Data:
    konferencja 15-18.09.2019
    Status:
    Published
  3. The significance of the MCPIP1 level during acquiring resistance to sorafenib in hepatocellular carcinoma
    Authors:
    P. Marona, E. Gonzales Sanchez, I. Fabregat, E. Bertran, J. Vaquero, J. Jura, K. Miękus K
    Conference:
    47th FEBS Congress (rok: 2023, ), Wydawca: FEBS Open WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Data:
    konferencja 08-12.07
    Status:
    Published
  4. Induction of epithelial-mesenchymal transition in liver of mice fed high-fat diet
    Authors:
    Glabica, O; Kotlinowski, J (Kotlinowski, J; Pydyn, N; Jura, J; Miekus, K
    Conference:
    FEBS Congress (rok: 2019, ), Wydawca: FEBS Open WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Data:
    konferencja 6-11.07.2019
    Status:
    Published
  5. MCPIP1 protein, gender and hepatocellularcarcinoma–what is the relationship between them?
    Authors:
    Oliwia Kwapisz, Paulina Marona, Maciej Głuc, Judyta Górka, Jerzy Kotlinowski, Ewelina Pośpiech, Jolanta Jura, Katarzyna Miękus
    Conference:
    FEBS Congress (rok: 2023, ), Wydawca: FEBS Open WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Data:
    konferencja 8-12.07
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy