Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Regulation of epithelial to mesenchymal transition and therapy resistance to antitumor therapies by MCPIP1

2017/26/E/NZ5/00691

Keywords:

MCPIP1 tumorigenesis EMT therapy resistance

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment
  • NZ3_14: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Miękus 

Number of co-investigators in the project: 9

Call: SONATA BIS 7 - announced on 2017-06-14

Amount awarded: 2 700 100 PLN

Project start date (Y-m-d): 2018-05-17

Project end date (Y-m-d): 2025-05-16

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (5)
  1. Activity of MCPIP1 RNase in tumor associated processes
    Authors:
    Katarzyna Miekus, Jerzy Kotlinowski, Agata Lichawska-Cieslar, Janusz Rys, Jolanta Jura
    Academic press:
    Journal of Experimental&Clinical Cancer Research (rok: 2019, tom: 38, strony: 1-11, artykuł nr 421), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s13046-019-1430-6. - link to the publication
  2. MCPIP1 inhibits Wnt/beta-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs
    Authors:
    Judyta Gorka, Paulina Marona, Oliwia Kwapisz, Agnieszka Waligórska, Ewelina Pospiech, Jurek W Dobrucki, Janusz Rys, Jolanta Jura, Katarzyna Miekus
    Academic press:
    Oncogene (rok: 2021, tom: 40, strony: 6720-6735), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41388-021-02062-3. - link to the publication
  3. Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation.
    Authors:
    Marona P, Górka J, Kwapisz O, Jura J, Rys J, Hoffman RM, Miekus K.
    Academic press:
    Cell Death Dis (rok: 2022, tom: 13(9):814, strony: 814), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41419-022-05251-4. - link to the publication
  4. New therapeutic strategies in nonalcoholic fatty liver disease: a focus on promising drugs for nonalcoholic steatohepatitis
    Authors:
    Natalia Pydyn, Katarzyna Miękus, Jolanta Jura, Jerzy Kotlinowski
    Academic press:
    Pharmacological Reports (rok: 2019, tom: 72, strony: 1–12), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-019-00020-1 - link to the publication
  5. C-Met as a Key Factor Responsible for Sustaining Undifferentiated Phenotype and Therapy Resistance in Renal Carcinomas
    Authors:
    Paulina Marona, Judyta Górka, Jerzy Kotlinowski, Marcin Majka, Jolanta Jura, Katarzyna Miekus
    Academic press:
    Cells (rok: 2019, tom: 8, strony: nr artykułu 272), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8030272 - link to the publication
  6. Fatty Acids and a High-Fat Diet Induce Epithelial–Mesenchymal Transition by Activating TGFβ and β-Catenin in Liver Cells
    Authors:
    Oliwia Kwapisz , Judyta Górka , Agata Korlatowicz , Jerzy Kotlinowski , Agnieszka 21121 Waligórska , Paulina Marona , Natalia Pydyn , Jurek W. Dobrucki , Jolanta Jura , Katarzyna Miekus
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 1272), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22031272 - link to the publication
  7. MCPIP1 regulates focal adhesion kinase and Rho GTPase-dependent migration in clear cell renal cell carcinoma
    Authors:
    Judyta Gorka, Paulina Marona, Oliwia Kwapisz, Janusz Rys, Jolanta Jura, Katarzyna Miekus
    Academic press:
    European Journal of Pharmacology (rok: 2022, tom: May 5;922:174804., strony: 174804), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2022.174804 - link to the publication
  1. MCPIP1 protein, gender and hepatocellularcarcinoma–what is the relationship between them?
    Authors:
    Oliwia Kwapisz, Paulina Marona, Maciej Głuc, Judyta Górka, Jerzy Kotlinowski, Ewelina Pośpiech, Jolanta Jura, Katarzyna Miękus
    Conference:
    FEBS Congress (rok: 2023, ), Wydawca: FEBS Open WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Data:
    konferencja 8-12.07
    Status:
    Published
  2. Induction of epithelial-mesenchymal transition in liver of mice fed high-fat diet
    Authors:
    Glabica, O; Kotlinowski, J (Kotlinowski, J; Pydyn, N; Jura, J; Miekus, K
    Conference:
    FEBS Congress (rok: 2019, ), Wydawca: FEBS Open WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Data:
    konferencja 6-11.07.2019
    Status:
    Published
  3. The significance of the MCPIP1 level during acquiring resistance to sorafenib in hepatocellular carcinoma
    Authors:
    P. Marona, E. Gonzales Sanchez, I. Fabregat, E. Bertran, J. Vaquero, J. Jura, K. Miękus K
    Conference:
    47th FEBS Congress (rok: 2023, ), Wydawca: FEBS Open WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Data:
    konferencja 08-12.07
    Status:
    Published
  4. Mechanisms of resistance to antitumor therapy in the treatment of clear cell renal cell carcinoma
    Authors:
    Paulina Marona, Judyta Górka, Jolanta Jura, Katarzyna Miękus
    Conference:
    53 Zjazd PTHC (rok: 2019, ), Wydawca: Polish Society for Histochemistry and Cytochemistry
    Data:
    konferencja 15-18.09.2019
    Status:
    Published
  5. Role of c-Met receptor and MCPIP1 in tumor resistance to RTKs
    Authors:
    Marona, P; Gorka, J; Jura; Miekus, K
    Conference:
    FEBS (rok: 2019, ), Wydawca: FEBS Open BIO, WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Data:
    konferencja 7,2019
    Status:
    Published

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