Projects funded by the NCN
The influence of mitochondria-derived hydrogen sulfide (H2S) on the reprogramming of macrophages in atherosclerosis and non-alcoholic fatty liver disease
2017/26/D/NZ4/00480
Keywords:
macrophage polarization hydrogen sulfide mitochondria atherosclerosis non-alcoholic fatty liver disease
Descriptors:
- NZ2_3:
- NZ7_14:
- NZ4_11:
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: SONATA 13 - announced on 2017-06-14
Amount awarded: 1 178 400 PLN
Project start date (Y-m-d): 2018-04-10
Project end date (Y-m-d): 2023-04-09
Project duration:: 60 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (5)
- Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotypeAuthors:Aneta Stachowicz, Rakhi Pandey, Niveda Sundararaman, Vidya Venkatraman, Jennifer E Van Eyk, Justyna Fert-BoberAcademic press:Journal of Inflammation (rok: 2022, tom: 19, strony: 20), Wydawca: BMCStatus:PublishedDOI:10.1186/s12950-022-00317-8 - link to the publication
- The antiatherosclerotic action of 1G244 - An inhibitor of dipeptidyl peptidases 8/9 - is mediated by the induction of macrophage deathAuthors:Anna Wiśniewska, Klaudia Czepiel, Aneta Stachowicz, Bartosz Pomierny, Katarzyna Kuś, Anna Kiepura, Kamila Stachyra, Marcin Surmiak, Józef Madej, Rafał Olszanecki, Maciej SuskiAcademic press:European Journal of Pharmacology (rok: 2023, tom: 944, strony: 175566), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ejphar.2023.175566 - link to the publication
- Diminazene Aceturate Stabilizes Atherosclerotic Plaque and Attenuates Hepatic Steatosis in apoE-Knockout Mice by Influencing Macrophages Polarization and Taurine BiosynthesisAuthors:Aneta Stachowicz, Anna Wiśniewska, Katarzyna Kuś, Magdalena Białas, Magdalena Łomnicka, Justyna Totoń-Żurańska, Anna Kiepura, Kamila Stachyra, Maciej Suski, Beata Bujak-Giżycka, Jacek Jawień, Rafał OlszaneckiiAcademic press:International Journal of Molecular Sciences (rok: 2021, tom: 22(11), strony: 5861), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms22115861 - link to the publication
- Mitochondria-targeted hydrogen sulfide donor reduces atherogenesis by changing macrophage phenotypes and increasing UCP1 expression in vascular smooth muscle cellsAuthors:Aneta Stachowicz, Anna Wiśniewska, Klaudia Czepiel, Bartosz Pomierny, Alicja Skórkowska, Beata Kuśnierz-Cabala, Marcin Surmiak, Katarzyna Kuś, Mark E Wood, Roberta Torregrossa, Matthew Whiteman, Rafał OlszaneckiAcademic press:Biomedicine & Pharmacotherapy (rok: 2024, tom: 180, strony: 117527), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.biopha.2024.117527 - link to the publication
- Mitochondria-targeted hydrogen sulfide donor reduces fatty liver and obesity in mice fed a high fat diet by inhibiting de novo lipogenesis and inflammation via mTOR/SREBP-1 and NF-κB signaling pathwaysAuthors:Aneta Stachowicz, Klaudia Czepiel, Anna Wiśniewska, Kamila Stachyra, Magdalena Ulatowska-Białas, Beata Kuśnierz-Cabala, Marcin Surmiak, Grzegorz Majka, Katarzyna Kuś, Mark E Wood, Roberta Torregrossa, Matthew Whiteman, Rafał OlszaneckiAcademic press:Pharmacological Research (rok: 2024, tom: 209, strony: 107428), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.phrs.2024.107428 - link to the publication