Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanism of the regulation of TNF-alpha-induced MMP9 gene expression by CDKN1A and its role in invasiveness and metastasis in ESCC.

2017/25/B/NZ5/01251

Keywords:

CDKN1A MMP9 TNF-alpha microenvironment esophageal squamous cell carcinoma

Descriptors:

  • NZ3_1: Cell biology
  • NZ5_9: Other related subjects
  • NZ6_8: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Augoff 

Number of co-investigators in the project: 2

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 732 360 PLN

Project start date (Y-m-d): 2018-01-26

Project end date (Y-m-d): 2022-01-25

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Łaźnia wodna z cyrkulacją (9 000 PLN)
  2. Laboratoryjny system oczyszczania wody produkujący wodę oczyszczoną klasy I (8 500 PLN)
  3. komputer wraz z monitorem do obsługi kamery mikroskopowej.
  4. Mikroskop do prowadzenia obserwacji w polu jasnym w świetle przechodzącym (z portem kamery do obrazowania cyfrowego oraz z mozliwoscią rozbudowy o kontrast fazowy, fluorescencję, prostą polaryzację i pole ciemne) wraz z kamera mikroskopowa z dedykowanym oprogramowaniem. (22 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. A novel regulatory function of CDKN1A/p21 in TNFα-induced matrix metalloproteinase 9-dependent migration and invasion of triple-negative breast cancer cells
    Authors:
    Magdalena Zaremba-Czogalla, Anita Hryniewicz-Jankowska, Renata Tabola, Miroslaw Nienartowicz, Kamilla Stach, Jaroslaw Wierzbicki,RobertoCirocchi,PiotrZiolkowski,SabinaTabaczar, Katarzyna Augoff
    Academic press:
    Cellular Signalling (rok: 2018, tom: 47, strony: 27-36), Wydawca: elsevier
    Status:
    Published
    DOI:
    10.1016/j.cellsig.2018.03.010 - link to the publication
  2. The Effect of Neddylation Inhibition on Inflammation-Induced MMP9 Gene Expression in Esophageal Squamous Cell Carcinoma
    Authors:
    Anita Hryniewicz-Jankowska, Jaroslaw Wierzbicki, Renata Tabola, Kamilla Stach, Khalid Sossey-Alaoui, Katarzyna Augoff
    Academic press:
    International Journal of Molecular Scienses (rok: 2021, tom: 22(4), strony: 1716), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22041716 - link to the publication
  3. MMP9: a tough target for targeted therapy for cancer
    Authors:
    Katarzyna Augoff, Anita Hryniewicz-Jankowska, Renata Tabola, Kamilla Stach
    Academic press:
    Cancers , Wydawca: MDPI
    Status:
    Submitted
  4. Invadopodia: clearing the way for cancer cell invasion
    Authors:
    Katarzyna Augoff, Anita Hryniewicz-Jankowska, Renata Tabola
    Academic press:
    Annals of Translational Medicine (rok: 2020, tom: 8(14), strony: 902), Wydawca: AME Publishing Company
    Status:
    Published
    DOI:
    10.21037/atm.2020.02.157 - link to the publication