Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of interaction between P1 purine receptors and nitric oxide bioavailability on intrarenal blood circulation and renal excretion during development in diabetes, in animal model.

2017/25/B/NZ5/01292

Keywords:

diabetes kidney blood flow kidney medulla P1 receptors tissue NO renal excretion,

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_9: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Leszek Dobrowolski 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 573 400 PLN

Project start date (Y-m-d): 2018-01-30

Project end date (Y-m-d): 2022-01-29

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. fotometr płomieniowy (40 000 PLN)
  2. zestaw do kontroli i utrzymywania stabilnej temperatury ciała podczas eksperymentów (6 730 PLN)
  3. Miernik amperometryczny do pomiaru poziomu NO i wolnych rodników (55 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Nonselective and A2a-Selective Inhibition of Adenosine Receptors Modulates Renal Perfusion and Excretion Depending on the Duration of Streptozotocin-Induced Diabetes in Rats
    Authors:
    Joanna Dorota Sitek, Marta Kuczeriszka, Agnieszka Walkowska, Elżbieta Kompanowska-Jezierska, Leszek Dobrowolski
    Academic press:
    Pharmaceuticals (rok: 2023, tom: 16 (5), strony: 732), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ph16050732 - link to the publication
  2. Minor age difference substantially affects renal function in conscious and anaesthetised rats
    Authors:
    Joanna Dorota Sitek, Agnieszka Walkowska, Marta Kuczeriszka, Leszek Dobrowolski*
    Academic press:
    Animal Science Papers And Reports (rok: 2023, ), Wydawca: Institute Of Genetics And Animal Biotechnology Ot The Polish Academy Of Sciences, Jastrzębiec, Poland
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Interplay of the adenosine system and NO in control of renal haemodynamics and excretion: Comparison of normoglycaemic and streptozotocin diabetic rats
    Authors:
    Marta Kuczeriszka, Joanna Dorota Sitek, Agnieszka Walkowska, Janusz Sadowski, Leszek Dobrowolski
    Academic press:
    Nitric Oxide (rok: 2020, tom: 104-105, strony: 20-28), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.niox.2020.08.003 - link to the publication

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