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Information on the principal investigator and host institution

Information of the project and the call

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Identification of novel oncogenic/tumor suppressive miRNA-mRNA interactions in pathogenesis of pediatric T-cell acute lymphoblastic leukemia (T-ALL)

2017/25/N/NZ2/01132

Keywords:

T-cell acute lymphoblastic leukemia immunoprecipitation miRNA next generation sequencjing mRNA-seq RIP-SEQ functional studies in vitro - inhibition/mimicry of miRNA oncogenes tumor suppressor genes

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Genetyki Człowieka Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Monika Drobna-Śledzińska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 13 - announced on 2017-03-15

Amount awarded: 178 428 PLN

Project start date (Y-m-d): 2018-02-13

Project end date (Y-m-d): 2022-10-12

Project duration:: 56 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Identification of Endogenous Control miRNAs for RT-qPCR in T-Cell Acute Lymphoblastic Leukemia
    Authors:
    Drobna Monika, Szarzyńska-Zawadzka Bronisława, Daca-Roszak Patrycja, Kosmalska Maria, Jaksik Roman, Witt Michał, Dawidowska Małgorzata
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: Czasopismo online, nie prowadzi numeracji stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19102858 - link to the publication
  2. KSR2 is novel candidate oncogene in TAL1-positive T-cell acute lymphoblastic leukemia with potential clinical implications
    Authors:
    Monika Drobna-Śledzińska, Natalia Maćkowska-Maślak, Roman Jaksik, Igor Fijałkowski, Maria Kosmalska, Jakub Czarny, Monika Lejman, Łukasz Sędek, Tomasz Szczepański, Katarzyna Derwich, Michał Witt, Panagiotis Ntziachristos, Małgorzata Dawidowska
    Academic press:
    Leukemia , Wydawca: Springer Nature
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. hsa-miR-20b-5p and hsa-miR-363-3p Affect Expression of PTEN and BIM Tumor Suppressor Genes and Modulate Survival of T-ALL Cells In Vitro
    Authors:
    Drobna Monika, Szarzyńska Bronisława, Jaksik Roman, Sędek Łukasz, Kychmiy Anna, Taghon Tom, Van Vlierberghe Pieter, Szczepański Tomasz, Witt Michał, Dawidowska Małgorzata
    Academic press:
    Cells (rok: 2020, tom: 9, strony: brak (czasopismo online)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9051137 - link to the publication
  4. Multiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 in pediatric T-ALL: Focus on miR-363-3p and promoter methylation
    Authors:
    Drobna-Śledzińska Monika, Maćkowska-Maślak Natalia, Jaksik Roman, Kosmalska Maria, Szarzyńska Bronisława, Lejman Monika, Sędek Łukasz, Szczepański Tomasz, Taghon Tom, van Vlierberghe Pieter, Witt Michał, Dawidowska Małgorzata
    Academic press:
    Genes, Chromosomes and Cancer (rok: 2022, tom: 61, strony: 720-733), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/gcc.23085. - link to the publication
  5. CRISPRi for specific inhibition of miRNA clusters and miRNAs with high sequence homology
    Authors:
    Drobna-Śledzińska Monika, Maćkowska-Maślak Natalia, Jaksik Roman, Dąbek Paulina, Witt Michał, Dawidowska Małgorzata
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: na), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-10336-3 - link to the publication
  6. Comprehensive investigation of miRNome identifies novel candidate miRNA-mRNA interactions implicated in T-cell acute lymphoblastic leukemia
    Authors:
    Dawidowska Małgorzata, Jaksik Roman, Drobna Monika, Szarzyńska-Zawadzka Bronisława, Kosmalska Maria, Sędek Łukasz, Machowska Ludmiła, Lalik Anna, Lejman Monika, Ussowicz Marek, Kałwak Krzysztof, Kowalczyk Jerzy, Szczepański Tomasz, Witt Michał
    Academic press:
    Neoplasia (rok: 2019, tom: 21, strony: 294-310), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neo.2019.01.004 - link to the publication

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