Identification of novel oncogenic/tumor suppressive miRNA-mRNA interactions in pathogenesis of pediatric T-cell acute lymphoblastic leukemia (T-ALL)
2017/25/N/NZ2/01132
Keywords
Descriptors
- NZ2_1: Genetyka molekularna
- NZ2_2: Genomika, transkryptomika i epigenomika
- NZ5_3: Patogeneza chorób człowieka
Panel
NZ2 – Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology
Host institution
Instytut Genetyki Człowieka PAN
Voivodeship: wielkopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 13 – announced on 2017-03-15
- Amount awarded
- 178 428 PLN
- Project start date
- 2018-02-13
- Project end date
- 2022-10-12
- Project duration
- 56 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (5)
-
Identification of Endogenous Control miRNAs for RT-qPCR in T-Cell Acute Lymphoblastic Leukemia
- Authors:
- Drobna Monika, Szarzyńska-Zawadzka Bronisława, Daca-Roszak Patrycja, Kosmalska Maria, Jaksik Roman, Witt Michał, Dawidowska Małgorzata
- Academic press:
- International Journal of Molecular Sciences (year: 2018, volume: 19, pages: Czasopismo online, nie prowadzi numeracji stron), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms19102858 – link to the publication
-
Comprehensive investigation of miRNome identifies novel candidate miRNA-mRNA interactions implicated in T-cell acute lymphoblastic leukemia
- Authors:
- Dawidowska Małgorzata, Jaksik Roman, Drobna Monika, Szarzyńska-Zawadzka Bronisława, Kosmalska Maria, Sędek Łukasz, Machowska Ludmiła, Lalik Anna, Lejman Monika, Ussowicz Marek, Kałwak Krzysztof, Kowalczyk Jerzy, Szczepański Tomasz, Witt Michał
- Academic press:
- Neoplasia (year: 2019, volume: 21, pages: 294-310), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.neo.2019.01.004 – link to the publication
-
CRISPRi for specific inhibition of miRNA clusters and miRNAs with high sequence homology
- Authors:
- Drobna-Śledzińska Monika, Maćkowska-Maślak Natalia, Jaksik Roman, Dąbek Paulina, Witt Michał, Dawidowska Małgorzata
- Academic press:
- Scientific Reports (year: 2022, volume: 12, pages: na), Publisher: Springer Nature
- Status:
- Published
- DOI:
- 10.1038/s41598-022-10336-3 – link to the publication
-
Multiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 in pediatric T-ALL: Focus on miR-363-3p and promoter methylation
- Authors:
- Drobna-Śledzińska Monika, Maćkowska-Maślak Natalia, Jaksik Roman, Kosmalska Maria, Szarzyńska Bronisława, Lejman Monika, Sędek Łukasz, Szczepański Tomasz, Taghon Tom, van Vlierberghe Pieter, Witt Michał, Dawidowska Małgorzata
- Academic press:
- Genes, Chromosomes and Cancer (year: 2022, volume: 61, pages: 720-733), Publisher: Wiley
- Status:
- Published
- DOI:
- 10.1002/gcc.23085. – link to the publication
-
hsa-miR-20b-5p and hsa-miR-363-3p Affect Expression of PTEN and BIM Tumor Suppressor Genes and Modulate Survival of T-ALL Cells In Vitro
- Authors:
- Drobna Monika, Szarzyńska Bronisława, Jaksik Roman, Sędek Łukasz, Kychmiy Anna, Taghon Tom, Van Vlierberghe Pieter, Szczepański Tomasz, Witt Michał, Dawidowska Małgorzata
- Academic press:
- Cells (year: 2020, volume: 9, pages: brak (czasopismo online)), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/cells9051137 – link to the publication