Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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A molecular analysis of the CRNDE gene and an attempt to assess the function and clinical significance of the newly discovered micropeptide encoded by this gene

2016/23/D/NZ5/01453

Keywords:

CRNDE prognostic marker micropeptide lncRNA oncogene

Descriptors:

  • NZ1_1: Molecular biology
  • NZ5_3: Pathogenesis of human diseases
  • NZ2_1: Molecular genetics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Łukasz Szafron 

Number of co-investigators in the project: 5

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 400 000 PLN

Project start date (Y-m-d): 2017-07-18

Project end date (Y-m-d): 2020-07-17

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator z wytrząsaniem (Biogenet ES-20) (12 500 PLN)
  2. Mikroskop odwórcony (20 000 PLN)
  3. Inkubator komórek z kontrolą stężenia CO2 (37 000 PLN)
  4. Pipetor elektriniczny Swiftpet Pro (HTL) (1 000 PLN)
  5. Zamrażarka niskotemperaturowa + mikroskop fluorescencyjny odwrócony.
  6. hemocytometr (1 500 PLN)
  7. komora laminarna (28 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. Multi-faceted analysis showing CRNDE gene, transcripts and the lately confirmed micropeptide as key players in ovarian carcinogenesis
    Authors:
    Anna Balcerak, Laura A. Szafron, Tymon Rubel, Bianka Swiderska, Arkadiusz Bonna, Roksana Iwanicka-Nowicka, Jolanta Kupryjanczyk, Lukasz M. Szafron
    Academic press:
    PLOS Medicine , Wydawca: PLOS
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. PROM1, CXCL8, RUNX1, NAV1 and TP73 genes as independent markers predictive of prognosis or response to treatment in two cohorts of high-grade serous ovarian cancer patients
    Authors:
    Agnieszka Dansonka-Mieszkowska, Laura Aleksandra Szafron, Magdalena Kulesza, Anna Stachurska, Pawel Leszczynski, Agnieszka Tomczyk-Szatkowska, Piotr Sobiczewski, Joanna Parada, Mariusz Kulinczak, Joanna Moes-Sosnowska, Barbara Pienkowska-Grela, Jolanta Kupryjanczyk, Magdalena Chechlinska, Lukasz Michal Szafron
    Academic press:
    PLOS One (rok: 2022, tom: 17, strony: e0271539), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0271539 - link to the publication
  1. The CRNDEP localization and interactions suggest its role in RNA metabolism, response to stress and cellular component organization
    Authors:
    Balcerak, A; Cysewski, D; Rubel, T; Grzybowska, E; Dansonka-Mieszkowska, A; Szafron, L
    Conference:
    43rd FEBS Congress, Biochemistry Forever (rok: 2018, ), Wydawca: WILEY
    Data:
    konferencja 7-12.07.2018
    Status:
    Published
  2. CRNDE is involved in the cell cycle progression, proliferation rate and microtubular cytoskeleton regulation.
    Authors:
    A. Balcerak, D. Cysewski, T. Rubel, E. Grzybowska, A. Dansonka-Mieszkowska, J. Kupryjanczyk, L. Szafron
    Conference:
    ASCB | EMBO 2018 Meeting (rok: 2018, ), Wydawca: Molecular Biology of the Cell
    Data:
    konferencja 08-12.12.2018
    Status:
    Accepted for publication

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