Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The impact of anti-cancer therapies on genetic stability of chondrocytes differentiated from human pluripotent stem cells.

2016/23/N/NZ7/01892

Keywords:

pluripotent stem cells differentiation chondrocytes ionizing radiation chemotherapeutics DNA damage DNA repair apoptosis

Descriptors:

  • NZ7_5: Health services, health care research
  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ewelina Stelcer 

Number of co-investigators in the project: 2

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 149 920 PLN

Project start date (Y-m-d): 2017-10-10

Project end date (Y-m-d): 2020-10-09

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. AppleMacBook+oprogramowanie.
  2. Wytrząsarka kołyskowa (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. Ionizing radiation exposure of stem cell-derived chondrocytes affects their gene and microRNA expression profiles and cytokine production
    Authors:
    Ewelina Stelcer, Katarzyna Kulcenty, Marcin Rucinski, Marta Kruszyna-Mochalska, Agnieszka Skrobala, Agnieszka Sobecka, Karol Jopek, Wiktoria Maria Suchorska
    Academic press:
    Scientific Reports (rok: 2021, tom: 11(1):7481, strony: 45304), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-021-86230-1 - link to the publication
  2. Forced differentiation in vitro leads to stress-induced activation of DNA damage response in hiPSC-derived chondrocyte-like cells
    Authors:
    Stelcer E, Kulcenty K, Rucinski M, Jopek K, Richter M, Trzeciak T, Suchorska WM
    Academic press:
    PLoS One (rok: 2018, tom: 13(6):e198079, strony: 45309), Wydawca: PLoS Journals
    Status:
    Published
    DOI:
    10.1371/journal.pone.0198079 - link to the publication
  3. Chondrocytes differentiated from human induced pluripotent stem cells: Response to ionizing radiation
    Authors:
    Stelcer E, Kulcenty K, Suchorska WM
    Academic press:
    PLoS One (rok: 2018, tom: 13(10):e0205691, strony: 45306), Wydawca: PLoS Journals
    Status:
    Published
    DOI:
    10.1371/journal.pone.0205691 - link to the publication
  1. Unlimited Source Of Chondrocyte-Like Cells: How Far Are We?"
    Authors:
    Stelcer E., Richter M., Trzeciak T., Kulcenty K., Ruciński M., Jopek K., Suchorska W.
    Conference:
    Virtual EFORT Congress (rok: 2020, ), Wydawca: Virtual EFORT Congress
    Data:
    konferencja 28-30 October
    Status:
    Published
  2. The unique DDR mechanisms of human induced pluripotent stem cells (hiPSC)-derived chondrocytesThe unique DDR mechanisms of human induced pluripotent stem cells (hiPSC)-derived chondrocytes
    Authors:
    Stelcer E., Kulcenty K., Suchorska WM.
    Conference:
    ESTRO 38 (rok: 2019, ), Wydawca: Elsevier
    Data:
    konferencja 26-30.04.2019
    Status:
    Published

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