Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Role of FMRP protein in the regulation of BRCA1 translation in leukemia cells.

2016/23/N/NZ3/02232

Keywords:

CML BCR-ABL translation BRCA1 FMRP TIAR stress granules PARP inhibitors

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Magdalena Wołczyk 

Number of co-investigators in the project: 3

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 100 000 PLN

Project start date (Y-m-d): 2017-07-19

Project end date (Y-m-d): 2020-07-18

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (8)
  • Book publications / chapters in book publications (1)
  1. TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment
    Authors:
    Magdalena Wolczyk, Remigiusz Serwa, Agata Kominek, Agata Klejman, Jacek Milek, Marta Chwałek, Laura Turos-Korgul, Agata Charzyńska, Michal Dabrowski, Magdalena Dziembowska, Tomasz Skorski, Katarzyna Piwocka, Paulina Podszywalow-Bartnicka
    Academic press:
    iScience (rok: 2023, tom: Volume 26, issue 4, strony: b.d.), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.isci.2023.106543 - link to the publication
  1. Usage of PARP1 inhibitors to target leukemia cells in bone marrow mimicking conditions
    Authors:
    Paulina Podszywałow-Bartnicka, Silvia Meifrede, Ewa Kozłowska, Bac Viet Le, Magdalena Wołczyk, Margaret Nieborowska-Skorska, Tomasz Skorski, Katarzyna Piwocka
    Conference:
    The DNA damage response in physiology and disease (rok: 2019, ), Wydawca: EMBO
    Data:
    konferencja 07-11.10.2019
    Status:
    Published
  2. Hypoxia-induced response of RNA binding proteins in leukemia cells
    Authors:
    Magdalena Wołczyk, Laura Turos, Marta Jakubik, Zofia Dąbrowska, Katarzyna Piwocka, Paulina Podszywałow-Bartnicka
    Conference:
    RNA 2019 24th Annual Meeting of the RNA Society (rok: 2019, ), Wydawca: RNA Society
    Data:
    konferencja 11-16.06.2019
    Status:
    Published
  3. PARP1 inhibitor effect on CML cells evaluated in human bone stroma microenvironment
    Authors:
    Paulina Podszywałow-Bartnicka, Ewa Kozłowska, Silvia Maifrede, Julian Swatler, Magdalena Wołczyk, Anna Mietelska-Porowska, Margaret Nieborowska-Skorska, Katarzyna Piwocka, Tomasz Skorski
    Conference:
    22nd Annual John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy (rok: 2020, ), Wydawca: ESH (European School of Haematology)
    Data:
    konferencja 01-04.10.2020
    Status:
    Published
  4. Influence of hypoxia on the composition of RNA binding proteins complexes in leukemia cells
    Authors:
    Paulina Podszywałow-Bartnicka, Magdalena Wołczyk, Laura Turos, Marta Jakubik, Zofia Dąbrowska, Katarzyna Piwocka
    Conference:
    RNP network dynamics in development and disease (rok: 2019, ), Wydawca: EMBO
    Data:
    konferencja 29.09-02.10.2019
    Status:
    Published
  5. RBP complexes regulate BRCA1 mRNA translation in mouse and human CML cell lines
    Authors:
    Magdalena Wołczyk, Paulina Podszywałow-Bartnicka, Laura Turos, Katarzyna Piwocka
    Conference:
    RNP network dynamics in development and disease (rok: 2019, ), Wydawca: EMBO
    Data:
    konferencja 29.09-02-10-2019
    Status:
    Published
  6. Response of FXR1P and FXR2P proteins to hypoxia in leukemia cells
    Authors:
    Magdalena Wołczyk, Katarzyna Piwocka, Paulina Podszywałow-Bartnicka
    Conference:
    The Complex Life of RNA (rok: 2018, ), Wydawca: EMBO/EMBL
    Data:
    konferencja 03-06.10.2018
    Status:
    Published
  7. Influence of hypoxia on the RNA binding proteins complexes and translation in leukemia cells
    Authors:
    Magdalena Wołczyk, Marta Jakubik, Laura Turos, Milena Wiech, Zofia Dąbrowska, Katarzyna Piwocka, Paulina Podszywałow-Bartnicka
    Conference:
    RNA 2020 25th Annual Meeting of the RNA Society (rok: 2020, ), Wydawca: RNA Society
    Data:
    konferencja 26-31.05.2020
    Status:
    Published
  8. Regulation of BRCA1 translation by RBPs - differences between mouse and human CML cell lines
    Authors:
    Magdalena Wołczyk, Paulina Podszywałow-Bartnicka, Laura Turos, Katarzyna Piwocka
    Conference:
    The DNA damage response in physiology and disease (rok: 2019, ), Wydawca: EMBO
    Data:
    konferencja 07-11.10.2019
    Status:
    Published
  1. Targeting of post-transcriptional regulation as treatment strategy in acute leukemia
    Authors:
    Paulina Podszywałow-Bartnicka, Magdalena Wołczyk, Katarzyna Piwocka
    Book:
    Acute Leukemias (rok: 2020, tom: Acute Leukemias, strony: b.d.), Wydawca: IntechOpen
    Status:
    Published

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