Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The role of hydrogen sulfide and methane, the gut microbiota-derived metabolites, in the regulation of arterial blood pressure and hypertensions.

2016/22/E/NZ5/00647

Keywords:

hydrogen sulfide methane microbiota arterial blood pressure hypertension

Descriptors:

  • NZ5_1:
  • ST5_23:
  • NZ4_4:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marcin Ufnal 

Number of co-investigators in the project: 5

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 998 600 PLN

Project start date (Y-m-d): 2017-04-11

Project end date (Y-m-d): 2021-04-10

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Sprzęt do rozbudowania systemu telemetrycznego do pomiarów hemodynamicznych, umożliwiający pomiary u 12 szczurów jednocześnie. (50 000 PLN)
  2. Lodówka laboratoryjna (5 000 PLN)
  3. Komputer z drukarką (5 000 PLN)
  4. Sprzęt do krótkotrwałych pomiarów hemodynamicznych u zwierząt laboratoryjnych.

Information in the final report

  • Publication in academic press/journals (11)
  1. Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors
    Authors:
    Ewelina Zaorska, Lenka Tomasova, Dominik Koszelewski, Ryszard Ostaszewski and Marcin Ufnal
    Academic press:
    Biomolecules (rok: 2020, tom: 10, strony: 323), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10020323 - link to the publication
  2. Salivary Hydrogen Sulfide Measured with a New Highly Sensitive Self-Immolative Coumarin-Based Fluorescent Probe.
    Authors:
    Zaorska E, Konop M, Ostaszewski R, Koszelewski D, Ufnal M.
    Academic press:
    Molecules (rok: 2018, tom: 23, strony: pii: E2241), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23092241. - link to the publication
  3. Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors
    Authors:
    Onyszkiewicz M , Gawrys-Kopczynska M , Konopelski Piotr , Aleksandrowicz M , Sawicka A , Koźniewska E , Samborowska E , Ufnal Marcin.
    Academic press:
    Pflugers Archiv-European Journal of Physiology (rok: 2019, tom: 471, strony: 1141-1453), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00424-019-02322-y - link to the publication
  4. Parenteral Na2S, a fast-releasing H2S donor, but not GYY4137, a slow-releasing H2S donor, lowers blood pressure in rats.
    Authors:
    Drapala A, Koszelewski D, Tomasova L, Ostaszewski R, Grman M, Ondrias K, Ufnal M.
    Academic press:
    Acta Biochimica Polonica (rok: 2017, tom: 64, strony: 561-566), Wydawca: Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2017 - link to the publication
  5. Methane, a gut bacteriabacteria-produceproduced gas, does not affect arterial blood pressure in normotensive anaesthetized rats.
    Authors:
    Ewelina Zaorska, Marta Gawryś-Kopczyńska, Ryszard Ostaszewski, Dominik Koszelewski, Marcin Ufnal
    Academic press:
    bioRxiv (rok: 2021, tom: 1, strony: 45661), Wydawca: Cold Spring Harbor Laboratory
    Status:
    Published
    DOI:
    10.1101/2021.03.31.437828 - link to the publication
  6. Evaluation of thioamides, thiolactams and thioureas as hydrogen sulfide (H2S) donors for lowering blood pressure
    Authors:
    Zaorska E , Hutsch Tomasz , Gawryś-Kopczyńska M , Ostaszewski R , Ufnal Marcin , Koszelewski D.
    Academic press:
    Bioorganic Chemistry (rok: 2019, tom: 88, strony: 45668), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2019.102941 - link to the publication
  7. Colonic hydrogen sulfide produces portal hypertension and systemic hypotension in rats.
    Authors:
    Huc T, Jurkowska H, Wróbel M, Jaworska K, Onyszkiewicz M, Ufnal M.
    Academic press:
    Experimental Biology and Medicine (rok: 2018, tom: 243, strony: 96-106), Wydawca: SAGE
    Status:
    Published
    DOI:
    10.1177/1535370217741869. - link to the publication
  8. Evaluation of thionolactones as a new type of hydrogen sulfide (H2S) donors for a blood pressure regulation
    Authors:
    Ewelina Zaorska, Marta Gawrys-Kopczynska, Ryszard Ostaszewski, Marcin Ufnal, Dominik Koszelewski
    Academic press:
    Bioorganic Chemistry (rok: 2021, tom: 108, strony: 104650), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2021.104650 - link to the publication
  9. Valeric acid lowers arterial blood pressure in rats
    Authors:
    Maksymilian Onyszkiewicz, Marta Gawrys-Kopczynska, Maciej Sałagaj, Marta Aleksandrowicz, Aneta Sawicka, Ewa Koźniewska, Emilia Samborowska, Marcin Ufnal
    Academic press:
    European Journal of Pharmacology (rok: 2020, tom: 877, strony: 877:173086), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.173086 - link to the publication
  10. Colonic indole, gut bacteria metabolite of tryptophan, increases portal blood pressure in rats.
    Authors:
    Huc T, Konop M, Onyszkiewicz M, Podsadni P, Szczepańska A, Turło J, Ufnal M.
    Academic press:
    Am J Physiol Regul Integr Comp Physiol. (rok: 2018, tom: 315, strony: R646-R655), Wydawca: American Physiological Society
    Status:
    Published
    DOI:
    10.1152/ajpregu.00111.2018 - link to the publication
  11. Methane, a gut bacteriabacteria-produceproduced gas, does not affect arterial blood pressure in normotensive anaesthetized rats.
    Authors:
    Ewelina Zaorska, Marta Gawryś-Kopczyńska, Ryszard Ostaszewski, Dominik Koszelewski, Marcin Ufnal
    Academic press:
    bioRxiv (rok: 2021, tom: 1, strony: 45661), Wydawca: Cold Spring Harbor Laboratory
    Status:
    Published
    DOI:
    10.1101/2021.03.31.437828 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy