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The role of hydrogen sulfide and methane, the gut microbiota-derived metabolites, in the regulation of arterial blood pressure and hypertensions.

2016/22/E/NZ5/00647

Keywords:

hydrogen sulfide methane microbiota arterial blood pressure hypertension

Descriptors:

  • NZ5_1: Etiology of human diseases
  • ST5_23:
  • NZ4_4: Pathophysiology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marcin Ufnal 

Number of co-investigators in the project: 5

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 998 600 PLN

Project start date (Y-m-d): 2017-04-11

Project end date (Y-m-d): 2021-04-10

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer z drukarką (5 000 PLN)
  2. Lodówka laboratoryjna (5 000 PLN)
  3. Sprzęt do rozbudowania systemu telemetrycznego do pomiarów hemodynamicznych, umożliwiający pomiary u 12 szczurów jednocześnie. (50 000 PLN)
  4. Sprzęt do krótkotrwałych pomiarów hemodynamicznych u zwierząt laboratoryjnych.

Information in the final report

  • Publication in academic press/journals (10)
  1. Colonic hydrogen sulfide produces portal hypertension and systemic hypotension in rats.
    Authors:
    Huc T, Jurkowska H, Wróbel M, Jaworska K, Onyszkiewicz M, Ufnal M.
    Academic press:
    Experimental Biology and Medicine (rok: 2018, tom: 243, strony: 96-106), Wydawca: SAGE
    Status:
    Published
    DOI:
    10.1177/1535370217741869. - link to the publication
  2. Methane, a gut bacteriabacteria-produceproduced gas, does not affect arterial blood pressure in normotensive anaesthetized rats.
    Authors:
    Ewelina Zaorska, Marta Gawryś-Kopczyńska, Ryszard Ostaszewski, Dominik Koszelewski, Marcin Ufnal
    Academic press:
    bioRxiv (rok: 2021, tom: 1, strony: 45295), Wydawca: Cold Spring Harbor Laboratory
    Status:
    Published
    DOI:
    10.1101/2021.03.31.437828 - link to the publication
  3. Parenteral Na2S, a fast-releasing H2S donor, but not GYY4137, a slow-releasing H2S donor, lowers blood pressure in rats.
    Authors:
    Drapala A, Koszelewski D, Tomasova L, Ostaszewski R, Grman M, Ondrias K, Ufnal M.
    Academic press:
    Acta Biochimica Polonica (rok: 2017, tom: 64, strony: 561-566), Wydawca: Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2017 - link to the publication
  4. Valeric acid lowers arterial blood pressure in rats
    Authors:
    Maksymilian Onyszkiewicz, Marta Gawrys-Kopczynska, Maciej Sałagaj, Marta Aleksandrowicz, Aneta Sawicka, Ewa Koźniewska, Emilia Samborowska, Marcin Ufnal
    Academic press:
    European Journal of Pharmacology (rok: 2020, tom: 877, strony: 877:173086), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.173086 - link to the publication
  5. Evaluation of thionolactones as a new type of hydrogen sulfide (H2S) donors for a blood pressure regulation
    Authors:
    Ewelina Zaorska, Marta Gawrys-Kopczynska, Ryszard Ostaszewski, Marcin Ufnal, Dominik Koszelewski
    Academic press:
    Bioorganic Chemistry (rok: 2021, tom: 108, strony: 104650), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2021.104650 - link to the publication
  6. Evaluation of thioamides, thiolactams and thioureas as hydrogen sulfide (H2S) donors for lowering blood pressure
    Authors:
    Zaorska E , Hutsch Tomasz , Gawryś-Kopczyńska M , Ostaszewski R , Ufnal Marcin , Koszelewski D.
    Academic press:
    Bioorganic Chemistry (rok: 2019, tom: 88, strony: 45302), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2019.102941 - link to the publication
  7. Salivary Hydrogen Sulfide Measured with a New Highly Sensitive Self-Immolative Coumarin-Based Fluorescent Probe.
    Authors:
    Zaorska E, Konop M, Ostaszewski R, Koszelewski D, Ufnal M.
    Academic press:
    Molecules (rok: 2018, tom: 23, strony: pii: E2241), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23092241. - link to the publication
  8. Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors
    Authors:
    Onyszkiewicz M , Gawrys-Kopczynska M , Konopelski Piotr , Aleksandrowicz M , Sawicka A , Koźniewska E , Samborowska E , Ufnal Marcin.
    Academic press:
    Pflugers Archiv-European Journal of Physiology (rok: 2019, tom: 471, strony: 1141-1453), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00424-019-02322-y - link to the publication
  9. Colonic indole, gut bacteria metabolite of tryptophan, increases portal blood pressure in rats.
    Authors:
    Huc T, Konop M, Onyszkiewicz M, Podsadni P, Szczepańska A, Turło J, Ufnal M.
    Academic press:
    Am J Physiol Regul Integr Comp Physiol. (rok: 2018, tom: 315, strony: R646-R655), Wydawca: American Physiological Society
    Status:
    Published
    DOI:
    10.1152/ajpregu.00111.2018 - link to the publication
  10. Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors
    Authors:
    Ewelina Zaorska, Lenka Tomasova, Dominik Koszelewski, Ryszard Ostaszewski and Marcin Ufnal
    Academic press:
    Biomolecules (rok: 2020, tom: 10, strony: 323), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10020323 - link to the publication

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