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Information on the principal investigator and host institution

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Resolving structure and functions of RECQL4 and BLM helicases to understand consequences of deleterious genetic alterations in glioma pathogenesis.

2016/22/M/NZ3/00679

Keywords:

RECQL helicase structural studies deleterious mutations binding partners DNA replication and repair glioma pathogenesis,

Descriptors:

  • NZ3_1:
  • NZ3_3:
  • NZ2_2:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Bożena Kamińska-Kaczmarek 

Number of co-investigators in the project: 7

Call: HARMONIA 8 - announced on 2016-06-15

Amount awarded: 1 252 800 PLN

Project start date (Y-m-d): 2017-05-15

Project end date (Y-m-d): 2021-05-14

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. BLM helicase overexpressed in human gliomas contributes to diverse responses of human glioma cells to chemotherapy.
    Authors:
    Wojnicki K, Kaczmarczyk A, Wojtas B, Kaminska B.
    Academic press:
    Cell Death Discovery (rok: 2023, tom: 9, strony: 156-167), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41420-023-01451-9 - link to the publication
  2. Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells.
    Authors:
    Król SK, Kaczmarczyk A, Wojnicki K, Wojtas B, Gielniewski B, Grajkowska W, Kotulska K, Szczylik C, Czepko R, Banach M, Kaspera W, Szopa W, Marchel A, Czernicki T, Kaminska B
    Academic press:
    Cancers (rok: 2020, tom: 12 (10), strony: 2919), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12102919 - link to the publication
  3. Shared and non-overlapping functions of RECQL4 and BLM helicases in chemotherapeutics-induced glioma cell responses
    Authors:
    Kamil Wojnicki, Bartosz Wojtas, Iwona A. Ciechomska, Beata Kaza, Matthew Guille, Waldemar Priebe, Bozena Kaminska
    Status:
    Accepted for publication

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