Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Processing and postrtranslational modifications of ghrelin - an appetite modulating peptide as the mechanistic link between prolonged inflammation, chronic bacterial infection and obesity development.

2016/22/E/NZ5/00332

Keywords:

obesity periodontitis ghrelin appetite regulation Porrphyromonas gingivalis

Descriptors:

  • NZ6_4: Bacteriology
  • NZ1_2: Biochemistry
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Tomasz Kantyka 

Number of co-investigators in the project: 6

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 2 033 860 PLN

Project start date (Y-m-d): 2017-05-08

Project end date (Y-m-d): 2023-05-07

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System HPLC z detektorem fluorescencji (250 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity
    Authors:
    Gruba N, Bielecka E, Wysocka M, Wojtysiak A, Brzezińska-Bodal M, Sychowska K, Kalińska M, Magoch M, Pęcak A, Falkowski K, Wiśniewska M, Sąsiadek L, Płaza K, Kroll E, Pejkovska A, Rehders M, Brix K, Dubin G, Kantyka T, Potempa J, Lesner A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 28;20(7), strony: E1557), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20071557 - link to the publication
  2. Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1
    Authors:
    Milewska, A., Falkowski, K., Kulczycka, M., Bielecka, E., Naskalska, A., Mak, P., Lesner, A., Ochman, M., Urlik, M., Diamandis, E., Prassas, I., Potempa, J., Kantyka, T. and Pyrc, K.
    Academic press:
    Science Signalling (rok: 2020, tom: 13/659, strony: nie dotyczy), Wydawca: American Association for the Advancement of Science
    Status:
    Published
    DOI:
    10.1126/scisignal.aba9902 - link to the publication
  3. Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis
    Authors:
    Falkowski, K., Bielecka, E., Thogersen, I. B., Bochenska, O., Plaza, K., Kalinska, M., Sasiadek, L., Magoch, M., Pecak, A., Wisniewska, M., Gruba, N., Wysocka, M., Wojtysiak, A., Brzezinska-Bodal, M., Sychowska, K., Pejkovska, A., Rehders, M., Butler, G., Overall, C. M., Brix, K., Dubin, G., Lesner, A., Kozik, A., Enghild, J. J., Potempa, J. and Kantyka, T.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21/12, strony: nie dotyczy), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21124383 - link to the publication
  4. Discovery of Novel Potential Reversible Peptidyl Arginine Deiminase Inhibitor
    Authors:
    Aliko A, Kamińska M, Falkowski K, Bielecka E, Benedyk-Machaczka M, Malicki S, Kozieł J, Wong A, Bryzek D, Kantyka T, Mydel P.
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 2;20(9), strony: E2174), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20092174 - link to the publication
  5. Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis
    Authors:
    Jonsson MK, Kantyka T, Falkowski K, Aliko A, Aga AB, Lillegraven S, Sexton J, Fevang BT, Mydel P, Haavardsholm EA.
    Academic press:
    Scandinavian Journal of Rheumatology (rok: 2019, tom: 23, strony: 45300), Wydawca: Taylor&Francis Online
    Status:
    Published
    DOI:
    10.1080/03009742.2019.1641216 - link to the publication
  6. Application of the In Vitro HoxB8 Model System to Characterize the Contributions of Neutrophil-LPS Interaction to Periodontal Disease
    Authors:
    Sochalska, M., Stanczyk, M. B., Uzarowska, M., Zubrzycka, N., Kirschnek, S., Grabiec, A. M., Kantyka, T. and Potempa, J.
    Academic press:
    Pathogens (rok: 2020, tom: 45542, strony: nie dotyczy), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pathogens9070530 - link to the publication

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