Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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RNA structures and interactions with Gag protein that specify Ty1 RNA functions during retrotransposon replication

2016/22/E/NZ3/00426

Keywords:

2D and 3D RNA structure RNA function Ty1 retrotransposon Ty1 Gag

Descriptors:

  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Pachulska-Wieczorek 

Number of co-investigators in the project: 5

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 152 060 PLN

Project start date (Y-m-d): 2017-05-08

Project end date (Y-m-d): 2022-12-07

Project duration:: 67 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System do elektrotransferu (16 000 PLN)
  2. Zestaw komputerowy wraz z oprogramowaniem (Office, Corel, EndNote, PyMol) (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (6)
  1. Na dobre i na złe: rola endogennych retroelementów u człowieka
    Authors:
    Zawadzka M., Pachulska-Wieczorek K.
    Academic press:
    Postępy Biochemii (rok: 2019, tom: 65(3), strony: 217-223), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2019_272 - link to the publication
  2. RNAthor - fast, accurate normalization, visualization and statistical analysis of RNA probing data resolved by capillary electrophoresis
    Authors:
    Gumna J., Zok T., Figurski K., Pachulska-Wieczorek K., Szachniuk M.
    Academic press:
    Plos One (rok: 2020, tom: 15 (10), strony: 01.gru), Wydawca: Plos
    Status:
    Published
    DOI:
    10.1371/journal.pone.0239287 - link to the publication
  3. Cell Compartment-Specific Folding of Ty1 Long Terminal Repeat Retrotransposon RNA Genome
    Authors:
    Zawadzka M, Andrzejewska-Romanowska A, Gumna J, Garfinkel DJ, Pachulska-Wieczorek K.
    Academic press:
    Viruses (rok: 2022, tom: 14(9), strony: 45306), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/v14092007 - link to the publication
  4. Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition
    Authors:
    Kumari, P., Aeschimann, F., Gaidatzis, D., Keusch, J.J., Ghosh, P., Neagu, A., Pachulska-Wieczorek, K., Bujnicki, J.M., Gut, H., Grosshans, Ciosk, R.
    Academic press:
    Nature Communications (rok: 2018, tom: 9, strony: 45306), Wydawca: NATURE PUBLISHING GROUP
    Status:
    Published
    DOI:
    10.1038/s41467-018-03920-7 - link to the publication
  5. On the Way to Understanding the Interplay between the RNA Structure and Functions in Cells: A Genome-Wide Perspective
    Authors:
    Andrzejewska A., Zawadzka M., Pachulska-Wieczorek K.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21(18), strony: 15), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/ijms21186770 - link to the publication
  6. RNA Binding Properties of the Ty1 LTR-Retrotransposon Gag Protein
    Authors:
    Gumna J, Andrzejewska-Romanowska A, Garfinkel DJ, Pachulska-Wieczorek K.
    Academic press:
    Int J Mol Sci (rok: 2021, tom: 22(16), strony: 9103), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22169103 - link to the publication
  7. In vivo structure of the Ty1 retrotransposon RNA genome
    Authors:
    Andrzejewska A., Zawadzka M., Gumna J., Garfinkel D.J., Pachulska-Wieczorek K.
    Academic press:
    Nucleic Acids Research (rok: 2021, tom: 49(5), strony: 2878-2893), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkab090 - link to the publication
  8. Retroviral-like determinants and functions required for dimerization of Ty1 retrotransposon RNA
    Authors:
    Gumna J., Purzycka K. J., Ahn H.W., Garfinkel D.J., Pachulska-Wieczorek K.
    Academic press:
    RNA Biology (rok: 2019, tom: 16(12), strony: 1749-1763), Wydawca: Landes Bioscience
    Status:
    Published
    DOI:
    10.1080/15476286.2019.1657370 - link to the publication
  1. Regulation of LTR-retrotransposons life cycle
    Authors:
    Julita Gumna, Katarzyna J. Purzycka, Agniva Saha, Małgorzata Zawadzka, David Garfinkel, Katarzyna Pachulska-Wieczorek
    Conference:
    BIO 2018 Congress (rok: 2018, ), Wydawca: Polish Biochemical Society & Polish Academy of Sciences
    Data:
    konferencja 18-21.09.2018
    Status:
    Published
    DOI:
    link to the publication
  2. From retrotransposon genome structure to function: Probing the structure of Ty1 genomic RNA in distinct biological states using SHAPE
    Authors:
    Andrzejewska A., Zawadzka M., Gumna J., Garfinkel D.J., Pachulska-Wieczorek K.
    Conference:
    RNA 2019 (rok: 2019, ), Wydawca: RNA Society
    Data:
    konferencja 43627
    Status:
    Published
  3. Determinants of genomic RNA dimerization and packaging in the Saccharomyces cerevisiae LTR-retrotransposon Ty1
    Authors:
    Julita Gumna, Katarzyna J. Purzycka, David J. Garfinkel, Katarzyna Pachulska-Wieczorek
    Conference:
    RNAtion (rok: 2017, ), Wydawca: UAM w Poznaniu
    Data:
    konferencja 18-19.09.2017
    Status:
    Published
  4. Structural determinants of genomic RNA dimerization and packaging in the LTR-retrotransposon Ty1
    Authors:
    Julita Gumna, Katarzyna J. Purzycka, Małgorzata Zawadzka, David Garfinkel, Katarzyna Pachulska-Wieczorek
    Conference:
    BIO 2018 Congress (rok: 2018, ), Wydawca: Polish Biochemical Society & Polish Academy of Sciences
    Data:
    konferencja 18-21.09.2018
    Status:
    Published
    DOI:
    link to the publication
  5. Retrovirus-like transposons genome packaging: Gag function and structural determinants of Ty1 RNA dimerization
    Authors:
    Gumna J., Purzycka K. J., Ahn H.W., Garfinkel D.J., Pachulska-Wieczorek K.
    Conference:
    RNA 2019 (rok: 2019, ), Wydawca: RNA Society
    Data:
    konferencja 43627
    Status:
    Published
  6. Structural determinants of Ty1 genomic RNA dimerization: the role of Gag and p22 restriction factor
    Authors:
    Julita Gumna, Katarzyna J. Purzycka, Agniva Saha, David Garfinkel, Katarzyna Pachulska-Wieczorek
    Conference:
    6th Central European Congress of Life Science Eurobiotech (rok: 2017, ), Wydawca: Targi w Krakowie Ltd.
    Data:
    konferencja 11-14.09.2017
    Status:
    Published
    DOI:
    link to the publication

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