Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanisms of an increased prothrombotic activity of blood platelets in sclerosis multiplex

2016/21/B/NZ4/00543

Keywords:

blood platelets megakaryocytes fibrinogen gene expression miRNA multiple sclerosis

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ4_7: Neurophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

UNIWERSYTET ŁÓDZKI, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Joanna Saluk-Bijak 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 733 430 PLN

Project start date (Y-m-d): 2017-02-06

Project end date (Y-m-d): 2021-02-05

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mały fluorymetr do oznaczeń ilości RNA (9 000 PLN)
  2. Kompaktowa zamrażarka niskotemperaturowa (32 000 PLN)
  3. Szafa chłodnicza (3 000 PLN)
  4. Wirówka z zestawem rotorów (25 000 PLN)
  5. Komora do pracy czystej z próbkami DNA/RNA (13 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. Increased Pro-Thrombotic Platelet Activity Associated with Thrombin/PAR1-Dependent Pathway Disorderin Patients with Secondary ProgressiveMultiple Sclerosis
    Authors:
    Angela Dziedzic, Elzbieta Miller, Michal Bijak, Lukasz Przyslo, Joanna Saluk-Bijak
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 7722), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21207722 - link to the publication
  2. Interactions between platelets and leukocytes in pathogenesis of multiple sclerosis
    Authors:
    Angela Dziedzic, Michał Bijak
    Academic press:
    Advances in Clinical and Experimental Medicine (rok: 2019, tom: 28, strony: 277-285), Wydawca: Wroclaw Medical University
    Status:
    Published
    DOI:
    10.17219/acem/83588 - link to the publication
  3. Pro-Thrombotic Activity of Blood Platelets in Multiple Sclerosis
    Authors:
    Joanna Saluk-Bijak, Angela Dziedzic, Michal Bijak
    Academic press:
    Cells (rok: 2019, tom: 8, strony: 110), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8020110 - link to the publication
  4. Increased level of fibrinogen chains in the proteome of blood platelets in secondary progressive multiple sclerosis patients
    Authors:
    Michal Bijak, Alicja Olejnik, Bozena Rokita, Agnieszka Morel, Angela Dziedzic, Elzbieta Miller, Joanna Saluk‐Bijak
    Academic press:
    Journal of Cellular and Molecular Medicine pub (rok: 2019, tom: 23, strony: 3476–3482), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1111/jcmm.14244 - link to the publication
  5. Oxidative Damage of Blood Platelets Correlates with the Degree of Psychophysical Disability in Secondary Progressive Multiple Sclerosis
    Authors:
    Angela Dziedzic, Agnieszka Morel, Elzbieta Miller, Michal Bijak, Tomasz Sliwinski, Ewelina Synowiec, Michal Ceremuga, Joanna Saluk-Bijak
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2020, tom: 2020, strony: Article ID 2868014), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2020/2868014 - link to the publication
  6. The Molecular Aspects of Disturbed Platelet Activation through ADP/P2Y12 Pathway in Multiple Sclerosis.
    Authors:
    Dziedzic A, Miller E, Saluk-Bijak J, Niwald M, Bijak M.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 6572), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126572 - link to the publication

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