Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New mechanisms of impaired fibrinolysis in type 2 diabetes.

2016/21/N/NZ5/01425

Keywords:

type 2 diabetes fibrinolysis alpha-2- antiplasmin glycation carbonylation aspirin

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Agata Bryk 

Number of co-investigators in the project: 3

Call: PRELUDIUM 11 - announced on 2016-03-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2017-03-22

Project end date (Y-m-d): 2020-03-21

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. -.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (5)
  1. Glycation and acetylation sites on fibrinogen in plasma fibrin clot of patients with type 2 diabetes: Effects of low-dose acetylsalicylic acid.
    Authors:
    Bryk AH, Zettl K, Wiśniewski JR, Undas A.
    Academic press:
    Thrombosis Research (rok: 2021, tom: 198, strony: 93-98), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.thromres.2020.11.031 - link to the publication
  2. Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus: associations with a prothrombotic state and hypofibrinolysis.
    Authors:
    Bryk AH, Prior SM, Plens K, Konieczynska M, Hohendorff J, Malecki MT, Butenas S, Undas A
    Academic press:
    Cardiovascular Diabetology (rok: 2019, tom: 18, strony: 49), Wydawca: BioMed Central Ltd., part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12933-019-0850-0 - link to the publication
  3. Interaction of glycated and acetylated human α2-antiplasmin with fibrin clots.
    Authors:
    Bryk AH, Satała D, Natorska J, Rąpała-Kozik M, Undas A.
    Academic press:
    Blood Coagulation and Fibrinolysis (rok: 2020, tom: 31, strony: 393-396), Wydawca: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/MBC.0000000000000935 - link to the publication
  4. Sex-specific alteration to α2-antiplasmin incorporation in patients with type 2 diabetes.
    Authors:
    Bryk AH, Siudut J, Broniatowska E, Bagoly Z, Baráth B, Katona É, Undas A
    Academic press:
    Thrombosis Research (rok: 2020, tom: 185, strony: 55-62), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.thromres.2019.09.032 - link to the publication
  5. Identification of glycated and acetylated lysine residues in human α2-antiplasmin.
    Authors:
    Bryk AH, Cysewski D, Dadlez M, Undas A
    Academic press:
    Biochemical and Biophysical Research Communications (rok: 2020, tom: 521, strony: 19-23), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2019.09 - link to the publication
  6. Plasma Protein Oxidation as a Determinant of Impaired Fibrinolysis in Type 2 Diabetes.
    Authors:
    Bryk AH, Konieczynska M, Rostoff P, Broniatowska E, Hohendorff J, Malecki MT, Undas A.
    Academic press:
    Thrombosis and Haemostasis (rok: 2019, tom: 119, strony: 213-222), Wydawca: Georg Thieme Verlag KG Stuttgart · New York.
    Status:
    Published
    DOI:
    10.1055/s-0038-1676609 - link to the publication
  1. Protein oxidation and cardiovascular disease in patients with type 2 diabetes
    Authors:
    A H Bryk, M Konieczynska, E Broniatowska, A Undas
    Conference:
    ESC Congress 2018 (rok: 2018, ), Wydawca: European Heart Journal, Volume 39, Issue suppl_1, August 2018, ehy563.P4476, https://doi.org/10.1093/eurheartj/ehy563.P4476
    Data:
    konferencja 25-29.08
    Status:
    Published
  2. Oksydacja białek osocza jako wyznacznik upośledzonej fibrynolizy w cukrzycy typu 2: wpływ choroby sercowo-naczyniowej.
    Authors:
    Agata Hanna Bryk, Małgorzata Konieczyńśka, Paweł Rostoff, Elżbieta Broniatowska
    Conference:
    VI Konferencja Doktorantów Uniwersytetu Jagiellońskiego - Collegium Medicum (rok: 2018, ), Wydawca: Zeszyty Naukowe Towarzystwa Naukowego Doktorantów Uniwersytetu Jagiellońskiego. Wydawnictwo nowa strona
    Data:
    konferencja 19 maja
    Status:
    Published
  3. Gender- specific Alteration in α2- antiplasmin Incorporation in Type 2 Diabetes Mellitus
    Authors:
    A.H. Bryk; J. Siudut; Z. Bagoly; B. Baráth; É. Katona; A. Undas
    Conference:
    XXVII Congress of the International Society on Thrombosis and Haemostasis (rok: 2019, ), Wydawca: Research and Practice in Thrombosis and Heamostasis, Volume 3, Issue S1 Special Issue
    Data:
    konferencja 6-10.07
    Status:
    Published
  4. Identyfikacja glikowanych i acetylowanych reszt lizynowych w ludzkiej alfa-2-antyplazminie
    Authors:
    Agata Bryk, Dominik Cysewski, Michał Dadlez, Anetta Undas
    Conference:
    XXIV Sympozjum Sekcji Towarzystw Kardiologicznego przy udziale Komitetu Nauk Fizjologicznych i Farmakologicznych PAN (rok: 2019, ), Wydawca: Folia Medica Cracoviensa Vol LIX Suppl 1., 2019
    Data:
    konferencja 28-30.11
    Status:
    Published
  5. Predyktory krążących we krwi markerów NETozy w cukrzycy typu 2: związki z stanem prozakrzepowym i hipofibrynolizą
    Authors:
    Agata H. Bryk, Shannon M. Prior, Krzysztof Plens, Małgorzata Konieczynska, Jerzy Hohendorff, Maciej T. Małecki, Saulius Butenas, Anetta Undas
    Conference:
    IX Konferencja Doktorantów Uniwersytetu Jagiellońskiego – Collegium Medicum (rok: 2019, ), Wydawca: Wydawnictwo Przegląd Lekarski 2019 / 76 / Suplement 2
    Data:
    konferencja 1,06
    Status:
    Published