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New mechanisms of impaired fibrinolysis in type 2 diabetes.

2016/21/N/NZ5/01425

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Agata Hanna Bryk

Number of co-investigators in the project: 3

Call

PRELUDIUM 11 – announced on 2016-03-15

Amount awarded
150 000 PLN
Project start date
2017-03-22
Project end date
2020-03-21
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. -.

Information in the final report

Publication in academic press/journals (6)

  1. Identification of glycated and acetylated lysine residues in human α2-antiplasmin.

    Authors:
    Bryk AH, Cysewski D, Dadlez M, Undas A
    Academic press:
    Biochemical and Biophysical Research Communications (year: 2020, volume: 521, pages: 19-23), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2019.09 – link to the publication

  2. Glycation and acetylation sites on fibrinogen in plasma fibrin clot of patients with type 2 diabetes: Effects of low-dose acetylsalicylic acid.

    Authors:
    Bryk AH, Zettl K, Wiśniewski JR, Undas A.
    Academic press:
    Thrombosis Research (year: 2021, volume: 198, pages: 93-98), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.thromres.2020.11.031 – link to the publication

  3. Interaction of glycated and acetylated human α2-antiplasmin with fibrin clots.

    Authors:
    Bryk AH, Satała D, Natorska J, Rąpała-Kozik M, Undas A.
    Academic press:
    Blood Coagulation and Fibrinolysis (year: 2020, volume: 31, pages: 393-396), Publisher: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/MBC.0000000000000935 – link to the publication

  4. Plasma Protein Oxidation as a Determinant of Impaired Fibrinolysis in Type 2 Diabetes.

    Authors:
    Bryk AH, Konieczynska M, Rostoff P, Broniatowska E, Hohendorff J, Malecki MT, Undas A.
    Academic press:
    Thrombosis and Haemostasis (year: 2019, volume: 119, pages: 213-222), Publisher: Georg Thieme Verlag KG Stuttgart · New York.
    Status:
    Published
    DOI:
    10.1055/s-0038-1676609 – link to the publication

  5. Sex-specific alteration to α2-antiplasmin incorporation in patients with type 2 diabetes.

    Authors:
    Bryk AH, Siudut J, Broniatowska E, Bagoly Z, Baráth B, Katona É, Undas A
    Academic press:
    Thrombosis Research (year: 2020, volume: 185, pages: 55-62), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.thromres.2019.09.032 – link to the publication

  6. Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus: associations with a prothrombotic state and hypofibrinolysis.

    Authors:
    Bryk AH, Prior SM, Plens K, Konieczynska M, Hohendorff J, Malecki MT, Butenas S, Undas A
    Academic press:
    Cardiovascular Diabetology (year: 2019, volume: 18, pages: 49), Publisher: BioMed Central Ltd., part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12933-019-0850-0 – link to the publication

Articles in post-conference publications (5)

  1. Identyfikacja glikowanych i acetylowanych reszt lizynowych w ludzkiej alfa-2-antyplazminie

    Authors:
    Agata Bryk, Dominik Cysewski, Michał Dadlez, Anetta Undas
    Conference:
    XXIV Sympozjum Sekcji Towarzystw Kardiologicznego przy udziale Komitetu Nauk Fizjologicznych i Farmakologicznych PAN (year: 2019, pages: 20), Publisher: Folia Medica Cracoviensa Vol LIX Suppl 1., 2019
    Date:
    conference 28-30.11
    Status:
    Published

  2. Predyktory krążących we krwi markerów NETozy w cukrzycy typu 2: związki z stanem prozakrzepowym i hipofibrynolizą

    Authors:
    Agata H. Bryk, Shannon M. Prior, Krzysztof Plens, Małgorzata Konieczynska, Jerzy Hohendorff, Maciej T. Małecki, Saulius Butenas, Anetta Undas
    Conference:
    IX Konferencja Doktorantów Uniwersytetu Jagiellońskiego – Collegium Medicum (year: 2019, pages: 8), Publisher: Wydawnictwo Przegląd Lekarski 2019 / 76 / Suplement 2
    Date:
    conference 1,06
    Status:
    Published

  3. Oksydacja białek osocza jako wyznacznik upośledzonej fibrynolizy w cukrzycy typu 2: wpływ choroby sercowo-naczyniowej.

    Authors:
    Agata Hanna Bryk, Małgorzata Konieczyńśka, Paweł Rostoff, Elżbieta Broniatowska
    Conference:
    VI Konferencja Doktorantów Uniwersytetu Jagiellońskiego - Collegium Medicum (year: 2018, pages: 28), Publisher: Zeszyty Naukowe Towarzystwa Naukowego Doktorantów Uniwersytetu Jagiellońskiego. Wydawnictwo nowa strona
    Date:
    conference 19 maja
    Status:
    Published

  4. Protein oxidation and cardiovascular disease in patients with type 2 diabetes

    Authors:
    A H Bryk, M Konieczynska, E Broniatowska, A Undas
    Conference:
    ESC Congress 2018 (year: 2018, pages: 905), Publisher: European Heart Journal, Volume 39, Issue suppl_1, August 2018, ehy563.P4476, https://doi.org/10.1093/eurheartj/ehy563.P4476
    Date:
    conference 25-29.08
    Status:
    Published

  5. Gender- specific Alteration in α2- antiplasmin Incorporation in Type 2 Diabetes Mellitus

    Authors:
    A.H. Bryk; J. Siudut; Z. Bagoly; B. Baráth; É. Katona; A. Undas
    Conference:
    XXVII Congress of the International Society on Thrombosis and Haemostasis (year: 2019, pages: 239), Publisher: Research and Practice in Thrombosis and Heamostasis, Volume 3, Issue S1 Special Issue
    Date:
    conference 6-10.07
    Status:
    Published

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