Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of selected signaling pathways in zinc deficiency

2015/19/B/NZ4/01890

Keywords:

zinc deficiency depression zinc deficiency ketamine Ro-25-6981 mTOR ERK/CREB

Descriptors:

  • NZ4_7: Neurophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Gabriel Nowak 

Number of co-investigators in the project: 5

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 083 100 PLN

Project start date (Y-m-d): 2016-06-20

Project end date (Y-m-d): 2021-06-19

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Termoblok (3 500 PLN)
  2. System do mikrodializy (40 000 PLN)
  3. Urządzenie do anaestezji zwierząt.
  4. Stalowe matryce do wycinania struktur mózgów (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. Combined hyperforin and lanicemine treatment instead of ketamine or imipramine restores behavioral deficits induced by chronic restraint stress and dietary zinc restriction in mice.
    Authors:
    Pochwat B, Misztak P, Masternak J, Bączyńska E, Bijata K, Roszkowska M, Bijata M, Włodarczyk J, Szafarz M, Wyska E, Muszyńska B, Krakowska A, Opoka W, Nowak G, Szewczyk B.
    Academic press:
    Frontiers in Pharmacology (rok: 2022, tom: 13, strony: id. art. 933364), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fphar.2022.933364 - link to the publication
  2. An update on NMDA antagonists in depression
    Authors:
    Bartłomiej Pochwat, Gabriel Nowak, Bernadeta Szewczyk
    Academic press:
    Expert Revievs of Neurotherapetics (rok: 2019, tom: 11, strony: 1055-1067), Wydawca: Taylor Francis
    Status:
    Published
    DOI:
    10.1080/14737175.2019.1643237 - link to the publication
  3. Ketamine and Ro 25-6981 reverse behavioral abnormalities in rats subjected to dietary zinc restriction
    Authors:
    Bartłomiej Pochwat, Helena Domin, Anna Rafało-Ulińska, Bernadeta Szewczyk, Gabriel Nowak
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21 (13), strony: 4791), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21134791 - link to the publication
  1. NMDA receptor antagonists reverse behavioral disturbances induced by zinc deficiency
    Authors:
    Nowak G., Szewczyk B., Rafało-Ulińska A., Pochwat B
    Conference:
    2-nd International Conference on Pharmaceutical and Medical Sciences (rok: 2018, ), Wydawca: Pharmaceutical Faculty of the Jagiellonian University
    Data:
    konferencja 21-23 wrzesień
    Status:
    Published
  2. Ketamine and Ro 25-6981 reverse behavioral disturbances induced by zinc deficiency
    Authors:
    Pochwat B, Szewczyk B, Nowak G
    Conference:
    CINP 2018 (rok: 2018, ), Wydawca: The International College of Neuropsychopharmacology
    Data:
    konferencja 16-19 czerwiec
    Status:
    Published

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