Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Changes in protein composition and electrophysiological characteristics of glutamatergic synapse in a mouse model of acute hepatic encephalopathy: role of the transforming growth factor β1 (TGF β1).

2015/19/N/NZ5/02249

Keywords:

hepatic encephalopathy azoxymethane synapse TGF-beta1

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_9: Other related subjects
  • NZ4_7: Neurophysiology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Mariusz Popek 

Number of co-investigators in the project: 3

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 149 400 PLN

Project start date (Y-m-d): 2016-07-08

Project end date (Y-m-d): 2019-12-07

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (1)
  1. The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy
    Authors:
    Mariusz Popek, Bartosz Bobula, Karolina Orzeł-Gajowik, Magdalena Zielińska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1081), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031081. - link to the publication
  1. THE EFFECT OF TRANSFORMING GROWTH FACTOR β‑1 ACTIVATION ON THE EXPRESSION OF NR1 SUBUNIT OF NMDA RECEPTOR IN A MURINE MODEL OF ACUTE LIVER FAILURE. ROLE OF THROMBOSPONDIN(S)
    Authors:
    Mariusz Popek, Magdalena Zielińska
    Conference:
    13th International Congress of Polish Neuroscience Society PTBUN 2017 (rok: 2017, ), Wydawca: Nencki Institute, Acta Neurobiologiae Experimentalis (ISSN: 0065-1400 (print), eISSN: 1689-0035) Vol: 77 No: 4
    Data:
    konferencja 28-31 Sierpień
    Status:
    Published

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