Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

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Immunomodulatory properties of nanosystems containing membrane-active compounds and their potential in therapy of drug resistant cancers.

2015/19/N/NZ6/01872

Keywords:

cancer immunology nanotechnology drug resistance

Descriptors:

  • NZ6_2: Clinical immunology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Ewelina Piktel 

Number of co-investigators in the project: 3

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 148 800 PLN

Project start date (Y-m-d): 2016-09-05

Project end date (Y-m-d): 2020-05-04

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (4)
  1. Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications
    Authors:
    Wnorowska U, Fiedoruk K, Piktel E, Prasad SV, Sulik M, Janion M, Daniluk T, Savage PB, Bucki R
    Academic press:
    Journal of Nanobiotechnology (rok: 2020, tom: 18(1), strony: 0), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12951-019-0566-z - link to the publication
  2. Peanut-shaped gold nanoparticles with shells of ceragenin CSA-131 display the ability to inhibit ovarian cancer growth in vitro and in a tumor xenograft model
    Authors:
    Piktel E, Ościłowska I, Suprewicz Ł, Depciuch J, Marcińćzyk N, Chabielska E, Wolak P, Głuszek K, Klimek J, Zieliński PM, Marzec MT, Savage PB, Parlińska-Wojtan M, Bucki R
    Academic press:
    Cancers (rok: 2021, tom: 13, strony: 5424), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13215424 - link to the publication
  3. Ceragenin CSA-13 as free molecules and attached to magnetic nanoparticle surfaces induce caspase-dependent apoptosis in human breast cancer cells via disruption of cell oxidative balance
    Authors:
    Piktel E, Prokop I, Wnorowska U, Król G, Cieśluk M, Niemirowicz K, Savage PB, Bucki R.
    Academic press:
    Oncotarget (rok: 2018, tom: 9(31), strony: 21904-21920), Wydawca: 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127
    Status:
    Published
    DOI:
    10.18632/oncotarget.25105 - link to the publication
  4. Potencjał terapeutyczny ceragenin oraz nanosystemów zawierających substancje aktywne błonowo w terapii chorób nowotworowych
    Authors:
    Piktel E, Bucki R
    Academic press:
    Postępy Polskiej Medycyny i Farmacji (rok: 2019, tom: 6, strony: 21-31), Wydawca: Naukowa Fundacja Polpharmy
    Status:
    Published
  5. Quantification of synergistic effects of ceragenin CSA-131 combined with iron oxide magnetic nanoparticles against cancer cells
    Authors:
    Piktel E, Markiewicz KH, Wilczewska AZ, Daniluk T, Chmielewska S, Niemirowicz-Laskowska K, Mystkowska J, paprocka P, Savage PB, Bucki R
    Academic press:
    International Journal of Nanomedicine (rok: 2020, tom: 15, strony: 4573-4589), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/IJN.S255170 - link to the publication
  1. Mechanical and proliferative markers of breast cancer cells upon selected nanosystems treatment
    Authors:
    Deptuła P, Piktel E, Cieśluk M, Wnorowska U, Niemirowicz K, Bucki R
    Conference:
    XIX. Annual Linz Winter Workshop (rok: 2017, ), Wydawca: Johannes Kepler University Linz, Institute for Biophysics
    Data:
    konferencja 3-6.02.2017
    Status:
    Published
  2. Zaburzenie równowagi oksydoredukcyjnej w komórkach raka piersi wywołane podaniem cerageniny CSA-13 w formie wolnej i zimmobilizowanej na magnetycznym nośniku
    Authors:
    Piktel E, Prokop I, Niemirowicz K, Wnorowska U, Savage PB, Bucki R
    Conference:
    V konferencja Związki biologicznie czynne: aktywność struktura, synteza (rok: 2017, ), Wydawca: Uniwersystet w Białymstoku
    Data:
    konferencja 9-11.06.2017
    Status:
    Published
  3. Alterations in stiffness of ovarian cancer cells as the first manifestation of anti-cancer activities of membrane active compounds
    Authors:
    Piktel E, Ciesluk M, Savage PB, Bucki R
    Conference:
    World Congress on Cancer Science and Therapy (rok: 2019, ), Wydawca: Inovine Conferences
    Data:
    konferencja 15-17.07.2019
    Status:
    Published
  4. Zwiększenie aktywności przeciwnowotworowej oraz poprawa hemokompatybilności cerageniny CSA-131 z wykorzystaniem nanocząstek magnetycznych
    Authors:
    Piktel E, Niemirowicz K, Wnorowska U, Savage PB, Bucki R
    Conference:
    60 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2017, ), Wydawca: Politechnika Wrocławska, Uniwerysytet Wrocławski
    Data:
    konferencja 17-21.09.2017
    Status:
    Published