Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Anticoagulant and antiproliferative properties of novel thrombin binding aptamer analogues

2015/19/N/NZ5/02246

Keywords:

DNA aptamer TBA modified oligonucleotide quadruplex anticoagulant fibroblasts thrombosis asthma chronic obstructive pulmonary disease

Descriptors:

  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Weronika Kotkowiak 

Number of co-investigators in the project: 2

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 49 960 PLN

Project start date (Y-m-d): 2016-08-09

Project end date (Y-m-d): 2018-02-08

Project duration:: 18 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do elektroforezy pionowej w żelu poliakrylamidowym (PAGE) z płytą chłodzącą (2 644 PLN)
  2. Blok grzejny z komorą grzejną (4 729 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Thermodynamic, anticoagulant and antiproliferative properties of thrombin binding aptamer analogues containing novel UNA derivative
    Authors:
    Weronika Kotkowiak, Jolanta Lisowiec-Wachnicka, Jakub Grynda, Ryszard Kierzek, Jesper Wengel and Anna Pasternak
    Academic press:
    Molecular Therapy: Nucleic Acid (rok: 2018, tom: 10, strony: 304-316), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.omtn.2017.12.013 - link to the publication
  2. Novel isoguanine derivative of unlocked nucleic acid-Investigations of thermodynamics and biological potential of modified thrombin binding aptamer
    Authors:
    Weronika Kotkowiak, Tomasz Czapik, Anna Pasternak
    Academic press:
    PLoS One (rok: 2018, tom: 13, strony: e0197835), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0197835 - link to the publication

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