Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Pathophysiological significance of trimethylamine N-oxide in heart failure.

2015/19/N/NZ5/00650

Keywords:

gut bacteria trimethylamine N-oxide heart failure

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ4_4: Pathophysiology
  • NZ4_2: Physiology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarsko-Dentystyczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Adrian Drapała 

Number of co-investigators in the project: 2

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 149 280 PLN

Project start date (Y-m-d): 2016-07-07

Project end date (Y-m-d): 2020-01-06

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Klatki metaboliczne (5 szt.) (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Heart Failure Disturbs Gut-Blood Barrier and Increases Plasma Trimethylamine, a Toxic Bacterial Metabolite
    Authors:
    Adrian Drapala, Mateusz Szudzik, Dawid Chabowski, Izabella Mogilnicka, Kinga Jaworska, Katarzyna Kraszewska, Emilia Samborowska, Marcin Ufnal
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 6161), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms21176161 - link to the publication
  2. Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats.
    Authors:
    Huc T, Drapala A, Gawrys M, Konop M, Bielinska K, Zaorska E, Samborowska E, Wyczalkowska-Tomasik A, Pączek L, Dadlez M, Ufnal M.
    Academic press:
    American Journal of Physiology-Heart and Circulatory Physiology. (rok: 2018, tom: 315, strony: H1805-H1820), Wydawca: AMER PHYSIOLOGICAL SOC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
    Status:
    Published
    DOI:
    10.1152/ajpheart.00536.2018 - link to the publication

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