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The APOBEC3B deletion - analysis of its role in familial breast cancer predisposition and determination of its consequences on mRNA level

2015/19/N/NZ5/02247

Keywords

Descriptors

  • NZ5_1: Etiologia chorób człowieka
  • NZ5_5: Diagnostyka chorób człowieka
  • NZ2_1: Genetyka molekularna

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Instytut Chemii Bioorganicznej PAN

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Katarzyna Klonowska

Number of co-investigators in the project: 3

Call

PRELUDIUM 10 – announced on 2015-09-15

Amount awarded
150 000 PLN
Project start date
2016-08-09
Project end date
2019-08-08
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. komputer wraz z oprogramowaniem. Cost: 3 000 PLN

Information in the final report

Publication in academic press/journals (2)

  1. Large-scale meta-analysis of mutations identified in panels of breast/ovarian cancer-related genes - Providing evidence of cancer predisposition genes

    Authors:
    Suszynska M, Klonowska K, Jasinska AJ, Kozlowski P
    Academic press:
    Gynecologic Oncology (year: 2019, volume: 153, pages: 452-462), Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
    Status:
    Published
    DOI:
    10.1016/j.ygyno.2019.01.027 – link to the publication

  2. The 30 kb deletion in the APOBEC3 cluster decreases APOBEC3A and APOBEC3B expression and creates a transcriptionally active hybrid gene but does not associate with breast cancer in the European population

    Authors:
    Klonowska K, Kluzniak W, Rusak B, Jakubowska A, Ratajska M, Krawczynska N, Vasilevska D, Czubak K, Wojciechowska M, Cybulski C, Lubinski J, Kozlowski P
    Academic press:
    Oncotarget (year: 2017, volume: 8(44), pages: 76357-76374), Publisher: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.19400 – link to the publication

Articles in post-conference publications (2)

  1. The 30 kb deletion in the APOBEC3 cluster decreases APOBEC3A and APOBEC3B expression and creates transcriptionally active hybrid gene but does not associate with breast cancer in European population

    Authors:
    K. Klonowska, W. Kluzniak, B. Rusak, K. Czubak, M. Wojciechowska, M. Ratajska, N. Krawczynska, A. Podolak, D. Vasilevska, J. Limon, C. Cybulski, J. Lubinski, P. Kozlowski
    Conference:
    European Human Genetics Conference 2017 (year: 2017, pages: -), Publisher: -
    Date:
    conference 27-30.05
    Status:
    Published

  2. The role of large deletions in BARD1 and APOBEC3B as risk factors for breast and/or ovarian cancer

    Authors:
    Katarzyna Klonowska, Piotr Kozlowski
    Conference:
    9th International Conference of Contemporary Oncology (year: 2017, pages: 16), Publisher: Termedia
    Date:
    conference 22-24.03
    Status:
    Published

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