Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Diabetes mellitus as a factor enhancing aortic stenosis progression: new molecular mechanisms

2015/19/B/NZ5/00647

Keywords:

diabetes aortic stenosis advanced glycation end products

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Krakowski Szpital Specjalistyczny im. Jana Pawła II

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Joanna Natorska 

Number of co-investigators in the project: 5

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 624 360 PLN

Project start date (Y-m-d): 2016-07-21

Project end date (Y-m-d): 2020-12-20

Project duration:: 53 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Kriostat (70 000 PLN)
  2. Specjalistyczna pipeta elektroniczna.
  3. StepOnePlus Real-Time PCR System.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (1)
  1. Phospholipids accumulation and calcification in cultured primary human aortic valve interstitial cells: New insights revealed by confocal Raman imaging
    Authors:
    Krzysztof Czamara, Magdalena Kopytek, Malgorzata Szulczewska, Agnieszka Kaczor, Joanna Natorska
    Academic press:
    Journal of Raman Spectroscopy (rok: 2020, tom: 51, strony: 104-114), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/jrs.5760 - link to the publication
  2. Accumulation of advanced glycation end products (AGEs) is associated with the severity of aortic stenosis in patients with concomitant type 2 diabetes
    Authors:
    Magdalena Kopytek, Michał Ząbczyk, Piotr Mazur, Anetta Undas, Joanna Natorska
    Academic press:
    Cardiovascular Diabetology (rok: 2020, tom: 19, strony: 92), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12933-020-01068-7 - link to the publication
  3. Diabetes concomitant to aortic stenosis enhances valvular expression of NFκB and accelerates valve calcification
    Authors:
    Magdalena Kopytek, Piotr Mazur, Michał Ząbczyk, Anetta Undas, Joanna Natorska
    Academic press:
    Diabetologia (rok: 2021, tom: 64, strony: 2562-2574), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00125-021-05545-w - link to the publication
  4. Angiotensin-converting enzyme inhibitors modulate the activation of the tissue factor pathway within aortic valves in patients with aortic stenosis: Links between blood coagulation and inflammation
    Authors:
    Natorska J, Siudut J, Mazur P, Sobczyk D, Undas A
    Academic press:
    Postepy Hig Med Dosw (rok: 2018, tom: 72, strony: 1208-1215), Wydawca: Index Copernicus
    Status:
    Published
    DOI:
    10.5604/01.3001.0012.8290 - link to the publication
  5. Aortic valvular stenosis: novel molecular pathways and their potential therapeutic implications
    Authors:
    Joanna Natorska, Magdalena Kopytek, Anetta Undas
    Academic press:
    European Journal of Clinical Investigation (rok: 2021, tom: 51, strony: e13527), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1007/s00125-021-05545-w - link to the publication
  1. Accumulation of advanced glycoxidation end products (AGEs) is associated with the severity of aortic stenosis in patients with concomitant type 2 diabetes
    Authors:
    M Kopytek, M Zabczyk, A Undas, J Natorska
    Conference:
    ESC Congress 2019 together with World Congress of Cardiology 31 August – 4 September 2019, Paris - France (rok: 2019, ), Wydawca: OXFORD ACADEMIC
    Data:
    konferencja 43708
    Status:
    Published

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