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Diabetes mellitus as a factor enhancing aortic stenosis progression: new molecular mechanisms

2015/19/B/NZ5/00647

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Krakowski Szpital Specjalistyczny im. Jana Pawła II

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Joanna Agnieszka Natorska

Number of co-investigators in the project: 5

Call

OPUS 10 – announced on 2015-09-15

Amount awarded
624 360 PLN
Project start date
2016-07-21
Project end date
2020-12-20
Project duration
53 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Kriostat. Cost: 70 000 PLN
  2. Specjalistyczna pipeta elektroniczna.
  3. StepOnePlus Real-Time PCR System.

Information in the final report

Publication in academic press/journals (5)

  1. Accumulation of advanced glycation end products (AGEs) is associated with the severity of aortic stenosis in patients with concomitant type 2 diabetes

    Authors:
    Magdalena Kopytek, Michał Ząbczyk, Piotr Mazur, Anetta Undas, Joanna Natorska
    Academic press:
    Cardiovascular Diabetology (year: 2020, volume: 19, pages: 92), Publisher: BMC
    Status:
    Published
    DOI:
    10.1186/s12933-020-01068-7 – link to the publication

  2. Aortic valvular stenosis: novel molecular pathways and their potential therapeutic implications

    Authors:
    Joanna Natorska, Magdalena Kopytek, Anetta Undas
    Academic press:
    European Journal of Clinical Investigation (year: 2021, volume: 51, pages: e13527), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1007/s00125-021-05545-w – link to the publication

  3. Angiotensin-converting enzyme inhibitors modulate the activation of the tissue factor pathway within aortic valves in patients with aortic stenosis: Links between blood coagulation and inflammation

    Authors:
    Natorska J, Siudut J, Mazur P, Sobczyk D, Undas A
    Academic press:
    Postepy Hig Med Dosw (year: 2018, volume: 72, pages: 1208-1215), Publisher: Index Copernicus
    Status:
    Published
    DOI:
    10.5604/01.3001.0012.8290 – link to the publication

  4. Diabetes concomitant to aortic stenosis enhances valvular expression of NFκB and accelerates valve calcification

    Authors:
    Magdalena Kopytek, Piotr Mazur, Michał Ząbczyk, Anetta Undas, Joanna Natorska
    Academic press:
    Diabetologia (year: 2021, volume: 64, pages: 2562-2574), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00125-021-05545-w – link to the publication

  5. Phospholipids accumulation and calcification in cultured primary human aortic valve interstitial cells: New insights revealed by confocal Raman imaging

    Authors:
    Krzysztof Czamara, Magdalena Kopytek, Malgorzata Szulczewska, Agnieszka Kaczor, Joanna Natorska
    Academic press:
    Journal of Raman Spectroscopy (year: 2020, volume: 51, pages: 104-114), Publisher: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/jrs.5760 – link to the publication

Articles in post-conference publications (1)

  1. Accumulation of advanced glycoxidation end products (AGEs) is associated with the severity of aortic stenosis in patients with concomitant type 2 diabetes

    Authors:
    M Kopytek, M Zabczyk, A Undas, J Natorska
    Conference:
    ESC Congress 2019 together with World Congress of Cardiology 31 August – 4 September 2019, Paris - France (year: 2019, pages: 1124), Publisher: OXFORD ACADEMIC
    Date:
    conference 43708
    Status:
    Published

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