Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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RAN translation at CAG repeats in spinocerebellar ataxia type 3

2015/19/D/NZ5/02183

Keywords:

polyglutamine diseases expanded CAG repeats RAN translation toxicity of RAN-translated proteins

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ3_6: Cell neurobiology
  • NZ2_3: Proteomics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Jazurek-Ciesiołka 

Number of co-investigators in the project: 6

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 699 048 PLN

Project start date (Y-m-d): 2016-09-01

Project end date (Y-m-d): 2023-02-28

Project duration:: 78 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. pompa do perfuzji (12 000 PLN)
  2. Aparat do elektroforezy i transferu białek z wyposażeniem.

Information in the final report

  • Publication in academic press/journals (3)
  1. Identifying proteins that bind to specific RNAs - focus on simple repeat expansion diseases
    Authors:
    Jazurek M., Ciesiolka A., Starega-Roslan J., Bilinska K., Krzyzosiak W.J.
    Academic press:
    Nucleic Acids Research (rok: 2016, tom: 44, strony: 9050-9070), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkw803 - link to the publication
  2. Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions
    Authors:
    Ciesiolka A., Jazurek M., Drazkowska K., Krzyzosiak W.J.
    Academic press:
    Frontiers in Cellular Neuroscience (rok: 2017, tom: 11, strony: 97), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fncel.2017.00097 - link to the publication
  3. RAN translation of the expanded CAG repeats in the SCA3 disease context
    Authors:
    Magdalena Jazurek-Ciesiolka, Adam Ciesiolka, Alicja A. Komur, Martyna O. Urbanek-Trzeciak, Wlodzimierz J. Krzyzosiak, Agnieszka Fiszer
    Academic press:
    Journal of Molecular Biology (rok: 2020, tom: 432, strony: 166699), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.033 - link to the publication

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