Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Amphiphilic polymers for the controlled disruption of the cell membrane: stimuli responsive action, activity against Mycobacterium

2015/18/E/ST5/00222

Keywords:

stimuli responsive polymers antimicrobial polymers amphiphilic polymers disruption of cell membrane mycobaterium

Descriptors:

  • ST5_12: Methods of nanomaterials/materials synthesis
  • ST5_16:
  • NZ6_4: Bacteriology

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Warszawska, Wydział Chemiczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Dominik Jańczewski 

Number of co-investigators in the project: 13

Call: SONATA BIS 5 - announced on 2015-06-15

Amount awarded: 1 975 200 PLN

Project start date (Y-m-d): 2016-06-01

Project end date (Y-m-d): 2022-05-31

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. reaktor mikrofalowy (150 000 PLN)
  2. spektrofluorymetr.
  3. lodówka laboratoryjna (8 052 PLN)
  4. liofilizator (150 000 PLN)
  5. waga analityczna (3 750 PLN)
  6. waga analityczna.

Information in the final report

  • Publication in academic press/journals (8)
  1. Hydrophilic Quaternary Ammonium Ionenes - Is There an Influence of Backbone Flexibility and Topology on Antibacterial Properties?
    Authors:
    Rafał Jerzy Kopiasz, Waldemar Tomaszewski, Aleksandra Kuźmińska, Karolina Chreptowicz, Jolanta Mierzejewska, Tomasz Ciach, Dominik Jańczewski
    Academic press:
    Macromolecular Bioscience (rok: 2020, tom: 20, strony: 2000063), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/mabi.202000063 - link to the publication
  2. Influence of PEG Subunit on the Biological Activity of Ionenes: Synthesis of Novel Polycations, Antimicrobial and Toxicity Studies. Macromol. Biosci. 2022.
    Authors:
    Kopiasz, R. J.; Kulbacka, N.; Drężek, K.; Podgórski, R.; Łojszczyk, K.; Mierzejewska, J.; Ciach, T.; Augustynowicz-Kopeć, E.; Głogowska, A.; Iwańska, A.; Tomaszewski, W.; Jańczewski, D.
    Academic press:
    Macromolecular Bioscience (rok: 2022, tom: 22, strony: 2200094), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/mabi.202200094 - link to the publication
  3. Influence of lipid bilayer composition on the activity of antimicrobial quaternary ammonium ionenes, the interplay of intrinsic lipid curvature and polymer hydrophobicity, the role of cardiolipin
    Authors:
    Kopiasz, R. J.; Rukasz, A.; Chreptowicz, K.; Podgórski, R.; Kuźmińska, A.; Mierzejewska, J.; Tomaszewski, W.; Ciach, T.; Jańczewski, D.
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2021, tom: 207, strony: 112016), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2021.112016 - link to the publication
  4. Unusual enhancement of degradation rate induced by polymer chain elongation in quaternized polyethyleneimine derivatives
    Authors:
    Rafał J. Kopiasz, Michał Szczepańczyk, Dominik Jańczewski
    Academic press:
    Reactive and Functional Polymers (rok: 2019, tom: 137, strony: 96-103), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.reactfunctpolym.2019.01.010 - link to the publication
  5. Amphiphilic Polymethyloxazoline–Polyethyleneimine Copolymers: Interaction with Lipid Bilayer and Antibacterial Properties
    Authors:
    Dominika Kozon, Jolanta Mierzejewska, Tomasz Kobiela, Agnieszka Grochowska, Ksenia Dudnyk, Agnieszka Głogowska, Anna Sobiepanek, Aleksandra Kuźmińska, Tomasz Ciach, Ewa Augustynowicz-Kopeć, Dominik Jańczewski
    Academic press:
    Macromolecular Bioscience (rok: 2019, tom: 19, strony: 1900254), Wydawca: WILEY-VCH
    Status:
    Published
    DOI:
    10.1002/mabi.201900254 - link to the publication
  6. Controlled post-polymerization modification through modulation of repeating unit reactivity: proof of concept discussed using linear polyethylenimine example
    Authors:
    Rafał J. Kopiasz, Dominika Kozon, Julita Pachla, Łukasz Skórka, Dominik Jańczewski
    Academic press:
    Polymer (rok: 2021, tom: 217, strony: 123452), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.polymer.2021.123452 - link to the publication
  7. Main-chain flexibility and hydrophobicity of ionenes strongly impact their antimicrobial activity: an extended study on drug resistance strains and Mycobacterium
    Authors:
    Rafał Jerzy Kopiasz, Anna Zabost, Magdalena Myszka, Aleksandra Kuzmińska, Karolina Drężek, Jolanta Mierzejewska, Waldemar Tomaszewski, Agnieszka Iwanska, Ewa Augustynowicz-Kopec, Tomasz Ciach, Dominik Jańczewski
    Academic press:
    RSC Advances (rok: 2022, tom: 12, strony: 26220–26232), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/D2RA04121A - link to the publication
  8. Regulation of Lipid Bilayer Ion Permeability by Antibacterial Polymethyloxazoline-Polyethyleneimine Copolymers
    Authors:
    Dominika Kozon, Piotr Bednarczyk, Adam Szewczyk, Dominik Jańczewski
    Academic press:
    ChemBioChem (rok: 2021, tom: 22, strony: 1020-1029), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cbic.202000656 - link to the publication

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