Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Magnetic Resonance Spectroscopy Evaluation of Brain Metabolites Following Microbiotic Diet

2015/17/B/NZ4/02986

Keywords:

MRS MRI GABA serotonin probiotics depression

Descriptors:

  • NZ4_10: Neuroimaging and computational neuroscience
  • NZ4_9: Systems neurobiology
  • NZ4_7: Neurophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Lekarski

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Grzegorz Stanisz 

Number of co-investigators in the project: 7

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 148 377 PLN

Project start date (Y-m-d): 2016-03-17

Project end date (Y-m-d): 2022-02-16

Project duration:: 71 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Cewki szczurze dla skanera do głowy 7T dla potrzeb spektroskopii protonowej MR (1H MRS) (80 000 PLN)
  2. Licencje MATLAB.
  3. Adapter dla szczura do skanera 7T (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (15)
  1. Saturation transfer MRI is sensitive to neurochemical changes in the rat brain due to chronic unpredictable mild stress
    Authors:
    Anna Pankowska, Agata Chudzik, Tymoteusz Słowik, Artur Łazorczyk, Katarzyna Kochalska, Marta Andres‑Mach, Wilfred W. Lam, Radosław Pietura, Radosław Rola, Greg J. Stanisz, Anna Orzyłowska
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 19040), Wydawca: Springer Nature Limited
    Status:
    Published
    DOI:
    10.1038/s41598-021-97991-0 - link to the publication
  2. Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress
    Authors:
    Katarzyna Kochalska, Wendy Oakden, Tymoteusz Słowik, Agata Chudzik, Anna Pankowska, Artur Łazorczyk, Paulina Kozioł, Marta Andres-Mach, Radosław Pietura, Radosław Rola, Greg J. Stanisz, Anna Orzyłowska
    Academic press:
    Nutrition Research (rok: 2020, tom: 82, strony: 44-57), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.nutres.2020.06.019 - link to the publication
  3. Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome Axis
    Authors:
    Agata Chudzik, Anna Orzyłowska, Radosław Rola, Greg J. Stanisz
    Academic press:
    Biomolecules (rok: 2021, tom: 11, strony: 1000), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom11071000 - link to the publication
  4. Continuous ingestion of Lacticaseibacillus rhamnosus JB-1 during chronic stress ensures neurometabolic and behavioural stability in rats
    Authors:
    Agata Chudzik, Tymoteusz Słowik, Katarzyna Kochalska, Anna Pankowska, Artur Łazorczyk, Marta Andres‑Mach, Radosław Rola, Greg J. Stanisz, Anna Orzyłowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 5173), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23095173 - link to the publication
  5. Saturation Transfer MRI for Detection of Metabolic and Microstructural Impairments Underlying Neurodegeneration in Alzheimer's Disease
    Authors:
    Anna Orzyłowska, Wendy Oakden
    Academic press:
    Brain Sciences (rok: 2022, tom: 12, strony: 53), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/brainsci12010053 - link to the publication
  1. 7T 1H MRS for detection of immediate cerebral response to probiotic treatment in rat model of depressive disorder
    Authors:
    Anna Orzyłowska, Artur Łazorczyk, Paulina Kozioł, Agata Chudzik, Katarzyna Kochalska, Tymoteusz Słowik, Anna Pankowska, Radosław Rola, Greg J. Stanisz
    Conference:
    10th Kraków Workshop on Novel Applications of Imaging and Spectroscopy in Medicine, Biology and Material Sciences (rok: 2019, ), Wydawca: Instytut Fizyki Jądrowej PAN
    Data:
    konferencja 43731
    Status:
    Published
  2. Czy suplementacja diety mikrobiotykami zmienia zachowanie? Suplementacja diety bakteriami Lactobacillus rhamnosus JB-1™ w modelu przewlekłego umiarkowanego nieprzewidywalnego stresu (CUMS) u szczurów
    Authors:
    Agata Chudzik, Tymoteusz Słowik, Anna Orzyłowska, Marta Andres-Mach, Radosław Rola, Grzegorz Stanisz
    Conference:
    V Kuźnia Młodych Talentów AMU PAN (rok: 2019, ), Wydawca: Akademia Młodych Uczonych Polskiej Akademii Nauk
    Data:
    konferencja 43648
    Status:
    Published
  3. Effects of prolonged anesthesia with isoflurane on cerebral neurochemical profile as assessed by 1H MRS
    Authors:
    Agata Chudzik, Anna Orzyłowska, Katarzyna Kochalska, Artur Łazorczyk, Tymoteusz Słowik, Radosław Rola, Greg J. Stanisz
    Conference:
    10th Kraków Workshop on Novel Applications of Imaging and Spectroscopy in Medicine, Biology and Material Sciences (rok: 2019, ), Wydawca: Instytut Fizyki Jądrowej PAN
    Data:
    konferencja 43731
    Status:
    Published
  4. Evaluation of neurometabolites level after microbiotic supplementation (Lactobacillus rhamnosus LR-JB1™) in rat model of chronic unpredictable mild stress
    Authors:
    Agata Chudzik, Anna Orzyłowska, Tymoteusz Słowik, Katarzyna Kochalska, Artur Łazorczyk, Anna Pankowska, Radosław Rola, Greg Stanisz
    Conference:
    7th ISM World Congress on Targeting Microbiota (rok: 2019, ), Wydawca: International Society of Microbiota
    Data:
    konferencja 43748
    Status:
    Published
  5. Molecular imaging of depression-related brain metabolites using CEST technique - phantom study
    Authors:
    A. Pankowska, K. Kochalska, A. Orzylowska, W. Lam, A. Wojtowicz, T. Slowik, A. Lazorczyk, R. Pietura, R. Rola, G. Stanisz
    Conference:
    9th International Workshop on Biomedical Applications of MRI and MRS, Krakow (rok: 2017, ), Wydawca: IFJ
    Data:
    konferencja wrzesien
    Status:
    Published
  6. Effect of lipid removal from the rat brain sample with the CLARITY procedure on the CEST spectrum in 7T MRI
    Authors:
    Tymoteusz Słowik, Agata Chudzik, Anna Pankowska, Wilfred W. Lam, Anna Orzyłowska, Radosław Rola, Greg Stanisz
    Conference:
    10th Kraków Workshop on Novel Applications of Imaging and Spectroscopy in Medicine, Biology and Material Sciences (rok: 2019, ), Wydawca: Instytut Fizyki Jądrowej PAN
    Data:
    konferencja 43731
    Status:
    Published
  7. Immediate elevation of GABA in rat brain after feeding with Lactobacillus rhamnosus JB-1 - the gut-brain axis study of animal model of depressive disorder
    Authors:
    Anna Orzyłowska, Agata Chudzik, Artur Łazorczyk, Paulina Kozioł, Katarzyna Kochalska, Tymoteusz Słowik, Anna Pankowska, Radosław Rola, Greg Stanisz
    Conference:
    7th ISM World Congress on Targeting Microbiota (rok: 2019, ), Wydawca: International Society of Microbiota
    Data:
    konferencja 43748
    Status:
    Published
  8. The CLARITY procedure of lipid removal from brain ssue sample reveals the lipid-origin of MT contrast in CEST imaging experiment
    Authors:
    Anna Orzylowska, Tymoteusz Słowik, Agata Chudzik, Anna Pankowska, Wilfred W Lam, Greg J Stanisz
    Conference:
    ISMRM & SMRT Virtual Conference & Exhibition (rok: 2020, ), Wydawca: ISMRM
    Data:
    konferencja 08-14 sierpnia 2020
    Status:
    Published
  9. Chemical Exchnage Saturation Transfer and Magnetic Resonance Spectroscopy for the evaluation of brain metabolic response to probiotic diet in animal model of depressive disorders
    Authors:
    A. Orzylowska, K. Kochalska, A. ZUbik, W. Lam, T. SLowik, A. Lazorczyk, M. Andres-Mach, R. Rola, GJ. Stanisz
    Conference:
    Music-CEST (rok: 2017, ), Wydawca: Vanderbilt University
    Data:
    konferencja sierpien
    Status:
    Published
  10. In vivo 1H MRS study at 7T for the assessment of metabolic changes in the rat model of chronic unpredicted mild stress protocol (CUMS) with and without Lactobacillus rhamnosus (JB 1) treatment.
    Authors:
    Katarzyna Kochalska, Anna Pankowska, Anna Orzylowska, Artur Lazorczyk Tymoteusz Slowik, Marta Andres – Mach, Radoslaw Rola, Radoslaw Pietura, Greg Stanisz
    Conference:
    9th International Workshop on Biomedical Applications of MRI and MRS, Krakow (rok: 2017, ), Wydawca: IFJ
    Data:
    konferencja wrzesien
    Status:
    Published
  11. In vivo 1H MRS study at 7T for the assessment of metabolic changes in the rat model of chronic unpredictable mild stress with Lactobacillus rhamnosus (JB-1) treatment
    Authors:
    Katarzyna Kochalska, Wendy Oakden, Anna Pankowska, Anna Orzylowska, Artur Lazorczyk, Tymoteusz Slowik, Radoslaw Rola, Radoslaw Pietura, Greg Stanisz
    Conference:
    MRS workshop in Utrecht (rok: 2018, ), Wydawca: ISMRM
    Data:
    konferencja 8 października
    Status:
    Published
  12. Influence of microbiotic supplementation (Lactobacillus rhamnosus JB-1™) on behavioural and brain metabolic changes in rat model of Chronic Unpredicted Mild Stress
    Authors:
    Agata Chudzik, Tymoteusz Słowik, Anna Orzyłowska, Marta Andres-Mach, Anna Pankowska, Artur Łazorczyk, Radosław Rola, Greg J Stanisz
    Conference:
    14th International Symposium Molecular Basis of Pathology and Therapy in Neurological Disorders (rok: 2018, ), Wydawca: Mossakowski Medical Research Centre in Warsaw, PAN
    Data:
    konferencja 25-26 pażdziernika
    Status:
    Published
  13. Microbiotic supplementation with Lactobacillus rhamnosus JB-1 ensures neurometabolic and behavioural stability in rats subjected to chronic stress
    Authors:
    Agata Chudzik, Anna Orzylowska, Tymoteusz Slowik, Katarzyna Kochalska, Artur Lazorczyk, Anna Pankowska, Radoslaw Rola, Greg J Stanisz
    Conference:
    Miami Winter Symposium 2020 - Molecular Mechanisms Linking the Microbiome and Human Health (rok: 2020, ), Wydawca: Elsevier Inc.
    Data:
    konferencja 26-29 stycznia 2020
    Status:
    Published
  14. CEST and MRS for the Evaluation of Brain Metabolic Response to Probiotic Diet in Animal Model of Depressive Disorders
    Authors:
    A. Orzyłowska, K. Kochalska A. Zubik, W. Lam, T. Słowik, A. Łazorczyk, M. Andres-Mach, R. Rola, G. J. Stanisz
    Conference:
    9th International Workshop on Biomedical Applications of MRI and MRS, Krakow (rok: 2017, ), Wydawca: IFJ
    Data:
    konferencja wrzesien
    Status:
    Published
  15. Using chemical exchange saturation transfer method for comparison of metabolite levels changes in the animal model of chronic unpredicted mild stress
    Authors:
    Anna Pankowska, Artur Łazorczyk, Katarzyna Kochalska, Agata Chudzik, Tymoteusz Słowik, Marta Andres-Mach, Wilfred W. Lam, Radosław Pietura, Radosław Rola, Greg Stanisz, Anna Orzyłowska
    Conference:
    10th Kraków Workshop on Novel Applications of Imaging and Spectroscopy in Medicine, Biology and Material Sciences (rok: 2019, ), Wydawca: Instytut Fizyki Jądrowej PAN
    Data:
    konferencja 43731
    Status:
    Published

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