Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Comprehensive analysis of the role of selected miRNA in the pathogenesis of primary biliary cirrhosis of the liver.

2015/17/B/NZ5/02541

Keywords:

microRNA cholestasis autoimmune diseases

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Nauk o Zdrowiu

woj. zachodniopomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Milkiewicz 

Number of co-investigators in the project: 3

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 466 680 PLN

Project start date (Y-m-d): 2016-02-25

Project end date (Y-m-d): 2021-02-24

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Enhanced expression of miRNA-21 and miRNA-150 is a typical feature of anti-mitochondrial antibody-negative Primary Biliary Cholangitis
    Authors:
    Urszula Wasik , Agnieszka Kempinska-Podhorodecka, Dimitros P. Bogdanos, Piotr Milkiewicz, Malgorzata Milkiewicz
    Academic press:
    Molecular Medicine (rok: 2020, tom: 1,08888888888889, strony: 45522), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s10020-019-0130-1 - link to the publication
  2. Protection against oxidative stress mediated by the Nrf2/Keap1 axis is impaired in primary biliary cholangiti
    Authors:
    Urszula Wasik, Małgorzata Milkiewicz, Agnieszka Kempinska-Podhorodecka, Piotr Milkiewicz
    Academic press:
    Scientific Reports (rok: 2016, tom: brak, strony: 7:44769), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/srep44769 - link to the publication
  3. Decreased Expression of Vitamin D Receptor Affects an Immune Response in Primary Biliary Cholangitis via the VDR-miRNA155-SOCS1 Pathway.
    Authors:
    Kempinska-Podhorodecka A, Milkiewicz M, Wasik U, Ligocka J, Zawadzki M, Krawczyk M, Milkiewicz P.
    Academic press:
    Int J Mol Sci. (rok: 2016, tom: 18, strony: brak), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms18020289 - link to the publication
  4. Oncomir MicroRNA-346 is upregulated in colons of patients with primary sclerosing cholangitis
    Authors:
    Kempińska-Podhorodecka Agnieszka, Blatkiewicz Małgorzata, Wunsch Ewa, Krupa Łukasz, Gutkowski Krzysztof, Milkiewicz Piotr, Milkiewicz Małgorzata.
    Academic press:
    Clinical and Translational Gastroenterology (rok: 2020, tom: vol. 11,, strony: e00112, 8s), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.14309/ctg.0000000000000112 - link to the publication
  5. Role of miR-506 in ulcerative colitis associated with primary sclerosing cholangitis
    Authors:
    Agnieszka Kempinska-Podhorodecka, Monika Adamowicz , Ewa Ostrycharz, Mateusz Chmielarz, Maciej Wójcicki, Piotr Milkiewicz, Malgorzata Milkiewicz
    Academic press:
    Scientific Reports , Wydawca: Nature
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  6. Melatonin Protects Cholangiocytes from Oxidative Stress-Induced Proapoptotic and Proinflammatory Stimuli via miR-132 and miR-34
    Authors:
    Ewa Ostrycharz, Urszula Wasik, Agnieszka Kempinska-Podhorodecka, Jesus M. Banales, Piotr Milkiewicz, and Malgorzata Milkiewicz
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, 9667;, strony: art. 9667, 13 s), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390 - link to the publication

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