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Changes in iron metabolism induced by anticancer compounds in in vitro and in vivo

2015/17/B/NZ7/03058

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia
  • NZ7_12: Prewencja chorób człowieka
  • NZ7_15: Toksykologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Gdański Uniwersytet Medyczny, Wydział Nauk o Zdrowiu z Instytutem Medycyny Morskiej i Tropikalnej

Voivodeship: pomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Jędrzej Antosiewicz

Number of co-investigators in the project: 5

Call

OPUS 9 – announced on 2015-03-16

Amount awarded
1 039 000 PLN
Project start date
2016-04-27
Project end date
2021-04-26
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do transferu białek. Cost: 10 000 PLN
  2. Autoklaw. Cost: 15 000 PLN
  3. Chromatograf GC.
  4. Komputer. Cost: 4 000 PLN
  5. Spektrometr IR. Cost: 95 000 PLN
  6. Waga analityczna o wysokiej czułości. Cost: 5 000 PLN
  7. Zakup apartau do elektorforezy białek (2 pcs). Cost: 8 000 PLN
  8. Zestaw do elektroforezy i transferu białek (3 elementy).
  9. Łaźnia Wodna. Cost: 8 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. Water-dependent synthesis of biologically active diaryl diselenides

    Authors:
    Agata J. Pacuła, Magdalena Obieziurska, Jacek Ścianowski, Katarzyna B. Kaczor, Jędrzej Antosiewicz
    Academic press:
    ARKIVOC (year: 2018, volume: 2018, pages: 153-164), Publisher: Arkat USA
    Status:
    Published
    DOI:
    10.24820/ark.5550190.p010.311 – link to the publication

  2. The Influence of O/S Exchange on the Biocatalytical Activity of Benzisoselenazol-3(2H)-ones,

    Authors:
    M. Obieziurska, A. J. Pacula, U. Juhas, J. Antosiewicz and J. Scianowski,
    Academic press:
    Catalysts, vol. 8, (year: 2018, volume: 8, pages: 46036), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/catal8110493 – link to the publication

  3. New Chiral Ebselen Analogues with Antioxidant and Cytotoxic Potential

    Authors:
    Agata J. Pacuła 1, Katarzyna B. Kaczor 2, Jędrzej Antosiewicz 2,5, Anna Janecka 3, Angelika Długosz 3, Tomasz Janecki 4, Andrzej Wojtczak 1 and Jacek Ścianowski
    Academic press:
    Molecules (year: 2017, volume: 22, pages: b.d.), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules22030492 – link to the publication

  4. In Vitro Anti-Prostate Cancer Activity of Two Ebselen Analogues

    Authors:
    Katarzyna B. Kaczor-Keller, Anna Pawlik, Jacek Scianowski , Agata Pacuła, Magdalena Obieziurska, Fabio Marcheggiani, Ilenia Cirilli, Luca Tiano and Jedrzej Antosiewicz
    Academic press:
    Pharmaceuticals (year: 2020, volume: 13, pages: 47), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ph13030047 – link to the publication

  5. New glutathione peroxidase mimetics—Insights into antioxidant and cytotoxic activity

    Authors:
    Agata J. Pacuła a, Katarzyna B. Kaczor b, Angelika Wojtowicz b, Je ̨ drzej Antosiewicz b, Anna Janecka c, Angelika Długosz c, Tomasz Janecki d, Jacek S ́ cianowski a,⇑
    Academic press:
    Bioorganic & Medicinal Chemistry (year: 2017, volume: 25, pages: 126–131), Publisher: Elsevire
    Status:
    Published
    DOI:
    10.1016/j.bmc.2016.10.018 – link to the publication

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