Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Changes in iron metabolism induced by anticancer compounds in in vitro and in vivo

2015/17/B/NZ7/03058

Keywords:

iron cancer hepcidin protein kinases

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_12: Prevention of human diseases
  • NZ7_15: Toxicology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Nauk o Zdrowiu z Instytutem Medycyny Morskiej i Tropikalnej

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jędrzej Antosiewicz 

Number of co-investigators in the project: 5

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 039 000 PLN

Project start date (Y-m-d): 2016-04-27

Project end date (Y-m-d): 2021-04-26

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do transferu białek (10 000 PLN)
  2. Spektrometr IR (95 000 PLN)
  3. Waga analityczna o wysokiej czułości (5 000 PLN)
  4. Chromatograf GC.
  5. Zestaw do elektroforezy i transferu białek (3 elementy).
  6. Autoklaw (15 000 PLN)
  7. Zakup apartau do elektorforezy białek (2 szt.) (8 000 PLN)
  8. Komputer (4 000 PLN)
  9. Łaźnia Wodna (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. New glutathione peroxidase mimetics—Insights into antioxidant and cytotoxic activity
    Authors:
    Agata J. Pacuła a, Katarzyna B. Kaczor b, Angelika Wojtowicz b, Je ̨ drzej Antosiewicz b, Anna Janecka c, Angelika Długosz c, Tomasz Janecki d, Jacek S ́ cianowski a,⇑
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2017, tom: 25, strony: 126–131), Wydawca: Elsevire
    Status:
    Published
    DOI:
    10.018 - link to the publication
  2. The Influence of O/S Exchange on the Biocatalytical Activity of Benzisoselenazol-3(2H)-ones,
    Authors:
    M. Obieziurska, A. J. Pacula, U. Juhas, J. Antosiewicz and J. Scianowski,
    Academic press:
    Catalysts, vol. 8, (rok: 2018, tom: 8, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/catal8110493 - link to the publication
  3. Water-dependent synthesis of biologically active diaryl diselenides
    Authors:
    Agata J. Pacuła, Magdalena Obieziurska, Jacek Ścianowski, Katarzyna B. Kaczor, Jędrzej Antosiewicz
    Academic press:
    ARKIVOC (rok: 2018, tom: 2018, strony: 153-164), Wydawca: Arkat USA
    Status:
    Published
    DOI:
    10.311 - link to the publication
  4. In Vitro Anti-Prostate Cancer Activity of Two Ebselen Analogues
    Authors:
    Katarzyna B. Kaczor-Keller, Anna Pawlik, Jacek Scianowski , Agata Pacuła, Magdalena Obieziurska, Fabio Marcheggiani, Ilenia Cirilli, Luca Tiano and Jedrzej Antosiewicz
    Academic press:
    Pharmaceuticals (rok: 2020, tom: 13, strony: 47), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph13030047 - link to the publication
  5. New Chiral Ebselen Analogues with Antioxidant and Cytotoxic Potential
    Authors:
    Agata J. Pacuła 1, Katarzyna B. Kaczor 2, Jędrzej Antosiewicz 2,5, Anna Janecka 3, Angelika Długosz 3, Tomasz Janecki 4, Andrzej Wojtczak 1 and Jacek Ścianowski
    Academic press:
    Molecules (rok: 2017, tom: 22, strony: b.d.), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules22030492 - link to the publication

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