Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Long term survival and oxidative stress in hyperhomocysteinemia

2015/17/D/NZ5/03444

Keywords:

long term survival oxidative stress hyperhomocysteinemia mice cell lines

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_4: Pathogenesis of animal diseases
  • NZ1_2: Biochemistry

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Sikora 

Number of co-investigators in the project: 3

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 618 200 PLN

Project start date (Y-m-d): 2016-01-28

Project end date (Y-m-d): 2020-07-27

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer z drukarką i oprogramowaniem (7 000 PLN)
  2. zamrażarka niskotemperaturowa do -86 C (40 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (7)
  1. Cystathionine β-synthase deficiency: different changes in proteomes of thrombosis-resistant Cbs−/− mice and thrombosis-prone CBS−/− humans
    Authors:
    Marta Sikora, Izabela Lewandowska, Łukasz Marczak, Ewa Bretes & Hieronim Jakubowski
    Academic press:
    Scientific Reports (rok: 2020, tom: 10, strony: 10726), Wydawca: Nature Publishing Group (Nature Research)
    Status:
    Published
    DOI:
    10.1038/s41598-020-67672-5 - link to the publication
  2. Changes in redox plasma proteome of Pon1 -/- mice are exacerbated by a hyperhomocysteinemic diet
    Authors:
    Marta Sikora, Hieronim Jakubowski
    Academic press:
    Free Radical Biology and Medicine (rok: 2021, tom: 169, strony: 169-180), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2021.03.042 - link to the publication
  3. Sex affects N-homocysteinylation at lysine residue 212 of albumin in mice
    Authors:
    M. Sikora, L. Marczak, J. Perla-Kajan, H. Jakubowski
    Academic press:
    SCIENTIFIC REPORTS (rok: 2019, tom: 9, strony: 2669), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-38784-4 - link to the publication
  1. Label-free proteomic analysis of plasma of cystathionine β-synthase deficient mice and humans reveals changes in blood coagulation, hemostasis and antioxidant activity
    Authors:
    Marta Sikora,Izabela Bielińska ,Łukasz Marczak, Hieronim Jakubowski
    Conference:
    11th International Conference on Homocysteine and One Carbon Metabolism, Aarhus , Dania (rok: 2017, ), Wydawca: Aarhus University
    Data:
    konferencja 14-18.05
    Status:
    Published
    DOI:
    link to the publication
  2. Sex affects homocysteine modification at lysine residue 212 of albumin in mice
    Authors:
    Marta Sikora, Łukasz Marczak, Joanna Perła-Kajan, Hieronim Jakubowski
    Conference:
    3rd Congress BIO 2018, Gdańsk (rok: 2018, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 18-21.09
    Status:
    Published
    DOI:
    link to the publication
  3. Sex affects homocysteine modification at lysine residue 212 of albumin in mice
    Authors:
    Marta Sikora, Łukasz Marczak, Joanna Perła-Kajan, Hieronim Jakubowski
    Conference:
    12 th Central and Eastern European Proteomic Conference (CEEPC), Bucharest, Romania (rok: 2018, ), Wydawca: Central and Eastern European Proteomic Conference
    Data:
    konferencja 24-26.10
    Status:
    Published
    DOI:
    link to the publication
  4. Cystathionine β-synthase deficiency elevates N-homocysteinylation at specific lysine residues in fibrinogen and serum albumin in mice
    Authors:
    Marta Sikora, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    2nd Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2016" Wrocław 2016 (rok: 2016, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 13-16.09.2016
    Status:
    Published
    DOI:
    link to the publication
  5. Label-free proteomic analysis reveals changes in blood coagulation and red-ox homeostasis in the heart of cystathionine beta-synthase deficient mice
    Authors:
    I. Lewandowska, M. Sikora, H. Jakubowski
    Conference:
    44th FEBS Congress 2019 (rok: 2019, ), Wydawca: FEBS OPEN BIO/FEBS PRESS
    Data:
    konferencja 43652
    Status:
    Published
  6. Methionine-induced hyperhomocysteinemia causes changes in the mouse kidney proteome associated with blood coagulation
    Authors:
    Izabela Bielińska, Marta Sikora, Hieronim Jakubowski
    Conference:
    12 th Central and Eastern European Proteomic Conference (CEEPC), Bucharest, Romania (rok: 2018, ), Wydawca: Central and Eastern European Proteomic Conference
    Data:
    konferencja 24-26.10
    Status:
    Published
    DOI:
    link to the publication
  7. Methionine-induced hyperhomocysteinemia causes changes in the mouse kidney proteome associated with blood coagulation
    Authors:
    Izabela Bielińska, Marta Sikora, Hieronim Jakubowski
    Conference:
    3rd Congress BIO 2018, Gdańsk (rok: 2018, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 18-21.09
    Status:
    Published
    DOI:
    link to the publication

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