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Long term survival and oxidative stress in hyperhomocysteinemia

2015/17/D/NZ5/03444

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ5_4: Patogeneza chorób zwierząt
  • NZ1_2: Biochemia

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Instytut Chemii Bioorganicznej PAN

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Marta Sikora

Number of co-investigators in the project: 3

Call

SONATA 9 – announced on 2015-03-16

Amount awarded
618 200 PLN
Project start date
2016-01-28
Project end date
2020-07-27
Project duration
54 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer z drukarką i oprogramowaniem. Cost: 7 000 PLN
  2. zamrażarka niskotemperaturowa do -86 C. Cost: 40 000 PLN

Information in the final report

Publication in academic press/journals (3)

  1. Changes in redox plasma proteome of Pon1 -/- mice are exacerbated by a hyperhomocysteinemic diet

    Authors:
    Marta Sikora, Hieronim Jakubowski
    Academic press:
    Free Radical Biology and Medicine (year: 2021, volume: 169, pages: 169-180), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2021.03.042 – link to the publication

  2. Sex affects N-homocysteinylation at lysine residue 212 of albumin in mice

    Authors:
    M. Sikora, L. Marczak, J. Perla-Kajan, H. Jakubowski
    Academic press:
    SCIENTIFIC REPORTS (year: 2019, volume: 9, pages: 2669), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-38784-4 – link to the publication

  3. Cystathionine β-synthase deficiency: different changes in proteomes of thrombosis-resistant Cbs−/− mice and thrombosis-prone CBS−/− humans

    Authors:
    Marta Sikora, Izabela Lewandowska, Łukasz Marczak, Ewa Bretes & Hieronim Jakubowski
    Academic press:
    Scientific Reports (year: 2020, volume: 10, pages: 10726), Publisher: Nature Publishing Group (Nature Research)
    Status:
    Published
    DOI:
    10.1038/s41598-020-67672-5 – link to the publication

Articles in post-conference publications (7)

  1. Sex affects homocysteine modification at lysine residue 212 of albumin in mice

    Authors:
    Marta Sikora, Łukasz Marczak, Joanna Perła-Kajan, Hieronim Jakubowski
    Conference:
    12 th Central and Eastern European Proteomic Conference (CEEPC), Bucharest, Romania (year: 2018, pages: 87), Publisher: Central and Eastern European Proteomic Conference
    Date:
    conference 24-26.10
    Status:
    Published
    DOI:
    link to the publication

  2. Label-free proteomic analysis reveals changes in blood coagulation and red-ox homeostasis in the heart of cystathionine beta-synthase deficient mice

    Authors:
    I. Lewandowska, M. Sikora, H. Jakubowski
    Conference:
    44th FEBS Congress 2019 (year: 2019, pages: 407-408), Publisher: FEBS OPEN BIO/FEBS PRESS
    Date:
    conference 43652
    Status:
    Published

  3. Sex affects homocysteine modification at lysine residue 212 of albumin in mice

    Authors:
    Marta Sikora, Łukasz Marczak, Joanna Perła-Kajan, Hieronim Jakubowski
    Conference:
    3rd Congress BIO 2018, Gdańsk (year: 2018, pages: 125), Publisher: Acta Biochimica Polonica
    Date:
    conference 18-21.09
    Status:
    Published
    DOI:
    link to the publication

  4. Methionine-induced hyperhomocysteinemia causes changes in the mouse kidney proteome associated with blood coagulation

    Authors:
    Izabela Bielińska, Marta Sikora, Hieronim Jakubowski
    Conference:
    3rd Congress BIO 2018, Gdańsk (year: 2018, pages: 125), Publisher: Acta Biochimica Polonica
    Date:
    conference 18-21.09
    Status:
    Published
    DOI:
    link to the publication

  5. Cystathionine β-synthase deficiency elevates N-homocysteinylation at specific lysine residues in fibrinogen and serum albumin in mice

    Authors:
    Marta Sikora, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    2nd Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2016 Wrocław 2016 (year: 2016, pages: 75), Publisher: Acta Biochimica Polonica
    Date:
    conference 13-16.09.2016
    Status:
    Published
    DOI:
    link to the publication

  6. Label-free proteomic analysis of plasma of cystathionine β-synthase deficient mice and humans reveals changes in blood coagulation, hemostasis and antioxidant activity

    Authors:
    Marta Sikora,Izabela Bielińska ,Łukasz Marczak, Hieronim Jakubowski
    Conference:
    11th International Conference on Homocysteine and One Carbon Metabolism, Aarhus , Dania (year: 2017, pages: 85), Publisher: Aarhus University
    Date:
    conference 14-18.05
    Status:
    Published
    DOI:
    link to the publication

  7. Methionine-induced hyperhomocysteinemia causes changes in the mouse kidney proteome associated with blood coagulation

    Authors:
    Izabela Bielińska, Marta Sikora, Hieronim Jakubowski
    Conference:
    12 th Central and Eastern European Proteomic Conference (CEEPC), Bucharest, Romania (year: 2018, pages: 74), Publisher: Central and Eastern European Proteomic Conference
    Date:
    conference 24-26.10
    Status:
    Published
    DOI:
    link to the publication

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