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Transcriptomic analysis of tumor cells treated with the synergistic combination of substences activating p53 protein- searching for unknown regulators of apoptosis.

2014/15/D/NZ5/03410

Keywords

Descriptors

  • NZ5_7: Leczenie chorób człowieka
  • NZ3_1: Biologia komórki
  • NZ5_9: Inne zagadnienia pokrewne

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Agnieszka Gdowicz-Kłosok

Number of co-investigators in the project: 3

Call

SONATA 8 – announced on 2014-09-15

Amount awarded
218 000 PLN
Project start date
2015-08-27
Project end date
2019-08-26
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (3)

  1. Alzheimer's disease-associated TREM2 gene is regulated by p53 tumor suppressor protein

    Authors:
    Artur Zajkowicz*, Agnieszka Gdowicz-Kłosok*, Małgorzata Krześniak, Patryk Janus, Barbara Łasut and Marek Rusin
    Academic press:
    Neuroscience letters (year: 2018, volume: 681, pages: 62-97), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neulet.2018.05.037 – link to the publication

  2. Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity.

    Authors:
    Krześniak M, Zajkowicz A, Gdowicz-Kłosok A, Łasut-Szyszka B, Rusin M.
    Academic press:
    Cellular Signalling (year: 2020, volume: 69:109552, pages: 46038), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cellsig.2020.109552 – link to the publication

  3. PIM2 survival kinase is upregulated in a p53-dependent manner in cells treated with camptothecin or co-treated with actinomycin D and nutlin-3a.

    Authors:
    Artur Zajkowicz, Małgorzata Krześniak, Agnieszka Gdowicz-Kłosok, Barbara Łasut, Marek Rusin
    Academic press:
    Archives of Biochemistry and Biophysics (year: 2018, volume: 655, pages: 26-36), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.abb.2018.08.005 – link to the publication

Articles in post-conference publications (11)

  1. BIAŁKO P53 I INTERFERONY – SPRZYMIERZEŃCY W WALCE Z WIRUSAMI I NOWOTWORAMI.

    Authors:
    Rusin M, Łasut-Szyszka B, Krześniak M, Zajkowicz A, Gdowicz-Kłosok A
    Conference:
    IV Spotkania z Onkologią Molekularną i Translacyjną (year: 2019, pages: 8), Publisher: COI Warszawa
    Date:
    conference 04-05.04.
    Status:
    Published

  2. Strong activation of p53 tumor suppressor protein is assiociated with coordinated upregulation of proteins protecting against infections.

    Authors:
    Rusin M, Łasut-Szyszka B, Gdowicz-Kłosok A, Krześniak M, Zajkowicz A
    Conference:
    13th Central and Eastern European Proteomic Conference (year: 2019, pages: MO-3), Publisher: 13th Central and Eastern European Proteomic Conference
    Date:
    conference 23-26.09.
    Status:
    Published

  3. DUSP13 gene-the novel potential p53 target.

    Authors:
    Małgorzata Krześniak, Agnieszka Gdowicz-Kłosok, Artur Zajkowicz, Iwona Matuszczyk, Marek Rusin
    Conference:
    XXth Gliwice Scientific Meetings 2016 (year: 2016, pages: 85), Publisher: XXth Gliwice Scientific Meetings 2016
    Date:
    conference 18-19.11.
    Status:
    Published

  4. THE SURVIVAL KINASE PIM2 IS EFFICIENTLY STIMULATED BY STRONGLY ACTIVATED P53 PROTEIN

    Authors:
    Małgorzata Krześniak, Artur Zajkowicz, Agnieszka Gdowicz-Kłosok, Barbara Łasut-Szyszka, Marek Rusin
    Conference:
    XXIInd Gliwice Scientific Meetings (year: 2018, pages: 62), Publisher: XXIInd Gliwice Scientific Meetings
    Date:
    conference 16-17.11.
    Status:
    Published

  5. THE p53 TUMOR SUPRESSOR PROTEIN STIMULATES THE EXPRESSION OF BLNK -GENE IMPORTANT IN HUMORAL IMMUNE SYSTEM

    Authors:
    Barbara Łasut-Szyszka, Agnieszka Gdowicz-Kłosok, Małgorzata Krześniak, Artur Zajkowicz, Iwona Matuszczyk, Marek Rusin
    Conference:
    XXIInd Gliwice Scientific Meetings (year: 2018, pages: 74), Publisher: XXIInd Gliwice Scientific Meetings
    Date:
    conference 16-17.11.
    Status:
    Published

  6. Regulation of innate immunity genes by p53 tumor suppressor protein

    Authors:
    M. Rusin, A. Zajkowicz, M. Krześniak, A. Gdowicz-Kłosok
    Conference:
    XXIst Gliwice Scientific Meetings (year: 2017, pages: 40), Publisher: XXIst Gliwice Scientific Meetings
    Date:
    conference 17-18.11.
    Status:
    Published

  7. THE P53 TUMOR SUPPRESSOR PROTEIN STIMULATES THE EXPRESSION OF ALZHEIMER'S DISEASE-ASSOCIATED TREM2 GENE IN CANCER CELLS OF DIFFERENT ORGIN.

    Authors:
    Łasut B, Krześniak M, Zajkowicz A, Gdowicz-Kłosok A, Rusin M.
    Conference:
    XII Copernican International Young Scientists Conference (year: 2018, pages: 63), Publisher: Nicolaus Copernicus University in Torun
    Date:
    conference 28-29.06.
    Status:
    Published

  8. TREM2 gene associated with the risk of Alzheimer's disease is upregulated by p53 tumor suppressor protein in cancer cells of different origin.

    Authors:
    Krześniak M, Zajkowicz A, Gdowicz-Kłosok A, Janus P, Łasut B, Rusin M.
    Conference:
    10th ANNIVERSARY INTERNATIONAL CONFERENCE OF CONTEMPORARY ONCOLOGY (year: 2018, pages: 29), Publisher: współczesna onkologia
    Date:
    conference 21–23.03.
    Status:
    Published

  9. Supresor procesu nowotworowego białko p53, a procesy neurodegeneracyjne

    Authors:
    Łasut B, Gdowicz-Kłosok A, Krześniak M, Zajkowicz A, Rusin M
    Conference:
    Śląskie Spotkania Naukowe (year: 2018, pages: 25), Publisher: Śląskie Spotkania Naukowe
    Date:
    conference 25-26.05.
    Status:
    Published

  10. Hyperactivation of p53 is associated with upregulation of STING, NLRX1, IFIT1 and IFIT3 genes involved in innate immunity

    Authors:
    M. Krześniak, A. Zajkowicz, A. Gdowicz-Kłosok, I. Matuszczyk, M. Rusin
    Conference:
    XXIst Gliwice Scientific Meetings (year: 2017, pages: 107), Publisher: XXIst Gliwice Scientific Meetings
    Date:
    conference 17-18.11
    Status:
    Published

  11. PORÓWNANIE TRANSKTYPTOMÓW KOMÓREK A549 TRAKTOWANYCH INTERFERONEM-Α1 LUB CZYNNIKAMI AKTYWUJĄCYMI BIAŁKO P53.

    Authors:
    Łasut-Szyszka B, Gdowicz-Kłosok A, Krześniak M, Zajkowicz A, Rusin M.
    Conference:
    IV Spotkania z Onkologią Molekularną i Translacyjną (year: 2019, pages: 24), Publisher: COI Warszawa
    Date:
    conference 04-05.04
    Status:
    Published

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