Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Pathophysiological consequences of histone N-homocysteinylation in hyperhomocysteinemia caused by CBS deficiency

2014/15/N/NZ5/01647

Keywords:

homocysteine histones protein modification hyperhomocysteinemia epigenetics gene expresion mouse models

Descriptors:

  • NZ5_3:
  • NZ2_3:
  • NZ1_2:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Izabela Anna Lewandowska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 8 - announced on 2014-09-15

Amount awarded: 146 760 PLN

Project start date (Y-m-d): 2015-08-25

Project end date (Y-m-d): 2019-08-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Articles in post-conference publications (10)
  1. Methionine - induced hyperhomocysteinemia causes changes in the mouse kidney proteome associated with blood coagulation
    Authors:
    Izabela Bielińska, Marta Sikora, Hieronim Jakubowski
    Conference:
    The 12 th Central and Eastern European Proteomic Conference, Bukareszt 2018 (rok: 2018, ), Wydawca: Central and Eastern European Proteomic Conference
    Data:
    konferencja 24-26.10.2018
    Status:
    Published
    DOI:
    link to the publication
  2. Methionine-induced hyperhomocysteinemia causes changes in the mouse kidney proteome associated with blood coagulation
    Authors:
    Izabela Bielińska, Marta Sikora, Hieronim Jakubowski
    Conference:
    3rd Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2018 Gdańsk 2018 , Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 18-21.09.2018
    Status:
    Published
    DOI:
    link to the publication
  3. Label - free proteomic analysis of plasma of cystathionine β - synthase deficient mice and humans reveals changes in blood coagulation, hemostasis and a ntioxidant activity
    Authors:
    Marta Sikora, Izabela Bielińska, Hieronim Jakubowski
    Conference:
    11th International Conference on Homocysteine & One-Carbon Metabolism, Aarhus 2017 (), Wydawca: Aarhus University
    Data:
    konferencja 14-18.05.2017
    Status:
    Published
    DOI:
    link to the publication
  4. Methionine - induced hyperhomocysteinemia causes changes in the mouse kidney proteome associated with blood coagulation
    Authors:
    Izabela Bielińska, Marta Sikora, Hieronim Jakubowski
    Conference:
    The 12 th Central and Eastern European Proteomic Conference, Bukareszt 2018 , Wydawca: Central and Eastern European Proteomic Conference
    Data:
    konferencja 24-26.10.2018
    Status:
    Published
    DOI:
    link to the publication
  5. Label - free proteomic analysis of plasma of cystathionine β - synthase deficient mice and humans reveals changes in blood coagulation, hemostasis and a ntioxidant activity
    Authors:
    Marta Sikora, Izabela Bielińska, Hieronim Jakubowski
    Conference:
    11th International Conference on Homocysteine & One-Carbon Metabolism, Aarhus 2017 (rok: 2017, ), Wydawca: Aarhus University
    Data:
    konferencja 14-18.05.2017
    Status:
    Published
    DOI:
    link to the publication
  6. Label-free proteomic analysis reveals changes in blood coagulation and red-ox homeostasis in the heart of cystathionine β-synthase deficient mice
    Authors:
    Izabela Lewandowska, Marta Sikora, Hieronim Jakubowski
    Conference:
    44th FEBS Congress, Kraków 2019 (rok: 2019, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 6-11.07.2019
    Status:
    Published
    DOI:
    link to the publication
  7. Label-free proteomic analysis reveals changes in red-ox and lipid homeostasis in the liver of cystathionine β-synthase deficient mice
    Authors:
    Izabela Bielińska, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    2nd Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2016 Wrocław 2016 (rok: 2016, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 13-16.09.2016
    Status:
    Published
    DOI:
    link to the publication
  8. Cystathionine ß - synthase deficiency induces changes in the mouse brain proteome associated with neurodegenerative disease
    Authors:
    Izabela Bielińska, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    11th International Conference on Homocysteine & One-Carbon Metabolism, Aarhus 2017 (), Wydawca: Aarhus University
    Data:
    konferencja 14-18.05.2017
    Status:
    Published
    DOI:
    link to the publication
  9. Cystathionine ß - synthase deficiency induces changes in the mouse brain proteome associated with neurodegenerative disease
    Authors:
    Izabela Bielińska, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    11th International Conference on Homocysteine & One-Carbon Metabolism, Aarhus 2017 (rok: 2017, ), Wydawca: Aarhus University
    Data:
    konferencja 14-18.05.2017
    Status:
    Published
    DOI:
    link to the publication
  10. Methionine-induced hyperhomocysteinemia causes changes in the mouse kidney proteome associated with blood coagulation
    Authors:
    Izabela Bielińska, Marta Sikora, Hieronim Jakubowski
    Conference:
    3rd Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2018 Gdańsk 2018 (rok: 2018, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 18-21.09.2018
    Status:
    Published
    DOI:
    link to the publication

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