Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Pathophysiological consequences of histone N-homocysteinylation in hyperhomocysteinemia caused by CBS deficiency

2014/15/N/NZ5/01647

Keywords:

homocysteine histones protein modification hyperhomocysteinemia epigenetics gene expresion mouse models

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ2_3: Proteomics
  • NZ1_2: Biochemistry

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Izabela Lewandowska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 8 - announced on 2014-09-15

Amount awarded: 146 760 PLN

Project start date (Y-m-d): 2015-08-25

Project end date (Y-m-d): 2019-08-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (6)
  1. Cystathionine β‑synthase defciency: diferent changes in proteomes of thrombosis‑resistant Cbs−/− mice and thrombosis‑prone CBS−/− humans
    Authors:
    Marta Sikora, Izabela Lewandowska, Łukasz Marczak, Ewa Bretes, Hieronim Jakubowski
    Academic press:
    Scientific Reports (rok: 2020, tom: 10(10726), strony: 45303), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-020-67672-5 - link to the publication
  2. Serum Proteome Alterations in Human Cystathionine β-Synthase Deficiency and Ischemic Stroke Subtypes
    Authors:
    Marta Sikora, Izabela Lewandowska, Małgorzata Kupc, Jolanta Kubalska, Ałła Graban, Łukasz Marczak,1 Radosław Kaźmierski, Hieronim Jakubowski
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(12), strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20123096 - link to the publication
  1. Cystathionine ß - synthase deficiency induces changes in the mouse brain proteome associated with neurodegenerative disease
    Authors:
    Izabela Bielińska, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    11th International Conference on Homocysteine & One-Carbon Metabolism, Aarhus 2017 (rok: 2017, ), Wydawca: Aarhus University
    Data:
    konferencja 14-18.05.2017
    Status:
    Published
    DOI:
    link to the publication
  2. Label - free proteomic analysis of plasma of cystathionine β - synthase deficient mice and humans reveals changes in blood coagulation, hemostasis and a ntioxidant activity
    Authors:
    Marta Sikora, Izabela Bielińska, Hieronim Jakubowski
    Conference:
    11th International Conference on Homocysteine & One-Carbon Metabolism, Aarhus 2017 (rok: 2017, ), Wydawca: Aarhus University
    Data:
    konferencja 14-18.05.2017
    Status:
    Published
    DOI:
    link to the publication
  3. Methionine - induced hyperhomocysteinemia causes changes in the mouse kidney proteome associated with blood coagulation
    Authors:
    Izabela Bielińska, Marta Sikora, Hieronim Jakubowski
    Conference:
    The 12 th Central and Eastern European Proteomic Conference, Bukareszt 2018 (rok: 2018, ), Wydawca: Central and Eastern European Proteomic Conference
    Data:
    konferencja 24-26.10.2018
    Status:
    Published
    DOI:
    link to the publication
  4. Methionine-induced hyperhomocysteinemia causes changes in the mouse kidney proteome associated with blood coagulation
    Authors:
    Izabela Bielińska, Marta Sikora, Hieronim Jakubowski
    Conference:
    3rd Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2018" Gdańsk 2018 (rok: 2018, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 18-21.09.2018
    Status:
    Published
    DOI:
    link to the publication
  5. Label-free proteomic analysis reveals changes in blood coagulation and red-ox homeostasis in the heart of cystathionine β-synthase deficient mice
    Authors:
    Izabela Lewandowska, Marta Sikora, Hieronim Jakubowski
    Conference:
    44th FEBS Congress, Kraków 2019 (rok: 2019, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 6-11.07.2019
    Status:
    Published
    DOI:
    link to the publication
  6. Label-free proteomic analysis reveals changes in red-ox and lipid homeostasis in the liver of cystathionine β-synthase deficient mice
    Authors:
    Izabela Bielińska, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    2nd Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2016" Wrocław 2016 (rok: 2016, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 13-16.09.2016
    Status:
    Published
    DOI:
    link to the publication

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