Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Cellular and molecular mechanisms in pathology of post-inflammatory myocardial fibrosis

2014/14/E/NZ5/00175

Keywords:

myocarditis myocardial fibrosis myofibroblasts heart failure

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Przemysław Błyszczuk 

Number of co-investigators in the project: 5

Call: SONATA BIS 4 - announced on 2014-06-16

Amount awarded: 1 999 693 PLN

Project start date (Y-m-d): 2015-08-12

Project end date (Y-m-d): 2021-08-11

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw komputerowy wraz z oprogramowaniem (3 szt.) (18 000 PLN)
  2. Drukarka laserowa (1 500 PLN)
  3. Ultrawirówka do 100 000 g (250 000 PLN)
  4. Inkubator do hodowli komórkowych (39 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (1)
  1. Crosstalk between the TGF-β and WNT signalling pathways during cardiac fibrogenesis
    Authors:
    Edyta Działo, Karolina Tkacz, Przemysław Błyszczuk
    Academic press:
    Acta Biochimica Polonica (rok: 2018, tom: Vol 65 No 3, strony: 341-349), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published
    DOI:
    10.18388/abp.2018_2635 - link to the publication
  2. WNT3a and WNT5a Transported by Exosomes Activate WNT Signaling Pathways in Human Cardiac Fibroblasts
    Authors:
    Dzialo E, Rudnik M, Koning RI, Czepiel M, Tkacz K, Baj-Krzyworzeka M, Distler O, Siedlar M, Kania G, Blyszczuk P.
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: 45306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20061436 - link to the publication
  3. Angiotensin II receptor 1 controls profibrotic Wnt/β-catenin signalling in experimental autoimmune myocarditis
    Authors:
    Czepiel M, Diviani D, Jaźwa-Kusior A , Tkacz K, Rolski F, Smolenski RT, Siedlar M, Eriksson U, Kania G , Błyszczuk P
    Academic press:
    Cardiovascular Research (rok: 2022, tom: 118(2), strony: 573-584), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/cvr/cvab039 - link to the publication
  4. Haploinsufficient Rock1+/- and Rock2+/- Mice Are Not Protected from Cardiac Inflammation and Postinflammatory Fibrosis in Experimental Autoimmune Myocarditis
    Authors:
    Tkacz K, Rolski F, Czepiel M, Działo E, Siedlar M, Eriksson U, Kania G, Błyszczuk P
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 45307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9030700 - link to the publication
  5. Myocarditis in Humans and in Experimental Animal Models
    Authors:
    Przemysław Błyszczuk
    Academic press:
    Frontiers in Cardiovascular Medicine (rok: 2019, tom: 6, strony: 45308), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcvm.2019.00064 - link to the publication
  6. WNT/β-catenin signaling promotes TGF-β-mediated activation of human cardiac fibroblasts by enhancing IL-11 production
    Authors:
    Działo E, Czepiel M, Tkacz K, Siedlar M, Kania G, Błyszczuk P
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(18), strony: 45307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms221810072 - link to the publication
  1. Role of angiotensin II receptor type 1 in TGF-beta-mediated fibrogenesis in mouse model of experimental autoimmune myocarditis
    Authors:
    M. Czepiel G. Kania D. Diviani O. Diestler U. Eriksson M. Siedlar P. Blyszczuk
    Conference:
    ESC Congress 2017 (rok: 2017, ), Wydawca: European Heart Journal
    Data:
    konferencja 26-30 August
    Status:
    Published
    DOI:
    link to the publication

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