Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Analysis of relations on the level of metabolome, miRNome, and transcriptome of human renal cancer: towards identification of regulators of cellular metabolism as potential therapeutic targets and cancer markers.

2014/13/B/NZ5/00283

Keywords:

metabolome microRNA Warburg effect pentose phosphate pathway TCA cycle proliferation renal cancer

Descriptors:

  • NZ2_4: Metabolomics
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ5_1: Etiology of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Centrum Medyczne Kształcenia Podyplomowego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Piekiełko-Witkowska 

Number of co-investigators in the project: 5

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 1 335 958 PLN

Project start date (Y-m-d): 2015-02-18

Project end date (Y-m-d): 2018-02-17

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komora laminarna do PCR (23 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (4)
  1. Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system
    Authors:
    Popławski P, Wiśniewski JR, Rijntjes E, Richards K, Rybicka B, Köhrle J, Piekiełko-Witkowska A.
    Academic press:
    Plos One (rok: 2017, tom: 12, strony: 45317), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal. - link to the publication
  2. Integrated transcriptomic and metabolomic analysis shows that disturbances in metabolism of tumor cells contribute to poor survival of RCC patients.
    Authors:
    Popławski P, Tohge T, Bogusławska J, Rybicka B, Tański Z, Treviño V, Fernie AR, Piekiełko-Witkowska A
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (rok: 2017, tom: 1863(3), strony: 744-752), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2016.12.011 - link to the publication
  3. MicroRNA-Mediated Metabolic Reprograming in Renal Cancer
    Authors:
    Bogusławska J, Popławski P, Alseekh S, Koblowska M, Iwanicka-Nowicka R, Rybicka B, Kędzierska H, Głuchowska K, Hanusek K, Tański Z, Fernie AR, Piekiełko-Witkowska A.
    Academic press:
    Cancers (rok: 2019, tom: 11(12), strony: 45312), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11121825 - link to the publication
  4. The signifcance of TRIP11 and T3 signalling pathway in renal cancer progression and survival of patients
    Authors:
    Piotr Popławski, Agnieszka Piekiełko-Witkowska, Alicja Nauman
    Academic press:
    Endokrynologia Polska (rok: 2017, tom: 68, strony: 631-641), Wydawca: Via Medica Journals
    Status:
    Published
    DOI:
    10.5603/EP.a2017.0052 - link to the publication
  5. Decreased Expression of SRSF2 Splicing Factor Inhibits Apoptotic Pathways in Renal Cancer.
    Authors:
    Kędzierska H, Popławski P, Hoser G, Rybicka B, Rodzik K, Sokół E, Bogusławska J, Tański Z, Fogtman A, Koblowska M, Piekiełko-Witkowska A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2016, tom: 17(10), strony: pii: E1598), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/ijms17101598 - link to the publication
  1. A network of microRNAs potentially regulating metabolic pathways in renal cancer
    Authors:
    J. Boguslawska, P. Poplawski, B. Rybicka, K. Rodzik, H. Kedzierska, A. Piekielko-Witkowska
    Conference:
    EACR-AACR-SIC SPECIAL CONFERENCE 2017; The Challenges of Optimising Immuno and Targeted Therapies; From Cancer Biology to the Clinic (rok: 2017, ), Wydawca: EACR-AACR-SIC
    Data:
    konferencja 24-27.06.2017
    Status:
    Published
  2. Combined transcriptomic and metabolomic analysis reveals link betweenbeta-alanine metabolism pathway and progression of renal cancer
    Authors:
    Piotr Popławski, Takayuki Tohge, Beata Rybicka, Joanna Bogusławska, Zbigniew Tański, Alisdair R. Fernie, Agnieszka Piekiełko-Witkowska
    Conference:
    2nd Congress of Polish Biochemistry, Cell biology, Biotechnology and Bioinformatics Bio2016 – Expanding beyond the limits" (rok: 2016, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 13-16.09.2016
    Status:
    Published
  3. MicroRNAs dependent regulation of proliferation properties in renal cancer cells
    Authors:
    Katarzyna Rodzik, Joanna Bogusławska, Piotr Popławski, Agnieszka Piekiełko-Witkowska
    Conference:
    V Międzyuczelniane Sympozjum Biotechnologiczne "Symbioza" (rok: 2016, ), Wydawca: V Międzyuczelniane Sympozjum Biotechnologiczne "Symbioza"
    Data:
    konferencja 22-24.04.2016
    Status:
    Published
  4. PROTEOMIC ANALYSIS REVEALS METABOLIC PATHWAYS AFFECTED BY DECREASED EXPRESSION OF TYPE 1 IODOTHYRONINE DEIODINASE IN RENAL CANCER
    Authors:
    Piotr Popawski, Jacek R. Wiœniewski, Beata Rybicka, Agnieszka Piekielko-Witkowska
    Conference:
    40th Annual Meeting of the European Thyroid Association (rok: 2017, ), Wydawca: Karger
    Data:
    konferencja 2017.09.09-12
    Status:
    Published

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