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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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RNA hybrid duplex-quadruplex structures with dual functionality as a new tool for silecing of gene expression

2014/13/B/ST5/04144

Keywords:

RNA quadruplexes modified oligonucleotides NMR CD and UV spectroscopy silencing of gene expression

Descriptors:

  • ST5_1: Structural properties of materials
  • ST5_16:
  • ST5_20:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Zofia Gdaniec 

Number of co-investigators in the project: 6

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 891 000 PLN

Project start date (Y-m-d): 2015-01-23

Project end date (Y-m-d): 2018-07-22

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw komputerowy (6 000 PLN)
  2. Olejowa pompa próżniowa (11 000 PLN)
  3. Spektrofotometr dwuwiązkowy UV-Vis z detektorem opartym o fotopowielacz z zestawem kuwet (140 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs
    Authors:
    SM. Lyons, D. Gudanis, SM. Coyne, Z. Gdaniec, P. Ivanov
    Academic press:
    Nature Communications (rok: 2017, tom: 8, strony: 1127), Wydawca: NATURE PUBLISHING GROUP
    Status:
    Published
    DOI:
    10.1038/s41467-017-01278-w - link to the publication
  2. Overview of the RNA G-quadruplex structures
    Authors:
    M. Małgowska, K. Czajczyńska, D. Gudanis, A. Tworak, Z. Gdaniec
    Academic press:
    Acta Biochimica Polonica (rok: 2016, tom: 63, strony: 609-621), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/abp.2016_1335 - link to the publication
  3. Thermodynamic Features of Structural Motifs Formed by β-L-RNA
    Authors:
    M. Szabat, D. Gudanis, W. Kotkowiak, Z.Gdaniec, R.Kierzek, A. Pasternak
    Academic press:
    PLOS ONE (rok: 2016, tom: 11(2), strony: e0149478), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0149478 - link to the publication
  4. Structural characterization of a dimer of RNA duplexes composed of 8-bromoguanosine modified CGG trinucleotide repeats: a novel architecture of RNA quadruplexes
    Authors:
    D. Gudanis, L. Popenda K. Szpotkowski, R. Kierzek, Z. Gdaniec
    Academic press:
    Nucleic Acids Research (rok: 2016, tom: 44, strony: 2409-2416), Wydawca: Oxford Univ Press
    Status:
    Published
    DOI:
    10.1093/nar/gkv1534 - link to the publication
  5. Unraveling the structural basis for the exceptional stability of RNA G-quadruplexes capped by a uridine tetrad at the 3' terminus
    Authors:
    W. Andrałojć, M. Małgowska, J. Sarzyńska, K. Pasternak, K. Szpotkowski, R. Kierzek, Z. Gdaniec
    Academic press:
    RNA (rok: 2019, tom: 25, strony: 121-134), Wydawca: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna.068163.118 - link to the publication

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