Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Mechanism of SYK-mediated suppression of differentiation and apoptosis in acute myeloid leukemia (AML)

2013/11/N/NZ5/03704

Keywords:

signal transduction AML AKT ERK1/2 differentiation arrest

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Hematologii i Transfuzjologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Polak 

Number of co-investigators in the project: 2

Call: PRELUDIUM 6 - announced on 2013-09-16

Amount awarded: 149 539 PLN

Project start date (Y-m-d): 2014-09-03

Project end date (Y-m-d): 2017-09-02

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (2)
  1. SYK inhibition targets acute myeloid leukemia stem cells by blocking their oxidative metabolism
    Authors:
    Anna Polak, Emilia Bialopiotrowicz, Beata Krzymieniewska, Jolanta Wozniak, Marta Stojak, Magdalena Cybulska, Ewelina Kaniuga, Michał Mikula, Ewa Jablonska, Patryk Gorniak, Monika Noyszewska-Kania, Maciej Szydlowski, Karolina Piechna, Katarzyna Piwocka, Lukasz Bugajski, Ewa Lech-Maranda, Joanna Barankiewicz, Agnieszka Kolkowska-Lesniak, Elzbieta Patkowska, Eliza Glodkowska-Mrowka, Natalia Baran, Przemyslaw Juszczynski
    Academic press:
    Cell Death and Disease (rok: 2020, tom: 11, strony: article number 956), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41419-020-03156-8 - link to the publication
  1. ZAHAMOWANIE AKTYWNOŚCI KINAZY SYK W KOMÓRKACH LSC OSTREJ BIAŁACZKI SZPIKOWEJ (AML) PROWADZI DO OBNIŻENIA KLONOGENNOŚCI ORAZ INDUKCJI RÓŻNICOWANIA I APOPTOZY
    Authors:
    dr Anna Polak, dr Przemysław Kiliszek, dr Tomasz Sewastianik, dr Maciej Szydłowski, dr Ewa Jabłońska, dr Emilia Białopiotrowicz, dr Patryk Górniak, Monika Noyszewska-Kania, Krolina Piechna, Jolanta Woźniak, Beata Krzymieniewska, Elżbieta Patkowska, Agnieszka Kołkowska-Leśniak, prof. Ewa Lech-Marańda, prof. Krzysztof Warzocha, prof. Przemysław Juszczyński
    Conference:
    XXVII Zjazd Polskiego Towarzystwa Hematologów i Transfuzjologów (rok: 2017, ), Wydawca: PTHIT
    Data:
    konferencja 21.09-23.09
    Status:
    Published
  2. MECHANISMS OF SYK-MEDIATED SUPPRESSION OF DIFFERENTIATION AND APOPTOSIS IN ACUTE MYELOID LEUKEMIA (AML)
    Authors:
    Anna Polak , Przemyslaw Kiliszek , Tomasz Sewastianik , Maciej Szydlowski , Ewa Jablonska , Emilia Bialopiotrowicz , Patryk Gorniak , Monika Noyszewska-Kania , Karolina Piechna , Jolanta Wozniak , Beata Krzymieniewska , Ewa Lech-Maranda , Krzysztof Warzocha , Przemyslaw Juszczynski
    Conference:
    22nd Congress of EHA (rok: 2017, ), Wydawca: EHA Learning Center
    Data:
    konferencja 22.06-25.06
    Status:
    Published