Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Genetics of pediatric T-cell acute lymphoblastic leukemia

2013/11/N/NZ5/03730

Keywords:

leukemia leukemogenesis mutations T-lymphocytes

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_9: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Genetyki Człowieka PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Bronisława Szarzyńska-Zawadzka 

Number of co-investigators in the project: 3

Call: PRELUDIUM 6 - announced on 2013-09-16

Amount awarded: 145 415 PLN

Project start date (Y-m-d): 2014-08-27

Project end date (Y-m-d): 2017-08-26

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Laptop z oprogramowaniem (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Association of germline genetic variants in RFC, IL15 and VDR genes with minimal residual disease in pediatric B-cell precursor ALL.
    Authors:
    Dawidowska M, Kosmalska M, Sędek Ł, Szczepankiewicz A, Twardoch M, Sonsala A, Szarzyńska-Zawadzka B, Derwich K, Lejman M, Pawelec K, Obitko-Płudowska A, Pawińska-Wąsikowska K, Kwiecińska K, Kołtan A, Dyla A, Kowalczyk JR, Szczepański T, Ziętkiewicz E, Witt M.
    Academic press:
    Scientific Reports (rok: 2016, tom: 6:29427, strony: nie dotyczy), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/srep29427 - link to the publication
  2. Translocation t(8;14)(q24;q11) with concurrent PTEN alterations and deletions of STIL/TAL1 and CDKN2A/B in a pediatric case of acute T-lymphoblastic leukemia: A genetic profile associated with adverse prognosis.
    Authors:
    Skalska-Sadowska J, Dawidowska M, Szarzyńska-Zawadzka B, Jarmuż-Szymczak M, Czerwińska-Rybak J, Machowska L, Derwich K.
    Academic press:
    Pediatric Blood Cancer (rok: 2017, tom: 64, strony: e26266), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/pbc.26266 - link to the publication
  3. Cost-effective screening of DNMT3A coding sequence identifies somatic mutation in pediatric T-cell acute lymphoblastic leukemia.
    Authors:
    Szarzyńska-Zawadzka B, Kosmalska M, Sędek Ł, Sonsala A, Twardoch M, Kowalczyk JR, Szczepański T, Witt M, Dawidowska M.
    Academic press:
    European Journal of Haematology (rok: 2017, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/ejh.12964. - link to the publication
  4. PTEN abnormalities predict poor outcome in children with T‐cell acute lymphoblastic leukemia treated according to ALL IC‐BFM protocols
    Authors:
    Bronisława Szarzyńska‐Zawadzka, Joachim B. Kunz, Łukasz Sędek, Maria Kosmalska, Katarzyna Zdon, Przemysław Biecek, Obul R. Bandapalli, Monika Kraszewska‐Hamilton, Roman Jaksik, Monika Drobna, Jerzy R. Kowalczyk, Tomasz Szczepański, Pieter Van Vlierberghe, Andreas E. Kulozik, Michał Witt, Małgorzata Dawidowska
    Academic press:
    American Journal of Hematology (rok: 2019, tom: 4, strony: E93-E96), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ajh.25396 - link to the publication

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