A comparative evaluation of effectiveness of phosphorothioate and phosphodiester lysophosphatidylcholine analogues in regulation of diabetes mellitus-related processes - in vitro studies of glucose uptake modulation and new receptors activity.
2013/11/N/NZ5/00270
Keywords
Descriptors
- NZ5_7: Leczenie chorób człowieka
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- NZ3_7: Przekaźnictwo sygnału
Panel
NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution
Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności
Voivodeship: łódzkie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 6 – announced on 2013-09-16
- Amount awarded
- 99 580 PLN
- Project start date
- 2014-08-04
- Project end date
- 2017-02-03
- Project duration
- 30 months (the same as in the proposal)
- Project status
- Project settled
Information in the final report
Publication in academic press/journals (5)
-
Sulfur- and Acyl Chain-Dependent Influence of 2-Methoxy-Lysophosphatidylcholine Analogues on beta Pancreatic Cells
- Authors:
- Drzazga, Anna; Ciesielska, Anna; Gendaszewska-Darmach, Edyta
- Academic press:
- CURRENT TOPICS IN MEDICINAL CHEMISTRY (year: 2015, volume: 15(23), pages: 2395-2405), Publisher: Publisher BENTHAM SCIENCE PUBL LTD
- Status:
- Published
- DOI:
- 10.2174/1568026615666150619141239 – link to the publication
-
Lysophosphatidylcholine and lysophosphatidylinosiol--novel promissing signaling molecules and their possible therapeutic activity.
- Authors:
- Drzazga, Anna; Sowinska, Agata; Koziolkiewicz, Maria
- Academic press:
- Acta poloniae pharmaceutica - drug research (year: 2014, volume: 71(6), pages: 887-99), Publisher: Polskie Towarzystwo Farmaceutyczne
- Status:
- Published
- DOI:
- link to the publication
-
Lysophosphatidylcholine elicits intracellular calcium signaling in a GPR55-dependent manner
- Authors:
- Drzazga A, Sowinska A, Krzeminska A, Rytczak P, Koziolkiewicz M, Gendaszewska-Darmach E
- Academic press:
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (year: 2017, volume: 489(2), pages: 242-247), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.bbrc.2017.05.145. – link to the publication
-
2-OMe-lysophosphatidylcholine analogues are GPR119 ligands and activate insulin secretion from βTC-3 pancreatic cells: evaluation of structure-dependent biological activity
- Authors:
- Drzazga, Anna; Sowińska, Agata; Krzemińska, Agnieszka; Okruszek, Andrzej; Paneth, Piotr; Koziołkiewicz, Maria; Gendaszewska-Darmach, Edyta
- Academic press:
- BBA Molecular and Cell Biology of Lipids (year: 2018, volume: 1863(1), pages: 91-103), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.bbalip.2017.10.004. – link to the publication
-
Lysophosphatidylcholine and its phosphorothioate analogues potentiate insulin secretion via GPR40 (FFAR1), GPR55 and GPR119 receptors in a different manner
- Authors:
- Drzazga A, Kristinsson H, Sałaga M, Zatorski H, Koziołkiewicz M, Gendaszewska-Darmach E, Bergsten P
- Academic press:
- MOLECULAR AND CELLULAR ENDOCRINOLOGY (year: 2017, volume: S0303-7207(17), pages: 46031), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.mce.2017.12.002 – link to the publication